ChemicalBook > CAS DataBase List > 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE

Product Name: 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE
CAS No.: 54346-87-1
Chemical Name: 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE
Synonyms: 5-Methoxy-2-benzothiazolamine;5-methoxybenzothiazol-2-amine;2-Amino-5-methoxybenzothiazole;2-Benzothiazolamine, 5-methoxy-;5-METHOXY-BENZOTHIAZOL-2-YLAMINE;5-methoxybenzo[d]thiazol-2-amine;5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE;5-Methoxy-1,3-benzothiazole-2-amine;2-Benzothiazolamine,5-methoxy-(9CI);2-Amino-5-methoxy-1,3-benzothiazole 97%
CBNumber: CB4197250
Molecular Formula: C8H8N2OS
Formula Weight: 180.23
MOL File: 54346-87-1.mol

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5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Property

Melting point:: 154 °C
Boiling point:: 347.5±34.0 °C(Predicted)
Density: 1.359±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 4.53±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 29342000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: B485923
Product name: 5-methoxy-1,3-benzothiazol-2-amine
Packaging: 500mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-1-N7
Product name: 2-Amino-5-methoxy-1,3-benzothiazole
Packaging: 250mg
Price: $24
Updated: 2021/12/16

Matrix Scientific

Product number: 011563
Product name: 5-Methoxy-1,3-benzothiazol-2-amine
Purity: 98%
Packaging: 1g
Price: $69
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0033660
Product name: 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE
Purity: 95.00%
Packaging: 1G
Price: $642.99
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0033660
Product name: 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE
Purity: 95.00%
Packaging: 5G
Price: $1005.43
Updated: 2021/12/16

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5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Chemical Properties,Usage,Production

Synthesis

37014-08-7

54346-87-1

1. Preparation of 5-methoxy-benzothiazol-2-ylamine: To a suspension of (3-methoxyphenyl)thiourea (1.822 g, 10 mmol) in dichloromethane (20 mL) was slowly added dropwise a solution of bromine (1.76 g, 11 mmol) in 10 mL of trichloromethane at 0 °C for 30 min. The reaction mixture was stirred at room temperature for 3 hours and then heated to reflux for 1 hour. After completion of the reaction, the precipitate was collected by filtration and washed with dichloromethane. The solid was suspended in saturated sodium bicarbonate solution and extracted with dichloromethane. The organic phases were combined, dried with magnesium sulfate and concentrated to give a white solid product (1.716 g, 95% yield). 2. Preparation of 2-amino-benzothiazol-5-ol: 5-methoxy-benzothiazol-2-ylamine (1.716g) obtained in the previous step was suspended in 16mL of 48% aqueous hydrobromic acid, and the reaction was heated in an oil bath at 105°C for 10 hours. After the reaction was cooled to room temperature, the precipitate was collected by filtration and washed with acetone. The solid in the filtrate was suspended in saturated sodium bicarbonate solution and extracted with dichloromethane. The organic phase was dried with magnesium sulfate and concentrated to give a white solid product (0.986 g, 63% yield). 3. Synthesis of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[6-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea hydrochloride [Compound B12]: 2-amino-benzothiazol-5-ol obtained from the previous step was used as a raw material, and the reaction was carried out according to the literature method. The product was characterized by nuclear magnetic resonance hydrogen spectroscopy (DMSO-d6) and liquid chromatography-mass spectrometry (LC-MS): 1H NMR (DMSO-d6) δ 11.1 (br, 1H), 9.69 (br, 1H), 9.28 (br, 1H), 8.71 (s, 1H), 7.97 (d, 1H), 7.79 (d and s, 3H), 7.56 (d, 2H), 7.56 (d, 2H), 7.13 (d, 2H). 2H), 7.13 (dd, 1H), 6.53 (s, 1H), 4.56 (t, 2H), 3.98 (m, 2H), 3.82 (t, 2H), 3.65 (m, 2H), 3.55 (m, 2H), 3.25 (m, 2H), 1.31 (s, 9H); LC-MS: ESI 561 (M + H)+.

References

[1] Patent: US2007/232604, 2007, A1. Location in patent: Page/Page column 40
[2] Medicinal Chemistry Research, 2012, vol. 21, # 7, p. 1136 - 1148
[3] Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1956, vol. 22, p. 363,365
[4] Chem.Abstr., 1957, p. 4358
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 21, p. 9814 - 9824

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE Suppliers

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View Lastest Price from 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE manufacturers

Honest Joy Holdings Limited

Product: 5-Methoxybenzo[d]thiazol-2-amine 54346-87-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.3%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE 54346-87-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2018-08-15

54346-87-1, 5-METHOXY-1,3-BENZOTHIAZOL-2-AMINERelated Search:

5-METHOXY-BENZOTHIAZOL-2-YLAMINE

5-methoxybenzothiazol-2-amine

2-Benzothiazolamine,5-methoxy-(9CI)

5-METHOXY-1,3-BENZOTHIAZOL-2-AMINE

5-methoxybenzo[d]thiazol-2-amine

5-Methoxy-2-benzothiazolamine

2-Amino-5-methoxybenzothiazole

5-Methoxy-1,3-benzothiazole-2-amine

2-Amino-5-methoxy-1,3-benzothiazole 97%

2-Benzothiazolamine, 5-methoxy-

54346-87-1

Thiazoles, Isothiazoles & Benzothiazoles

Amines

Thiazoles, Isothiazoles &Benzothiazoles

BENZOTHIAZOLE