ChemicalBook > CAS DataBase List > CALMIDAZOLIUM CHLORIDE

CALMIDAZOLIUM CHLORIDE

Product Name
CALMIDAZOLIUM CHLORIDE
CAS No.
57265-65-3
Chemical Name
CALMIDAZOLIUM CHLORIDE
Synonyms
R 24571;CALMIDAZOLIUM;COMPOUND 48/80;Calimidazoline;COMPOUND R24571;R 24571 CHLORIDE;Calmidazolium chlori;CALMIDAZOLIUM CHLORIDE;Calmidazolium chloride,99%;CALMODULIN INHIBITOR R 24571
CBNumber
CB4231628
Molecular Formula
C31H23Cl7N2O
Formula Weight
687.69
MOL File
57265-65-3.mol
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CALMIDAZOLIUM CHLORIDE Property

Melting point:
172-176 °C
storage temp. 
2-8°C
solubility 
Soluble to 100 mM in DMSO and to 100 mM in ethanol
form 
solid
color 
white
Water Solubility 
Soluble in dimethyl sulfoxide, ethanol. methanol, chloroform, and propylene glycol. Insoluble in water.
BRN 
6470244
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Safety

Safety Statements 
22-24/25
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
Gk2402500
F 
3-8-10
HS Code 
29332990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C3930
Product name
Calmidazolium chloride
Purity
solid
Packaging
5mg
Price
$234
Updated
2025/07/31
Sigma-Aldrich
Product number
C2313
Product name
Compound 48/80
Packaging
100MG
Price
$136
Updated
2025/07/31
Sigma-Aldrich
Product number
C2313
Product name
Compound 48/80
Packaging
250MG
Price
$226
Updated
2025/07/31
Sigma-Aldrich
Product number
C2313
Product name
Compound 48/80
Packaging
1G
Price
$680
Updated
2025/07/31
Sigma-Aldrich
Product number
208665
Product name
Calmidazolium Chloride
Purity
A cell-permeable calmodulin antagonist.
Packaging
10mg
Price
$167
Updated
2023/01/07
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CALMIDAZOLIUM CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+?transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+?influx distinct from store-operated Ca2+?entry and unaccompanied by Ca2+?store depletion, mobilizing stores and evoking a Ca2+?signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.

General Description

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.

Biological Activity

Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca 2+ -transporting ATPase with IC 50 values of 0.15 and 0.35 μ M respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

Biochem/physiol Actions

Inhibitor of calmodulin-regulated enzymes. It is also believed to directly block calcium channels in smooth muscle cells.

storage

+4°C

CALMIDAZOLIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CALMIDAZOLIUM CHLORIDE Suppliers

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57265-65-3, CALMIDAZOLIUM CHLORIDERelated Search:

1-Isopropylimidazole (S)-1-(4-Chlorophenyl)ethylamine 1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE 2,4-DICHLORO-ALPHA-METHYLBENZYL ALCOHOL (R)-1-(4-CHLOROPHENYL)ETHYLAMINE Miconazole Econazole 2,2',4,4'-TETRACHLORODIBENZYL ETHER alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 1-Ethyl-3-methylimidazolium chloride 2-AMINO-1-(4-CHLORO-PHENYL)-ETHANOL HCL CHEMBRDG-BB 9070890 1,3-DIMETHYLIMIDAZOLIUM CHLORIDE 2-HYDROXY-2-(2-CHLOROPHENYL)ETHYLAMINE HYDROCHLORIDE 1-Phenyl-2-(1-imidazolyl)ethanol CALMIDAZOLIUM CHLORIDE 2-Amino-1-(4-chlorophenyl)ethan-1-ol 4-Chloro-alpha-methylbenzylamine

  • CALMODULIN INHIBITOR R 24571
  • CALMIDAZOLIUM
  • CALMIDAZOLIUM CHLORIDE
  • COMPOUND R24571
  • COMPOUND 48/80
  • COMPOUND 48/80 TRIHYDROCHLORIDE
  • R 24571
  • R 24571 CHLORIDE
  • 1-[bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride
  • R 24571, 1-[bis(4-Chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride, 1-[Bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride
  • 1-[BIS(P-CHLOROPHENYL)METHYL]-3-[2-(2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY)PHENETHYL)]IMIDAZOLIUM CHLORIDE
  • 1-[BIS(P-CHLOROPHENYL)METHYL]-3-[2,4-DICHLORO-BETA-(2,4 DICHLOROBENZYLOXY) PHENETHYL]-IMIDAZOLIUM CHLORIDE
  • [1-BIS-P-CHLOROPHENYL) METHYL]-3-[2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY) PHENYL]-IMIDAZOLIUM CHLORIDE
  • 1-[BIS-(4-CHLOROPHENYL)METHYL]-3-[2-(2,4-DICHLOROPHENYL)-2-[(2,4-DICHLOROPHENYL)METHOXY]-ETHYL]-1H-IMIDAZOLIUM CHLORIDE
  • 1-[BIS(4-CHLOROPHENYL)METHYL]-3-[2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY)PHENETHYL]IMIDAZOLIUM CHLORIDE
  • Calimidazoline
  • Calmidazolium chloride,99%
  • Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem
  • Calmidazolium chloride (R 24571)
  • Calmidazolium chloride (Synonyms: R 24571)
  • 1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichloroph enyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-im idazol-3-ium chloride
  • Calmidazolium chlori
  • 1-(Bis(4-chlorophenyl)methyl)-3-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazol-3-ium chloride
  • CaMK,Calmidazolium,Inhibitor,R24571,Calmidazolium chloride,inhibit,R-24571,Calmodulin-dependent protein kinases,Calmodulin-dependent kinases,Autophagy
  • Calmidazolium chloride, Calmodulin inhibitor
  • Calmidazolium chloride, 10 mM in DMSO
  • 57265-65-3
  • C31H23Cl7N2O
  • Antibiotics A to Z
  • Antibiotics A-F
  • Antibiotics
  • Biochemicals and Reagents
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Calcium Antagonists
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Enzymes, Inhibitors, and Substrates
  • Other
  • Intracellular Calcium Signaling