1-naphthyl 3,5-dinitrobenzoate
- Product Name
- 1-naphthyl 3,5-dinitrobenzoate
- CAS No.
- 93261-39-3
- Chemical Name
- 1-naphthyl 3,5-dinitrobenzoate
- Synonyms
- JMC-4;1-naphthyl 3,5-dinitrobenzoate;napthalen-1-yl 3,5-dinitrobenzoate;naphthalen-1-yl 3,5-dinitrobenzoate;1-(3,5-DINITROBENZOATE) 1-NAPHTHALENOL;1-Naphthalenol, 1-(3,5-dinitrobenzoate);1-Naphthyl 3,5-dinitrobenzoate, 10 mM in DMSO;1Naphthyl 3,5dinitrobenzoate,1 Naphthyl 3,5 dinitrobenzoate
- CBNumber
- CB41957790
- Molecular Formula
- C17H10N2O6
- Formula Weight
- 338.27
- MOL File
- 93261-39-3.mol
1-naphthyl 3,5-dinitrobenzoate Property
- Melting point:
- 217-219 °C(Solv: toluene (108-88-3))
- Boiling point:
- 541.4±40.0 °C(Predicted)
- Density
- 1.466±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤0.1mg/ml in methanol;0.5mg/ml in DMSO
- form
- crystalline solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 11729
- Product name
- 1-Naphthyl 3,5-dinitrobenzoate
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2026/04/30
- Product number
- 11729
- Product name
- 1-Naphthyl 3,5-dinitrobenzoate
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $153
- Updated
- 2026/04/30
- Product number
- 11729
- Product name
- 1-Naphthyl 3,5-dinitrobenzoate
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $268
- Updated
- 2026/04/30
- Product number
- 11729
- Product name
- 1-Naphthyl 3,5-dinitrobenzoate
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $587
- Updated
- 2026/04/30
- Product number
- 11729
- Product name
- 1-Naphthyl 3,5-dinitrobenzoate
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
1-naphthyl 3,5-dinitrobenzoate Chemical Properties,Usage,Production
Uses
1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 μM and 3.6 μM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation[1].
Biological Activity
1-naphthyl 3,5-dinitrobenzoate is a dual 5-lipoxygenase and microsomal prostaglandin e synthase-1 inhibitor.human 5-lipoxygenase (5-lox), a target for antiinflammation drug design, catalyzes the first two reactions in the production of leukotrienes from arachidonic acid (aa): oxygenation of aa to 5-hpete and further dehydration to leukotriene a4 (lta4). then lta4 is metabolized to other leukotrienes. furthermore, 5-lox is also found to play key roles in tumor formation and cancer metastasis and thus is considered as a potential target for anticancer drugs.
in vitro
a previous study built a comparative model for the human 5-lox closed conformation and successfully used it in virtual screening. out of around 200 000 compounds, 105 compounds were selected for experimental test. in cell-free assay, 30 compounds were found to have ic50 values less than 100 μm and 11 with ic50 values less than 10 μm. eventually, 1-naphthyl 3,5-dinitrobenzoate was screened out to have inhibition activity in the human whole blood assay with ic50 values less than 10 μm. 1-naphthyl 3,5-dinitrobenzoate was also identified as efficient dualfunctional inhibitors of 5-lox and mpges-1 in both cell-free assay and cell-based assay. in addition, 1-naphthyl 3,5-dinitrobenzoate was able to simultaneously suppress the production of ltb4 and pge2 in human whole blood, and its targets was verified as 5-lox and mpges-1, not lta4h, cox-1, cox-2 [1].
IC 50
1 and 3.6 μm for 5-lipoxygenase and microsomal prostaglandin e synthase-1, respectively
References
[1] wu, y. ,he, c.,gao, y., et al. dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. journal of medicinal chemistry 55, 2597-2605 (2012).
1-naphthyl 3,5-dinitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
1-naphthyl 3,5-dinitrobenzoate Suppliers
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3505
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 89689
- Advantage
- 60
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24960
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29995
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12000
- Advantage
- 58