1-Methyl-1H-1,2,4-triazol-3-amine
- Product Name
- 1-Methyl-1H-1,2,4-triazol-3-amine
- CAS No.
- 49607-51-4
- Chemical Name
- 1-Methyl-1H-1,2,4-triazol-3-amine
- Synonyms
- 1-methyl-1,2,4-triazol-3-amine;3-Amino-1-methyl-1,2,4-triazole;1-Methyl-1H-1,2,4-triazol-3-amine;3-Amino-1-methyl-1H-1,2,4-triazole;1H-1,2,4-Triazol-3-amine, 1-methyl-;1-methyl-1H-1,2,4-triazol-3-amine(SALTDATA: HCl)
- CBNumber
- CB42227096
- Molecular Formula
- C3H6N4
- Formula Weight
- 98.11
- MOL File
- 49607-51-4.mol
1-Methyl-1H-1,2,4-triazol-3-amine Property
- Melting point:
- 81-86℃
- Boiling point:
- 281.9±23.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- 5.15±0.10(Predicted)
- color
- Pale Yellow to Light Yellow
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- M218815
- Product name
- 1-Methyl-1h-1,2,4-triazol-3-amine
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 6721AB
- Product name
- 1-Methyl-1H-1,2,4-triazol-3-amine
- Packaging
- 1g
- Price
- $239
- Updated
- 2021/12/16
- Product number
- P000133507
- Product name
- 1-Methyl-1H-1,2,4-triazol-3-amine
- Purity
- 97+%
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- P000133507
- Product name
- 1-Methyl-1H-1,2,4-triazol-3-amine
- Purity
- 97+%
- Packaging
- 250mg
- Price
- $62
- Updated
- 2021/12/16
- Product number
- P000133507
- Product name
- 1-Methyl-1H-1,2,4-triazol-3-amine
- Purity
- 97+%
- Packaging
- 5g
- Price
- $477
- Updated
- 2021/12/16
1-Methyl-1H-1,2,4-triazol-3-amine Chemical Properties,Usage,Production
Uses
N2-Methylpyridine-2,3-diamine is a useful reagent in synthesis of imidazopyridines, which show tuberculostatic activity.
Synthesis
26621-45-4
49607-51-4
General procedure for the synthesis of 1-methyl-1H-1,2,4-triazol-3-amine from 1-methyl-3-nitro-1H-1,2,4-triazole: Example H; 1-methyl-1H-[1,2,4]triazol-3-ylamine; 1-methyl-3-nitro-1H-1,2,4-triazole (613 mg, 4.8 mmol) synthesized according to the method described by R.W. Middleton et al. (Synthesis 1984, 740-3) was dissolved in 6 mL of methanol. 10% palladium carbon catalyst (51 mg) and hydrazine monohydrate (543 mg, 11 mmol) were added. The reaction mixture was refluxed for 1.5 hours. Upon completion of the reaction, the palladium carbon was removed by filtration and the catalyst was washed with methanol. The solvent was evaporated to afford 1-methyl-1H-1,2,4-triazol-3-amine (469 mg, 99% yield) as a white solid.
References
[1] Patent: US2006/160857, 2006, A1. Location in patent: Page/Page column 55
[2] Patent: JP5829520, 2015, B2. Location in patent: Paragraph 0498
[3] Journal of the American Chemical Society, 2017, vol. 139, # 3, p. 1261 - 1274
[4] Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 10, p. 1935 - 1940
[5] Zhurnal Organicheskoi Khimii, 1988, vol. 24, # 10, p. 2145 - 2151
1-Methyl-1H-1,2,4-triazol-3-amine Preparation Products And Raw materials
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