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3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid

Product Name
3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid
CAS No.
187949-86-6
Chemical Name
3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid
Synonyms
3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid;3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid;2-Thiophenecarboxylic acid, 3-amino-5-(4-chlorophenyl)-
CBNumber
CB42129455
Molecular Formula
C11H8ClNO2S
Formula Weight
253.7
MOL File
187949-86-6.mol
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3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid Property

Melting point:
146 °C
Boiling point:
507.3±50.0 °C(Predicted)
Density 
1.483
pka
3.95±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A595885
Product name
3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylicacid
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA139790
Product name
3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid
Packaging
500mg
Price
$80
Updated
2021/12/16
AK Scientific
Product number
W4054
Product name
3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylicacid
Packaging
5g
Price
$155
Updated
2021/12/16
AK Scientific
Product number
W4054
Product name
3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylicacid
Packaging
10g
Price
$212
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA139790
Product name
3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid
Packaging
1g
Price
$140
Updated
2021/12/16
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3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid Chemical Properties,Usage,Production

Synthesis

91076-93-6

187949-86-6

General procedure for the synthesis of 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid from methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate: a) Hydrolysis reaction: 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid methyl ester (2.00 g, 7.47 mmol) was dissolved in a mixture of 50 mL of water and 50 mL of methanol containing KOH (2.0 g, 36 mmol), and the reaction was carried out at reflux for 2 hours. Upon completion of the reaction, the methanol was removed by evaporation, and the residue was diluted with water to twice the original volume and washed with ethyl acetate. The aqueous layer was acidified with aqueous NaHSO4 to pH < 7. The precipitate precipitated was collected by filtration, washed with water and dried to give 1.85 g (98% yield) of the target product 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid. The product was characterized by 1H NMR (DMSO-d6): δ 7.62 (m, 2H), 7.48 (m, 2H), 6.96 (s, 1H).

References

[1] Patent: WO2007/11284, 2007, A1. Location in patent: Page/Page column 22-23
[2] Patent: WO2007/11285, 2007, A1. Location in patent: Page/Page column 19
[3] Patent: WO2007/11286, 2007, A1. Location in patent: Page/Page column 20
[4] Patent: WO2005/66163, 2005, A2. Location in patent: Page/Page column 109
[5] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 223 - 231

3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid Suppliers

China 34 India 1 Switzerland 1 United Kingdom 2 United States 5 Global 43
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187949-86-6, 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acidRelated Search:

Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate 3-AMINO-5-(2,4-DICHLORO-PHENYL)-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER ETHYL 3-AMINO-5-(4-CHLOROPHENYL)THIOPHE& 3-AMINO-5-(4-CHLOROPHENYL)-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER BUTTPARK 102\40-32 BUTTPARK 102\40-57 METHYL 5-(4-CHLOROPHENYL)-3-[(2,3,3-TRICHLOROACRYLOYL)AMINO]THIOPHENE-2-CARBOXYLATE 3-TERT-BUTOXYCARBONYLAMINO-5-(4-CHLOROPHENYL)-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID 3-TERT-BUTOXYCARBONYLAMINO-5-(4-CHLOROPHENYL)THIOPHENE-2-CARBOXYLIC ACID ETHYL 3-AMINO-5-(2,4-DICHLORO-5-FLUOROPHENYL)THIOPHENE-2-CARBOXYLATE BUTTPARK 103\40-41 BUTTPARK 102\40-26 ETHYL 5-(4-CHLOROPHENYL)-3-[(CYANOACETYL)AMINO]THIOPHENE-2-CARBOXYLATE BUTTPARK 103\40-53 BUTTPARK 103\40-43 BUTTPARK 102\40-56 BUTTPARK 102\40-59 ETHYL 3-[(CHLOROACETYL)AMINO]-5-(4-CHLOROPHENYL)THIOPHENE-2-CARBOXYLATE

  • 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylic acid
  • 3-Amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid
  • 2-Thiophenecarboxylic acid, 3-amino-5-(4-chlorophenyl)-
  • 187949-86-6