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Ranolazine-d5

Product Name
Ranolazine-d5
CAS No.
1092804-87-9
Chemical Name
Ranolazine-d5
Synonyms
Ranolazine-d5;N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl-1,1,2,3,3-d5]-1-piperazineacetamide
CBNumber
CB42104247
Molecular Formula
C24H28D5N3O4
Formula Weight
432.56732889
MOL File
1092804-87-9.mol
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Ranolazine-d5 Property

storage temp. 
Store at -20°C
solubility 
Dichloromethane: Soluble; Methanol: Soluble
form 
A solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25424
Product name
Ranolazine-d5
Purity
≥99% deuterated forms (d1-d5)
Packaging
500μg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
25424
Product name
Ranolazine-d5
Purity
≥99% deuterated forms (d1-d5)
Packaging
1mg
Price
$434
Updated
2024/03/01
AK Scientific
Product number
2996DC
Product name
N-(2,6-Dimethylphenyl)-2-[4-[1,1,2,3,3-pentadeuterio-2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
Packaging
1mg
Price
$559
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0007103
Product name
RANOLAZINE-D5
Purity
95.00%
Packaging
1MG
Price
$739.2
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0007103
Product name
RANOLAZINE-D5
Purity
95.00%
Packaging
10MG
Price
$1871.1
Updated
2021/12/16
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Ranolazine-d5 Chemical Properties,Usage,Production

Description

Ranolazine-d5 is intended for use as an internal standard for the quantification of ranolazine by GC- or LC-MS. Ranolazine is a piperazine derivative with cardioprotective activity.1,2,3,4 It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).1,2 Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).2 In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.3 Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .4

References

1. Shryock, J.C., and Belardinelli, L. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium Br. J. Pharmacol. 153(6),1128-1132(2008).
2. Verrier, R.L., Kumar, K., Nieminen, T., et al. Mechanisms of ranolazine’s dual protection against atrial and ventricular fibrillation Europace 15(3),317-324(2013).
3. Wang, W.Q., Robertson, C., Dhalla, A.K., et al. Antitorsadogenic effects of (±)-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits J. Pharmacol. Exp. Ther. 325(3),875-881(2008).
4. Tocchetti, C.G., Carpi, A., Coppola, C., et al. Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction Eur. J. Heart Fail. 16(4),358-366(2014).

Ranolazine-d5 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ranolazine-d5 Suppliers

Canada 1 China 5 United States 1 Global 7
TLC PharmaChem Inc.
Tel
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Fax
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Email
research@tlcpharmachem.com
Country
Canada
ProdList
921
Advantage
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1092804-87-9, Ranolazine-d5Related Search:

Ranolazine

  • Ranolazine-d5
  • N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl-1,1,2,3,3-d5]-1-piperazineacetamide
  • 1092804-87-9
  • C24H28N3O4D5