ChemicalBook > CAS DataBase List > [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-

Product Name
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-
CAS No.
945526-43-2
Chemical Name
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-
Synonyms
ISCK03;ISCK 03; ISCK-03;C-KIT INHIBITOR II;Stem-Cell Factor/c-Kit Inhibitor;SteM-Cell Factor/c-Kit Inhibitor, ISCK03;T-Butylphenyl Imidazolylphenyl Sulfonamide;[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide;4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide;inhibit,SCFR,c-Kit,ISCK-03,CD117,Inhibitor,ISCK03,ISCK 03;N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide
CBNumber
CB42098935
Molecular Formula
C19H21N3O2S
Formula Weight
355.45
MOL File
945526-43-2.mol
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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Property

storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in ethanol or DMSO
form 
solid
color 
yellow
Sensitive 
Light Sensitive
InChIKey
XQABBHBFHWHMKF-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I6410
Product name
ISCK03
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
I6410
Product name
ISCK03
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$440
Updated
2024/03/01
Alfa Aesar
Product number
J65114
Product name
Stem-Cell Factor/c-Kit Inhibitor
Packaging
10mg
Price
$139
Updated
2023/06/20
Alfa Aesar
Product number
J65114
Product name
Stem-Cell Factor/c-Kit Inhibitor
Packaging
50mg
Price
$459
Updated
2021/12/16
Cayman Chemical
Product number
15781
Product name
ISCK03
Purity
≥95%
Packaging
1mg
Price
$34
Updated
2024/03/01
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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Chemical Properties,Usage,Production

Uses

Inhibits in vitro phosphorylation of c-Kit. Also inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells

Biological Activity

isck03 is an inhibitor of scf-mediated c-kit activation.the signaling downstream of scf/c-kit plays a key role in the development of various mammalian cells, such as mast cells, melanocytes, primordial germ cells, and hematopoietic progenitor cells.

in vitro

previous study showed that the pretreatment of 501mel cells with isck03 could dose-dependently inhibit scf-induced c-kit phosphorylation. isck03 could also inhibit the phosphorylation of p44/42 erk mitogen-activated protein kinase that was known to be involved in scf/c-kit downstream signaling. however, isck03 was not able to inhibit hepatocyte growth factor-induced phosphorylation of p44/42 erk proteins [1].

in vivo

to determine the in vivo efficacy, isck03was orally administered to depilated c57bl/6 mice. results showed that the oral administration of isck03 could induce the dose-dependent depigmentation of newly regrown hair, and this was reversed with cessation of isck03 treatment. in addition, the topical application of isck03 could promote the depigmentation of uv-induced hyperpigmented spots on n brownish guinea pig skin. moreover, the fontana–masson staining analyses showed epidermal melanin was diminished in spots treated with isck03 [1].

References

[1] y. j. na, h. s. baek, s. m. ahn, et al. [4-t-butylphenyl]-n-(4-imidazol-1-yl phenyl)sulfonamide (isck03) inhibits scf/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. biochemical pharmacology 74(5), 780-786 (2007).

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Suppliers

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View Lastest Price from [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- manufacturers

Career Henan Chemical Co
Product
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- 945526-43-2
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

945526-43-2, [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-Related Search:


  • [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-
  • 4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
  • Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem
  • C-KIT INHIBITOR II
  • ISCK03
  • SteM-Cell Factor/c-Kit Inhibitor, ISCK03
  • [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide
  • Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]
  • ISCK 03; ISCK-03
  • Stem-Cell Factor/c-Kit Inhibitor
  • inhibit,SCFR,c-Kit,ISCK-03,CD117,Inhibitor,ISCK03,ISCK 03
  • T-Butylphenyl Imidazolylphenyl Sulfonamide
  • N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide
  • 945526-43-2
  • API