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2-MORPHOLIN-4-YL-2-OXOETHANOL

Application
Product Name
2-MORPHOLIN-4-YL-2-OXOETHANOL
CAS No.
51068-78-1
Chemical Name
2-MORPHOLIN-4-YL-2-OXOETHANOL
Synonyms
4-(Hydroxyacetyl)morpholine;2-MORPHOLIN-4-YL-2-OXOETHANOL;2-HYDROXY-1-MORPHOLINOETHANONE;2-hydroxy-1-(4-morpholinyl)ethanone;2-hydroxy-1-(morpholin-4-yl)ethanone;Ethanone, 2-hydroxy-1-(4-morpholinyl)-;2-Hydroxy-1-(Morpholin-4-Yl)Ethan-1-One
CBNumber
CB4228109
Molecular Formula
C6H11NO3
Formula Weight
145.16
MOL File
51068-78-1.mol
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2-MORPHOLIN-4-YL-2-OXOETHANOL Property

Melting point:
80-83 °C(Solv: ethyl acetate (141-78-6))
Boiling point:
326.1±37.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
13.07±0.10(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C6H11NO3/c8-5-6(9)7-1-3-10-4-2-7/h8H,1-5H2
InChIKey
PHCSTEJVICOGEJ-UHFFFAOYSA-N
SMILES
C(=O)(N1CCOCC1)CO
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
H948963
Product name
2-hydroxy-1-(morpholin-4-yl)ethan-1-one
Packaging
50mg
Price
$65
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0378187
Product name
2-HYDROXY-1-(MORPHOLIN-4-YL)ETHAN-1-ONE
Purity
95.00%
Packaging
5MG
Price
$498.74
Updated
2021/12/16
AK Scientific
Product number
4913AQ
Product name
2-hydroxy-1-morpholin-4-ylethanone
Packaging
5g
Price
$514.4
Updated
2021/12/16
AK Scientific
Product number
4913AQ
Product name
2-hydroxy-1-morpholin-4-ylethanone
Packaging
10g
Price
$798.8
Updated
2021/12/16
Ambeed
Product number
A231662
Product name
2-Hydroxy-1-morpholinoethanone
Purity
97%
Packaging
250mg
Price
$6
Updated
2021/12/16
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2-MORPHOLIN-4-YL-2-OXOETHANOL Chemical Properties,Usage,Production

Application

2-Morphyrin-4-yl-2-oneethanol is an N-substituted ethanolamide, a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.

Synthesis

Step I. Synthesis of 2,2-dimethyl-1,3-dioxolan-4-one

Concentrated sulfuric acid (1 mL) was added to a solution of ethanoic acid (6.77 g, 89 mmol) in anhydrous acetone (40 mL) at 5 ??C and the mixture was stirred for 30 min at this temperature. It was then added to crushed ice and neutralized with sodium bicarbonate powder and extracted with dichloromethane (100 mL). The organic layer was dried with anhydrous sodium sulfate and the solvent was removed under reduced pressure to give 3.2 g 1 in 48% yield as a pure oily compound.

Step II. Synthesis of 2-morpholin-4-yl-2-one ethanol

A mixture of 2,2-dimethyl-1,3-dioxolan-4-one (116 mg, 1 mmol) and morpholine (87 mg, 1 mmol) in dichloromethane (5 mL) was stirred in argon at ambient temperature overnight and the solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate to give 44 mg of 2-morpholin-4-yl-2-one ethanol.

2-MORPHOLIN-4-YL-2-OXOETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-MORPHOLIN-4-YL-2-OXOETHANOL Suppliers

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