4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID

Product Name: 4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID
CAS No.: 141872-46-0
Chemical Name: 4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID
Synonyms: A81282;A-81282;A 81282;Abbott 81282;4-{butyl-[2′-(1H-tetra-zol-5-yl)-biphenyl-4-ylmethyl-]amino-}-pyrimidine-5-carboxy-lic acid;4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID;4-(N-n-Butyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)amino)pyrimidine-5-carboxylic acid;5-Pyrimidinecarboxylic acid, 4-[butyl[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amino]-
CBNumber: CB4213398
Molecular Formula: C23H23N7O2
Formula Weight: 429.47
MOL File: 141872-46-0.mol

More

Less

4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID Property

Boiling point:: 707.3±70.0 °C(Predicted)
Density: 1.320±0.06 g/cm3(Predicted)
pka: 1.04±0.36(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

AHH

Product number: MT-04234
Product name: 4-[Butyl([2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl)amino]-5pyrimidinecarboxylicacid
Purity: 98%
Packaging: 1000g
Price: $335
Updated: 2021/12/16

More

Less

4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats[1].

IC 50

AT1 Receptor: 9.64 (pA2)

References

[1] Hancock AA, et al. Pharmacological characterization of Abbott-81282, a novel, non-peptide angiotensin-II antagonist selective for type-1 receptors. Life Sci. 1993;53(11):929-37. DOI:10.1016/0024-3205(93)90445-9

4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID Suppliers

China 3 South Korea 1 Sweden 1 United Kingdom 1 United States 2 Global 8

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9751
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChengDu SinoStandards Bio-Tech Co.,Ltd. ，

Tel: 028-83243028 19136088901
Email: sinostandards@163.com
Country: China
ProdList: 4976
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

141872-46-0, 4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACIDRelated Search:

5-BIPHENYL-2-YL-2H-TETRAZOLE 4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID 5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE

Abbott 81282

4-(N-n-Butyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)amino)pyrimidine-5-carboxylic acid

4-{butyl-[2′-(1H-tetra-zol-5-yl)-biphenyl-4-ylmethyl-]amino-}-pyrimidine-5-carboxy-lic acid

4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID

5-Pyrimidinecarboxylic acid, 4-[butyl[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amino]-

A 81282

A81282

A-81282

141872-46-0

C23H23N7O2