ChemicalBook > CAS DataBase List > 10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid

10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid

Product Name
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
CAS No.
74711-43-6
Chemical Name
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
Synonyms
Soleton;ZALTOPROFEN;Salafapinon;Zatobuprofen;Einecs 277-973-5;Zaltoprofen, >=99%;Zaltoprofen (CN100);Zaltoprofen (unspecified);Zaltoprofen, 10 mM in DMSO;CN100;SOLETON;CN-100;CN 100
CBNumber
CB42131285
Molecular Formula
C17H14O3S
Formula Weight
298.36
MOL File
74711-43-6.mol
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10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Property

Melting point:
129-1310C
Boiling point:
500.5±50.0 °C(Predicted)
Density 
1.329±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.21±0.10(Predicted)
color 
Off-White to Pale Yellow
Merck 
14,10112
InChI
InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)
InChIKey
MUXFZBHBYYYLTH-UHFFFAOYSA-N
SMILES
C(C1=CC=C2SC3=CC=CC=C3C(CC2=C1)=O)(C)C(=O)O
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Safety

RTECS 
HQ2526700
HS Code 
2934.99.4400
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
Z0021
Product name
Zaltoprofen
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
Z0021
Product name
Zaltoprofen
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$105
Updated
2025/07/31
Cayman Chemical
Product number
14662
Product name
Zaltoprofen
Purity
≥98%
Packaging
10mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
14662
Product name
Zaltoprofen
Purity
≥98%
Packaging
50mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
14662
Product name
Zaltoprofen
Purity
≥98%
Packaging
100mg
Price
$228
Updated
2024/03/01
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10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Zaltoprofen is a non-steroidal anti-inflammatory drug. It inhibits bradykinin-induced pain responses without blocking bradykinin receptors.

Uses

Anti-inflammatory activity resides in (S)-enantiomer.

Definition

ChEBI: Zaltoprofen is an organic molecular entity.

in vivo

Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats[2].
Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner[2].

Animal Model:Eight-week-old male Wistar rats were injected Bradykinin every 15 min[2]
Dosage:5, 10, 20 mg/kg
Administration:A single p.o.
Result:Inhibited bradykinin-induced nociceptive responses, with an ED50 of 9.7 mg/kg.
The duration of analgesic effect was 60-90 min.

IC 50

COX-2: 0.34 μM (IC50); COX-1: 1.3 μM (IC50)

10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Suppliers

Canada 1 China 148 India 7 Japan 1 United Kingdom 1 United States 19 Global 177
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View Lastest Price from 10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid 74711-43-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-09-20
Zhejiang J&C Biological Technology Co.,Limited
Product
Zaltoprofen 74711-43-6
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
10kg
Release date
2022-02-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid 74711-43-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

74711-43-6, 10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acidRelated Search:

Benztropine mesylate Pivalic acid Methyl salicylate Methyl 2,2-dimethylphenylacetate Tribenuron methyl Ethyl 2-(Chlorosulfonyl)acetate 4-Methylphenylacetic acid Dihydromyrcenol Methanol Methyl acrylate Dimethylbenzylcarbinyl acetate Ibuprofen Methylparaben Zaltoprofen Zalcitabine Zafirlukast ZANAMIVIR HYDRATE N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide

  • 2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoic acid
  • Zaltoprofen/ 10,11-Dihydro-alpha-Methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
  • Zaltoprofen, >=99%
  • Salafapinon
  • Soleton
  • Dibenzo(B,F)thiepin-2-acetic acid, 10,11-dihydro-alpha-methyl-10-oxo-
  • Einecs 277-973-5
  • Zaltoprofen (unspecified)
  • CAS No:74711-43-6 Dibenzo[b,f]thiepin-2-aceticacid, 10,11-dihydro-a-Methyl-10-oxo-
  • 10,11-dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
  • ZALTOPROFEN
  • CN100;SOLETON;CN-100;CN 100
  • 3-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid
  • Dibenzo[b,f]Thiepin-2-Acetic Acid
  • 2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid
  • 10,11-Dihydro-alpha-Methyl-10-oxo-dibenzo
  • Dibenzo[b,f]thiepin-2-acetic acid, 10,11-dihydro-α-methyl-10-oxo-
  • Dibenzo[b,f]thiepin-2-acetic acid, 10,11-dihydro-a-methyl-10-oxo-
  • 10,11-dihydro-α-methyl-10-oxodibenzo[b,f]thiepin-2-acetic acid
  • 10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid USP/EP/BP
  • Zaltoprofen (CN100)
  • ZaltoprofenQ: What is Zaltoprofen Q: What is the CAS Number of Zaltoprofen Q: What is the storage condition of Zaltoprofen Q: What are the applications of Zaltoprofen
  • Zatobuprofen
  • Zaltoprofen, 10 mM in DMSO
  • Dibenzo[b,f]thiepin-2-acetic acid, 10,11-dihydro-α-methyl-10-oxo-
  • Zaltoprofen: 2-(10,11-Dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic Acid
  • 74711-43-6
  • Inhibitors
  • Zaltoprofen
  • Intermediates & Fine Chemicals
  • Pharmaceuticals