ChemicalBook > CAS DataBase List > Bendazac

Bendazac

Product Name
Bendazac
CAS No.
20187-55-7
Chemical Name
Bendazac
Synonyms
Versus;AF 983;BENDAZAC;Bindazac;Zildasac;Dogalina;Zildazac;AKOS 90683;Bendazac >Bendazac,97%
CBNumber
CB4222435
Molecular Formula
C16H14N2O3
Formula Weight
282.29
MOL File
20187-55-7.mol
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Bendazac Property

Melting point:
161-163°C
Boiling point:
424.91°C (rough estimate)
Density 
1.1658 (rough estimate)
refractive index 
1.6240 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
2.89±0.10(Predicted)
color 
Crystals from ethanol
λmax
306nm(lit.)
Merck 
14,1035
InChIKey
BYFMCKSPFYVMOU-UHFFFAOYSA-N
CAS DataBase Reference
20187-55-7(CAS DataBase Reference)
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Safety

RTECS 
AF5085000
HS Code 
2933998090
Toxicity
LD50 in mice, rats (mg/kg): 380, 304 i.v.; 355, 388 i.p.; 440, 910 s.c.; 1105, ~1200 orally (Rx Bulletin)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4223
Product name
Bendazac
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$37
Updated
2024/03/01
TCI Chemical
Product number
B4223
Product name
Bendazac
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$110
Updated
2024/03/01
TRC
Product number
B132600
Product name
Bendazac
Packaging
10g
Price
$150
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
54084
Product name
Bendazac
Packaging
5G
Price
$625
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0096016
Product name
BENDAZAC
Purity
95.00%
Packaging
5G
Price
$895.13
Updated
2021/12/16
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Bendazac Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Versus,Angelini,Italy,1970

Uses

Bendazac is a non-steroidal anti-inflammatory drug (NSAID). Bendazac is often used for joint and muscular pain. Bendazac has potential as an anti-denaturant drug for cataract and other condensation di seases as it protects proteins from denaturation induced by different agents.

Definition

ChEBI: A monocarboxylic acid that is glycolic acid in which the hydrogen attached to the 2-hydroxy group is replaced by a 1-benzyl-1H-indazol-3-yl group. Although it has anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties nd has been used for the treatment of various inflammatory skin disorders, its principal effect is to inhibit the denaturation of proteins. Its lysine salt is used in the management of cataracts.

Manufacturing Process

11 grams of the sodium salt of 1-benzyl-3-oxy-indazole are dissolved in 70 ml of absolute ethanol by heating the resulting solution to boiling and stirring. 3.5 grams of chloroacetonitrile dissolved in 5 ml of absolute ethanol are then added within 2-3 minutes and after 10 minutes a further portion of 1.7 grams of chloroacetonitrile are added. The reaction is finally brought to completion with an additional 45 minutes of boiling. The reaction mixture is allowed to cool at room temperature and is then filtered. The alcohol solution is evaporated to dryness under reduced pressure; the resulting residue is taken up again with ether and the ether solution is washed in sequence with dilute HCl, water, NaOH and water. The solution is dried on Na2SO4 and then the solvent is removed. The residue consists of (1-benzyl-indazole- 3)oxyacetonitrile which is crystallized from methanol. It has a melting point of 93°C.
1 gram of the (1-benzyl-indazole-3)oxyacetonitrile is pulverized and is added with stirring to 5 ml concentrated HCl. By heating on a boiling water bath for 2-3 minutes, the nitrile product melts and soon thereafter solidifies. The precipitate is cooled, then filtered and washed well in a mortar with water. After dissolution in 10% Na2CO3 it is precipitated again with dilute HCl. After crystallization from ethanol, 1-benzyl-indazole-3-oxyacetic acid is obtained. It has a melting point of 160°C.

Therapeutic Function

Antiinflammatory

Safety Profile

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. When heated to decomposition itemits toxic fumes of NOx.

Bendazac Preparation Products And Raw materials

Raw materials

Preparation Products

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Bendazac Suppliers

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View Lastest Price from Bendazac manufacturers

Hebei Duling International Trade Co. LTD
Product
Bendazac 20187-55-7
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50 tons
Release date
2023-04-17
Shaanxi Dideu Medichem Co. Ltd
Product
Bendazac 20187-55-7
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-29
Xiamen Wonderful Bio Technology Co., Ltd.
Product
Bendazac 20187-55-7
Price
US $120.00/KG
Min. Order
1250KG
Purity
99%
Supply Ability
330T
Release date
2023-06-06

20187-55-7, BendazacRelated Search:

N,N-Dimethylbenzylamine Benzyl chloride Midazolam maleate salt Benzyltrimethylammonium chloride BENZYL GLYCIDYL ETHER Benzyl salicylate Ethyl 2-(Chlorosulfonyl)acetate Benzyltriethylammonium chloride Ascoric Acid Acetic anhydride Phenylacetic acid Phenylacetone Bendazac Lysine,BENDAZAC LYSINE UV,BENDAZAC L-LYSINE,BENDAZAC L-LYSINE SALT,BENDAZAC LYSINE 2H2O BENDAZAC SODIUM SALT,Bendazac Sodium Indazole Bendazac ANTI-BENDAZAC ANTI-BENDAZAC, 5-OH

  • BENDAZAC
  • BENDAZAC ACID
  • AKOS 90683
  • [[1-(phenylmethyl)-1h-indazol-3-yl]oxy]acetic acid
  • 2-(1-BENZYL-1H-INDAZOL-3-YLOXY)ACETIC ACID
  • (1-BENZYL-1H-INDAZOL-3-YLOXY)-ACETIC ACID
  • [[Benzyl-[1H]-indazol-3-yl] oxy] acetic acid
  • BENDAZAC AND ITS SODIUM SALT
  • bendazolic acid
  • Bindazac
  • Versus
  • Zildasac
  • 1-Benzylindazole-3-oxyacetic Acid
  • AF 983
  • Dogalina
  • Zildazac
  • 2-[[1-(phenylmethyl)-3-indazolyl]oxy]acetic acid
  • Bendazac &gt
  • Bendazac,97%
  • Acetic acid, 2-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-
  • [(1-Benzyl-3-indazolyl)oxy]acetic Acid
  • 1-Benzyl-3-[1-(carboxy)methoxy]indazole
  • Bendazac USP/EP/BP
  • 20187-55-7
  • pharmacetical
  • API
  • bc0001