3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
- Product Name
- 3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
- CAS No.
- 227088-94-0
- Chemical Name
- 3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
- Synonyms
- AZ11645373;3-[1-[[(3'-NITRO[1;4-THIAZOLIDINEDIONE;1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2;3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione;3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione;3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione;3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-
- CBNumber
- CB42093152
- Molecular Formula
- C24H21N3O5S
- Formula Weight
- 463.512
- MOL File
- 227088-94-0.mol
3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Property
- Boiling point:
- 689.1±65.0 °C(Predicted)
- Density
- 1.362±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- solid
- pka
- 5.95±0.10(Predicted)
- color
- tan
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A7231
- Product name
- AZ11645373
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $150
- Updated
- 2022/05/15
- Product number
- 3317
- Product name
- AZ11645373
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $210
- Updated
- 2021/12/16
- Product number
- 3317
- Product name
- AZ11645373
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $861
- Updated
- 2021/12/16
- Product number
- A795150
- Product name
- AZ11645373
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 162707
- Product name
- AZ 11645373
- Packaging
- 5mg
- Price
- $403
- Updated
- 2021/12/16
3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Chemical Properties,Usage,Production
Uses
A selective P2X7 receptor antagonist.
Biological Activity
Potent and selective human P2X 7 antagonist (K B values are 5 - 7 and > 10,000 nM at hP2X 7 and rP2X 7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1 β release in vitro (K B values are 15 and 92 nM respectively).
storage
Store at +4°C
References
1. stokes l, jiang lh, alcaraz l, et al. characterization of a selective and potent antagonist of human p2x(7) receptors, az11645373. british journal of pharmacology. 2006;149(7):880-887.