D-erythro-C18-Dihydro-D-sphingosine
- Product Name
- D-erythro-C18-Dihydro-D-sphingosine
- CAS No.
- 764-22-7
- Chemical Name
- D-erythro-C18-Dihydro-D-sphingosine
- Synonyms
- (2S,3R)-;SPC-102860;SPHINGANINE;Sphinganine (d18:0);D-erythro-sphinganine;Dihydro-D-erythro-Sphingosine;D-ERYTHRO-DIHYDRO-D-SPHINGOSINE;(2S,3R)-2-aminooctadecane-1,3-diol;D-erythro-C18-Dihydro-D-sphingosine;(2S,3R)-2-azanyloctadecane-1,3-diol
- CBNumber
- CB42130435
- Molecular Formula
- C18H39NO2
- Formula Weight
- 301.51
- MOL File
- 764-22-7.mol
D-erythro-C18-Dihydro-D-sphingosine Property
- Melting point:
- 70-72°C
- Boiling point:
- 446.2±25.0 °C(Predicted)
- Density
- 0.927±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble25mg/mL (warm)
- pka
- 12.57±0.45(Predicted)
- form
- White to off-white solid.
- color
- white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- D3314
- Product name
- D-erythro-Dihydrosphingosine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- D3314
- Product name
- D-erythro-Dihydrosphingosine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $527
- Updated
- 2024/03/01
- Product number
- 10007945
- Product name
- Sphinganine (d18:0)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 10007945
- Product name
- Sphinganine (d18:0)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 10007945
- Product name
- Sphinganine (d18:0)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $155
- Updated
- 2024/03/01
D-erythro-C18-Dihydro-D-sphingosine Chemical Properties,Usage,Production
Description
Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1?and phospholipases A2 and D2.
Chemical Properties
White Powder
Uses
Sphinganine (d18:0) has been used:
- as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides
- as a medium supplement to test its effect on growth of yeast cells
- in the preparation of bovine serum albumin lipid complex to investigate its effect on non-lysosomal - glucosylceramidase β2 (GBA2) inhibition
Uses
Biosynthetic precursor of Sphingosine. Inhibits protein kinase C.
Definition
ChEBI: Sphinganine is a 2-aminooctadecane-1,3-diol having (2S,3R)-configuration. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a human metabolite and a mouse metabolite. It is a conjugate base of a sphinganine(1+).
General Description
Sphinganine (d18:0) is a substrate for the enzyme ceramide desaturase. It is synthesized indirectly due to the interconversion of supplemented glycine to serine. Sphinganine (d18:0) is catabolized to ceramide.
Biochem/physiol Actions
Sphinganine (d18:0) levels are not altered in hereditary sensory neuropathy type 1 cells. Accumulation of d18:0 is observed in tumor hypoxia. It is useful as a biomarker for studying microbial diversity.
References
1) Merrill?et al. (1989),?Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for cellular effects of these compounds; Biochemistry,?28?3138 2) Franson?et al. (1992),?Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine, Biochim. Biophys. Acta?1136?169
D-erythro-C18-Dihydro-D-sphingosine Preparation Products And Raw materials
Raw materials
Preparation Products
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