D-erythro-C18-Dihydro-D-sphingosine
- Product Name
- D-erythro-C18-Dihydro-D-sphingosine
- CAS No.
- 764-22-7
- Chemical Name
- D-erythro-C18-Dihydro-D-sphingosine
- Synonyms
- (2S,3R)-;SPC-102860;Sphinganie;SPHINGANINE;Sphinganine (d18:0);D-erythro-sphinganine;Dihydro-D-erythro-Sphingosine;D-ERYTHRO-DIHYDRO-D-SPHINGOSINE;(2S,3R)-2-aminooctadecane-1,3-diol;D-erythro-C18-Dihydro-D-sphingosine
- CBNumber
- CB42130435
- Molecular Formula
- C18H39NO2
- Formula Weight
- 301.51
- MOL File
- 764-22-7.mol
D-erythro-C18-Dihydro-D-sphingosine Property
- Melting point:
- 70-72°C
- Boiling point:
- 446.2±25.0 °C(Predicted)
- Density
- 0.927±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble25mg/mL (warm)
- pka
- 12.57±0.45(Predicted)
- form
- White to off-white solid.
- color
- white
- biological source
- synthetic (organic)
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- InChI
- InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
- InChIKey
- OTKJDMGTUTTYMP-ZWKOTPCHSA-N
- SMILES
- C(O)[C@H](N)[C@H](O)CCCCCCCCCCCCCCC
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- D3314
- Product name
- D-erythro-Dihydrosphingosine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2025/07/31
- Product number
- D3314
- Product name
- D-erythro-Dihydrosphingosine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $542
- Updated
- 2025/07/31
- Product number
- 10007945
- Product name
- Sphinganine (d18:0)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 10007945
- Product name
- Sphinganine (d18:0)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 10007945
- Product name
- Sphinganine (d18:0)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $155
- Updated
- 2024/03/01
D-erythro-C18-Dihydro-D-sphingosine Chemical Properties,Usage,Production
Description
Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1?and phospholipases A2 and D2.
Chemical Properties
White Powder
Uses
Sphinganine (d18:0) has been used:
- as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides
- as a medium supplement to test its effect on growth of yeast cells
- in the preparation of bovine serum albumin lipid complex to investigate its effect on non-lysosomal - glucosylceramidase β2 (GBA2) inhibition
Uses
Biosynthetic precursor of Sphingosine. Inhibits protein kinase C.
Definition
ChEBI: Sphinganine is a 2-aminooctadecane-1,3-diol having (2S,3R)-configuration. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a human metabolite and a mouse metabolite. It is a conjugate base of a sphinganine(1+).
General Description
Sphinganine (d18:0) is a substrate for the enzyme ceramide desaturase. It is synthesized indirectly due to the interconversion of supplemented glycine to serine. Sphinganine (d18:0) is catabolized to ceramide.
Biochem/physiol Actions
Sphinganine (d18:0) levels are not altered in hereditary sensory neuropathy type 1 cells. Accumulation of d18:0 is observed in tumor hypoxia. It is useful as a biomarker for studying microbial diversity.
References
[1] JR. A H M. Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds[J]. Biochemistry Biochemistry, 1989, 28 8: 3138-3145. DOI:10.1021/bi00434a004
[2] RICHARD C. FRANSON . Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine[J]. Biochimica et biophysica acta. Molecular cell research, 1992, 1136 2: Pages 169-174. DOI:10.1016/0167-4889(92)90253-8
D-erythro-C18-Dihydro-D-sphingosine Preparation Products And Raw materials
Raw materials
Preparation Products
D-erythro-C18-Dihydro-D-sphingosine Suppliers
- Tel
- 021-61150625 17721318029
- Fax
- 021-26018649
- info@renshipharma.com
- Country
- China
- ProdList
- 161
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 021-68187180 13681683526
- Fax
- 021-68187179
- lchen@syncozymes.com
- Country
- China
- ProdList
- 317
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4720
- Advantage
- 55
- Tel
- +49 5662 408730
- Fax
- +49 5662 4087320
- info@synchem.de
- Country
- Germany
- ProdList
- 4705
- Advantage
- 70
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7778
- Advantage
- 56
- Tel
- 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15873
- Advantage
- 55
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 1-516-6625404
- Fax
- 1-516-927-0118
- support@alfa-chemistry.com
- Country
- United States
- ProdList
- 9171
- Advantage
- 60
View Lastest Price from D-erythro-C18-Dihydro-D-sphingosine manufacturers
- Product
- Sphinganie 764-22-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥90%
- Supply Ability
- 20000kgs
- Release date
- 2025-09-29
- Product
- Sphinganine 764-22-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥90%
- Supply Ability
- 20000kgs
- Release date
- 2025-09-29