PROFLAVINE

Product Name: PROFLAVINE
CAS No.: 92-62-6
Chemical Name: PROFLAVINE
Synonyms: PROFLAVINE;Isoflabase;6-Diaminoacridine;3,6-Aiaminoacridine;3,6-Acridinediamine;(6-aminoacridin-3-yl)amine;Inhibitor,Proflavine,Whole,Bacterial,blood,inward,inhibit,channel,rectifier,G protein,gated
CBNumber: CB42131119
Molecular Formula: C13H11N3
Formula Weight: 209.25
MOL File: 92-62-6.mol

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PROFLAVINE Property

Melting point:: 281° (Schpff); mp 288° (Albert)
Boiling point:: 338.61°C (rough estimate)
Density: 1.1847 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Water Solubility: Soluble in water
solubility: DMSO: 23 mg/mL (109.92 mM);Ethanol: 2 mg/mL (9.56 mM)
form: powder to crystal
pka: 9.65(at 20℃)
color: Light yellow to Brown
EPA Substance Registry System: 3,6-Acridinediamine (92-62-6)

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Safety

HS Code: 2933.99.4600
Hazardous Substances Data: 92-62-6(Hazardous Substances Data)
Toxicity: LD50 s.c. in mice: 0.14 g/kg (Rubbo)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PH006894
Product name: 3,6-acridinediamine
Purity: AldrichCPR
Packaging: 25mg
Price: $172
Updated: 2023/06/20

TCI Chemical

Product number: A3219
Product name: Acridine-3,6-diamine
Packaging: 1G
Price: $123
Updated: 2024/03/01

TCI Chemical

Product number: A3219
Product name: Acridine-3,6-diamine
Packaging: 5G
Price: $368
Updated: 2024/03/01

Chem-Impex

Product number: 42558
Product name: Acridine-3,6-diamine,≥96%(HPLC)
Purity: ≥96%(HPLC)
Packaging: 5G
Price: $379.02
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573376
Product name: Proflavine
Purity: >98%
Packaging: 100mg
Price: $690.2
Updated: 2021/12/16

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PROFLAVINE Chemical Properties,Usage,Production

Definition

ChEBI: An aminoacridine that is acridine that is substituted by amino groups at positions 3 and 6. A slow-acting bacteriostat that is effective against many Gram-positive bacteria (but ineffective against spores), its salts were formerly used for treatment of bur s and infected wounds.

Safety Profile

Poison by intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also other diaminoacridine entries.

Enzyme inhibitor

This dye (FWfree-base = 209.25 g/mol; CAS 92-62-6; orange-red solid; M.P. = 281 or 288°C; soluble in water; pKa = 9.65; solutions are light sensitive; insoluble in organic solvents such as benzene, diethyl ether, and chloroform), also known as proflavin and 3,6-acridinediamine, is a mutagen that intercalates in double-stranded DNA, inhibiting both DNA and RNA biosynthesis. Proflavine can also participate in the photooxidation of proteins (e.g., dopa decarboxylase. In addition, proflavine can inhibit a number of enzymes directly. For xample scriflavine, a mixture of proflavine with 3,6-diamino-10-methylacridinium chloride, inhibits protein kinase C. Target(s): L-amino-acid oxidase; carbonic anhydrase, or carbonate dehydratase, Ki ≈ 10 mM; chymotrypsin; DNA (cytosine-5-)-methyltransferase; DNA-directed RNA polymerase; dopa decarboxylase; F1Fo ATPase, or F1Fo ATP synthase, or H+-transporting two-sector ATPase; ficain, or ficin; glutamate decarboxylase; lysozyme; monoamine oxidase; NADH:cytochrome b5 reductase; nucleoside-triphosphatase, nuclear-envelope; papain; poly(ADP-ribose) glycohydrolase; polynucleotide adenylyltransferase, or poly(A) polymerase; pyruvate kinase; RNA-directed DNA polymerase; thrombin; tRNA adenylytltransferase; tRNA (guanine-N2-)-methyltransferase; tRNA cytidylyltransferase; tRNA methyltransferases; tRNA nucleotidyltransferase; and trypsin.

Purification Methods

Proclavine (3,6-diaminoacridine) [92-62-6] M 209.2, m 284-286o, pK 1 -2.7, pK 2 0 . 5 5 , pK 3 9.49. It crystallises from aqueous MeOH. The picrate crystallises from aqueous pyridine with m ~185o. [Beilstein 22 H 487, 22 I 649, 22 II 397, 22 III/IV 5487, 22/11 V 322.] For proflavin see 3,6-diaminoacridine hydrochloride.

PROFLAVINE Preparation Products And Raw materials

Raw materials

Preparation Products

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PROFLAVINE Suppliers

Americas 1 China 32 Europe 1 India 1 Japan 1 United States 5 Global 41

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92-62-6, PROFLAVINERelated Search:

PROFLAVINE

3,6-Acridinediamine

3,6-Aiaminoacridine

Isoflabase

(6-aminoacridin-3-yl)amine

6-Diaminoacridine

Inhibitor,Proflavine,Whole,Bacterial,blood,inward,inhibit,channel,rectifier,G protein,gated

92-62-6