5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide
- Product Name
- 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide
- CAS No.
- 868273-06-7
- Chemical Name
- 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide
- Synonyms
- CS-412;Org 27569;ORG 27569;ORG-27569;Org27569 Cannabinoid CB1 receptor allosteric modulator Org-27569;Org27569,Inhibitor,Org-27569,Cannabinoid Receptor,Org 27569,inhibit;N-(4-(piperidin-1-yl)phenethyl)-5-chloro-3-ethyl-1H-indole-2-carboxamide;5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide;5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide;1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]-;Org27569 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H -indole-2-carboxamide
- CBNumber
- CB42092872
- Molecular Formula
- C24H28ClN3O
- Formula Weight
- 409.95
- MOL File
- 868273-06-7.mol
5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Property
- Boiling point:
- 660.3±55.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: <2mg/mL
- pka
- 14.87±0.30(Predicted)
- form
- powder
- color
- white
N-Bromosuccinimide Price
- Product number
- 2957
- Product name
- Org 27569
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $191
- Updated
- 2021/12/16
- Product number
- 2957
- Product name
- Org 27569
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $802
- Updated
- 2021/12/16
- Product number
- 256120
- Product name
- Org 27569
- Packaging
- 10mg
- Price
- $438
- Updated
- 2021/12/16
- Product number
- O674975
- Product name
- Org 27569
- Packaging
- 50mg
- Price
- $1045
- Updated
- 2021/12/16
- Product number
- orb181073
- Product name
- Org 27569
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1654.1
- Updated
- 2021/12/16
5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Chemical Properties,Usage,Production
Uses
Org 27569 is a drug that is a used in biological studies for structure-activity relationships of indole-carboxamides as CB1 receptor allosteric modulators.
Biological Activity
Potent CB 1 receptor allosteric modulator (pEC 50 = 8.24). Significantly increases binding of the CB 1 agonist [ 3 H]CP 55.940 (pK b = 5.67) and decreases binding of the CB 1 inverse agonist [ 3 H]SR 141716A (pK b = 5.95). Inhibits CB 1 receptor antagonist efficacy in vitro (pK b = 7.57).
storage
Store at RT
References
[1] price mr1, baillie gl, thomas a, stevenson la, easson m, goodwin r, mclean a, mcintosh l, goodwin g, walker g, westwood p, marrs j, thomson f, cowley p, christopoulos a, pertwee rg, ross ra. allosteric modulation of the cannabinoid cb1 receptor. mol pharmacol. 2005 nov;68(5):1484-95. epub 2005 aug 19.
[2] fay jf1, farrens dl. a key agonist-induced conformational change in the cannabinoid receptor cb1 is blocked by the allosteric ligand org 27569. j biol chem. 2012 sep 28;287(40):33873-82. epub 2012 jul 30.
5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Preparation Products And Raw materials
Raw materials
Preparation Products
5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide Suppliers
View Lastest Price from 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide manufacturers
- Product
- 5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide 868273-06-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-02-18