2-MORPHOLIN-4-YL-2-OXOETHANOL
Application- Product Name
- 2-MORPHOLIN-4-YL-2-OXOETHANOL
- CAS No.
- 51068-78-1
- Chemical Name
- 2-MORPHOLIN-4-YL-2-OXOETHANOL
- Synonyms
- 4-(Hydroxyacetyl)morpholine;2-MORPHOLIN-4-YL-2-OXOETHANOL;2-HYDROXY-1-MORPHOLINOETHANONE;2-hydroxy-1-(4-morpholinyl)ethanone;2-hydroxy-1-(morpholin-4-yl)ethanone;Ethanone, 2-hydroxy-1-(4-morpholinyl)-;2-Hydroxy-1-(Morpholin-4-Yl)Ethan-1-One
- CBNumber
- CB4228109
- Molecular Formula
- C6H11NO3
- Formula Weight
- 145.16
- MOL File
- 51068-78-1.mol
2-MORPHOLIN-4-YL-2-OXOETHANOL Property
- Melting point:
- 80-83 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 326.1±37.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.07±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H11NO3/c8-5-6(9)7-1-3-10-4-2-7/h8H,1-5H2
- InChIKey
- PHCSTEJVICOGEJ-UHFFFAOYSA-N
- SMILES
- C(=O)(N1CCOCC1)CO
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H948963
- Product name
- 2-hydroxy-1-(morpholin-4-yl)ethan-1-one
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CHM0378187
- Product name
- 2-HYDROXY-1-(MORPHOLIN-4-YL)ETHAN-1-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.74
- Updated
- 2021/12/16
- Product number
- 4913AQ
- Product name
- 2-hydroxy-1-morpholin-4-ylethanone
- Packaging
- 5g
- Price
- $514.4
- Updated
- 2021/12/16
- Product number
- 4913AQ
- Product name
- 2-hydroxy-1-morpholin-4-ylethanone
- Packaging
- 10g
- Price
- $798.8
- Updated
- 2021/12/16
- Product number
- A231662
- Product name
- 2-Hydroxy-1-morpholinoethanone
- Purity
- 97%
- Packaging
- 250mg
- Price
- $6
- Updated
- 2021/12/16
2-MORPHOLIN-4-YL-2-OXOETHANOL Chemical Properties,Usage,Production
Application
2-Morphyrin-4-yl-2-oneethanol is an N-substituted ethanolamide, a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.
Synthesis
Step I. Synthesis of 2,2-dimethyl-1,3-dioxolan-4-one
Concentrated sulfuric acid (1 mL) was added to a solution of ethanoic acid (6.77 g, 89 mmol) in anhydrous acetone (40 mL) at 5 ??C and the mixture was stirred for 30 min at this temperature. It was then added to crushed ice and neutralized with sodium bicarbonate powder and extracted with dichloromethane (100 mL). The organic layer was dried with anhydrous sodium sulfate and the solvent was removed under reduced pressure to give 3.2 g 1 in 48% yield as a pure oily compound.
Step II. Synthesis of 2-morpholin-4-yl-2-one ethanol
A mixture of 2,2-dimethyl-1,3-dioxolan-4-one (116 mg, 1 mmol) and morpholine (87 mg, 1 mmol) in dichloromethane (5 mL) was stirred in argon at ambient temperature overnight and the solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate to give 44 mg of 2-morpholin-4-yl-2-one ethanol.
2-MORPHOLIN-4-YL-2-OXOETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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