CALMIDAZOLIUM CHLORIDE

Product Name: CALMIDAZOLIUM CHLORIDE
CAS No.: 57265-65-3
Chemical Name: CALMIDAZOLIUM CHLORIDE
Synonyms: R 24571;CALMIDAZOLIUM;COMPOUND 48/80;Calimidazoline;COMPOUND R24571;R 24571 CHLORIDE;Calmidazolium chlori;CALMIDAZOLIUM CHLORIDE;Calmidazolium chloride,99%;CALMODULIN INHIBITOR R 24571
CBNumber: CB4231628
Molecular Formula: C31H23Cl7N2O
Formula Weight: 687.69
MOL File: 57265-65-3.mol

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CALMIDAZOLIUM CHLORIDE Property

Melting point:: 172-176 °C
storage temp.: 2-8°C
solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
form: solid
color: white
Water Solubility: Soluble in dimethyl sulfoxide, ethanol. methanol, chloroform, and propylene glycol. Insoluble in water.
BRN: 6470244

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Safety

Safety Statements: 22-24/25
RIDADR: UN 2811 6.1 / PGII
WGK Germany: 3
RTECS: Gk2402500
F: 3-8-10
HS Code: 29332990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C3930
Product name: Calmidazolium chloride
Purity: solid
Packaging: 5mg
Price: $228
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2313
Product name: Compound 48/80
Packaging: 100MG
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2313
Product name: Compound 48/80
Packaging: 250MG
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2313
Product name: Compound 48/80
Packaging: 1G
Price: $661
Updated: 2024/03/01

Sigma-Aldrich

Product number: 208665
Product name: Calmidazolium Chloride
Purity: A cell-permeable calmodulin antagonist.
Packaging: 10mg
Price: $167
Updated: 2023/01/07

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CALMIDAZOLIUM CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+?transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+?influx distinct from store-operated Ca2+?entry and unaccompanied by Ca2+?store depletion, mobilizing stores and evoking a Ca2+?signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.

General Description

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.

Biological Activity

Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca 2+ -transporting ATPase with IC 50 values of 0.15 and 0.35 μ M respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

Biochem/physiol Actions

Inhibitor of calmodulin-regulated enzymes. It is also believed to directly block calcium channels in smooth muscle cells.

storage

+4°C

CALMIDAZOLIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CALMIDAZOLIUM CHLORIDE Suppliers

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57265-65-3, CALMIDAZOLIUM CHLORIDERelated Search:

1-Isopropylimidazole (S)-1-(4-Chlorophenyl)ethylamine 1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE 2,4-DICHLORO-ALPHA-METHYLBENZYL ALCOHOL (R)-1-(4-CHLOROPHENYL)ETHYLAMINE Miconazole Econazole 2,2',4,4'-TETRACHLORODIBENZYL ETHER alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 1-Ethyl-3-methylimidazolium chloride 2-AMINO-1-(4-CHLORO-PHENYL)-ETHANOL HCL CHEMBRDG-BB 9070890 1,3-DIMETHYLIMIDAZOLIUM CHLORIDE 2-HYDROXY-2-(2-CHLOROPHENYL)ETHYLAMINE HYDROCHLORIDE 1-Phenyl-2-(1-imidazolyl)ethanol CALMIDAZOLIUM CHLORIDE 2-Amino-1-(4-chlorophenyl)ethan-1-ol 4-Chloro-alpha-methylbenzylamine

CALMODULIN INHIBITOR R 24571

CALMIDAZOLIUM

CALMIDAZOLIUM CHLORIDE

COMPOUND R24571

COMPOUND 48/80

COMPOUND 48/80 TRIHYDROCHLORIDE

R 24571

R 24571 CHLORIDE

1-[bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride

R 24571, 1-[bis(4-Chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride, 1-[Bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride

1-[BIS(P-CHLOROPHENYL)METHYL]-3-[2-(2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY)PHENETHYL)]IMIDAZOLIUM CHLORIDE

1-[BIS(P-CHLOROPHENYL)METHYL]-3-[2,4-DICHLORO-BETA-(2,4 DICHLOROBENZYLOXY) PHENETHYL]-IMIDAZOLIUM CHLORIDE

[1-BIS-P-CHLOROPHENYL) METHYL]-3-[2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY) PHENYL]-IMIDAZOLIUM CHLORIDE

1-[BIS-(4-CHLOROPHENYL)METHYL]-3-[2-(2,4-DICHLOROPHENYL)-2-[(2,4-DICHLOROPHENYL)METHOXY]-ETHYL]-1H-IMIDAZOLIUM CHLORIDE

1-[BIS(4-CHLOROPHENYL)METHYL]-3-[2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY)PHENETHYL]IMIDAZOLIUM CHLORIDE

Calimidazoline

Calmidazolium chloride,99%

Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem

Calmidazolium chloride (R 24571)

Calmidazolium chloride (Synonyms: R 24571)

1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichloroph enyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-im idazol-3-ium chloride

Calmidazolium chlori

1-(Bis(4-chlorophenyl)methyl)-3-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazol-3-ium chloride

CaMK,Calmidazolium,Inhibitor,R24571,Calmidazolium chloride,inhibit,R-24571,Calmodulin-dependent protein kinases,Calmodulin-dependent kinases,Autophagy

57265-65-3

C31H23Cl7N2O

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