4,4,5,5,5-Pentafluoro-1-pentanol

ChemicalBook > CAS DataBase List > 4,4,5,5,5-Pentafluoro-1-pentanol

4,4,5,5,5-Pentafluoro-1-pentanol

Product Name: 4,4,5,5,5-Pentafluoro-1-pentanol
CAS No.: 148043-73-6
Chemical Name: 4,4,5,5,5-Pentafluoro-1-pentanol
Synonyms: 4,4,5,5,5-PENTAFLUOROPENTAN-1-OL;Pentafluoropentanol;4,4,5,5,5-PENTAFLUOROPENTANOL;Fulvestrant Impurity 31;Fulvestrant InterMediates;Fulvestrant intermediate C;1,1,5,5,5-pentafluoro-1-pentanol;4,4,5,5,5-PENTAFLUORO-1-PENTANOL;1-Pentanol,4,4,5,5,5-pentafluoro-;4,4,5,5,5-Pentafluoropentan-1-ol96%
CBNumber: CB4232519
Molecular Formula: C5H7F5O
Formula Weight: 178.1
MOL File: 148043-73-6.mol

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4,4,5,5,5-Pentafluoro-1-pentanol Property

Boiling point:: 62-64 °C35 mm Hg(lit.)
Density: 1.35 g/mL at 25 °C(lit.)
vapor pressure: 1.1-155.2hPa at 25-80.3℃
refractive index: n20/D 1.33(lit.)
Flash point:: 145 °F
storage temp.: 2-8°C
solubility: Chloroform
pka: 14.77±0.10(Predicted)
form: Liquid
color: Clear colorless
InChI: InChI=1S/C5H7F5O/c6-4(7,2-1-3-11)5(8,9)10/h11H,1-3H2
InChIKey: QROUUECTKRZFHF-UHFFFAOYSA-N
SMILES: C(O)CCC(F)(F)C(F)(F)F
LogP: 1.59 at 25℃ and pH7
CAS DataBase Reference: 148043-73-6(CAS DataBase Reference)
EPA Substance Registry System: 3-(Perfluoroethyl)propanol (148043-73-6)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36-36/37/38
Safety Statements: 26-36
RIDADR: 1993
WGK Germany: 2
Hazard Note: Irritant
HazardClass: FLAMMABLE
HS Code: 29055900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 541133
Product name: 4,4,5,5,5-Pentafluoro-1-pentanol
Purity: 95%
Packaging: 5g
Price: $25.52
Updated: 2024/03/01

Sigma-Aldrich

Product number: 541133
Product name: 4,4,5,5,5-Pentafluoro-1-pentanol
Purity: 95%
Packaging: 25g
Price: $261
Updated: 2024/03/01

TCI Chemical

Product number: P1342
Product name: 4,4,5,5,5-Pentafluoro-1-pentanol
Purity: >93.0%(GC)
Packaging: 5g
Price: $49
Updated: 2024/03/01

TCI Chemical

Product number: P1342
Product name: 4,4,5,5,5-Pentafluoro-1-pentanol
Purity: >93.0%(GC)
Packaging: 25g
Price: $173
Updated: 2024/03/01

Alfa Aesar

Product number: B21512
Product name: 4,4,5,5,5-Pentafluoropentanol, 94%
Packaging: 2g
Price: $32.65
Updated: 2024/03/01

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4,4,5,5,5-Pentafluoro-1-pentanol Chemical Properties,Usage,Production

Description

4,4,5,5,5-Pentafluoro-1-pentanol (PFP; Pentafluoropentanol) is an essential building block primarily used in the commercial manufacture of the API. It is typically activated with a sulfonate leaving group and displaced selectively by the sulfur atom in 9-mercapto-1-nonanol to make 9-[(4,4,5,5,5-pentafluoropentyl)-thio]-1-nonanol (FVS). FVS is subsequently converted into a bromide and coupled with the steroid portion to make fulvestrant. First approved by the FDA in 2002, fulvestrant is a medication used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression.

Chemical Properties

Colorless to yellow liquid

Uses

4,4,5,5,5-Pentafluoro-1-pentanol may be used in the preparation of chlorine-capped telechelic poly(methyl methacrylate)s.

Uses

4,4,5,5,5-Pentafluoro-1-pentanol (Pentafluoropentanol) is an intermediate in preparing pentafluoropentane-1-thiol: a vital chain of anti-breast cancer agents.

General Description

4,4,5,5,5-Pentafluoro-1-pentanol, also known as pentafluoropentanol, is a perfluorous solvent.

Synthesis

Pentafluoroiodoethane could used as a starting material to synthesize 4,4,5,5,5-Pentafluoro-1-pentanol. Specific steps are as follows: under an inert gas atmosphere, iron acetylacetonate, 6,6'-dimethyl-2,2'-bipyridine, and 1,2-dichloroethane were added to the reactor, reacted at RT for 0.5 h; added allyl alcohol, cesium carbonate, pentafluoroiodoethane successively, triisopropylsilane, warmed up to 80 ℃ and reacted for 24 h. Sampling and detection confirmed that the reaction of allyl alcohol was complete, stopped the reaction, and cooled to room temperature. The excess pentafluoroiodoethane was recovered, nitrogen was introduced into the system, hydrochloric acid was added to quench the reaction, washed, separated to obtain an organic phase, distilled to remove the solvent, and rectified to obtain 4,4,5,5,5-pentafluoro Amyl alcohol. Yield: 90.4%.

4,4,5,5,5-Pentafluoro-1-pentanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4,4,5,5,5-Pentafluoro-1-pentanol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 4,4,5,5,5-Pentafluoro-1-pentanol 148043-73-6
Price: US $65.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-06-07

Henan Aochuang Chemical Co.,Ltd.

Product: 4,4,5,5,5-Pentafluoro-1-pentanol 148043-73-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4,4,5,5,5-Pentafluoro-1-pentanol 148043-73-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

148043-73-6, 4,4,5,5,5-Pentafluoro-1-pentanolRelated Search:

PERFLUOROPENTANOIC ACID 4,4,5,5,5-Pentafluoro-1-pentanethiol ETHYL PENTAFLUOROPROPIONYLACETATE 4,4,5,5,5-Pentafluoro-1-pentanol Fenipentol ISOAMYL ALCOHOL 1-Pentanol ALLYL PERFLUOROPENTANOATE 2,3,3,3-TETRAFLUORO-2-(PERFLUOROPENTOXY)PROPAN-1-OL (NONAFLUORO-N-BUTYL)EPOXIDE 1H,1H-HEPTAFLUOROBUTYL EPOXIDE PERFLUORO-2-TRIFLUOROMETHYL-4-OXANONANE ETHYL PERFLUOROPENTANOATE 1H,1H-PERFLUOROPENTAN-1-OL METHYL NONAFLUOROVALERATE METHYL PENTAFLUOROPROPIONYLACETATE 2,2,3,3,4,4,5,5,5-NONAFLUOROPENTYL 2,5,7-TRINITRO-9-OXO-9H-FLUORENE-4-CARBOXYLATE METHYL-3,3-DIMETHOXY-3-(PERFLUOROBUTYL)PROPANOATE

4,4,5,5,5-PENTAFLUOROPENTAN-1-OL

4,4,5,5,5-PENTAFLUOROPENTANOL

4,4,5,5,5-PENTAFLUORO-1-PENTANOL

Pentafluoropentanol

4,4,5,5,5-Pentafluoropentan-1-ol 96%

4,4,5,5,5-Pentafluoropentan-1-ol96%

Fulvestrant intermediate C

Fulvestrant Impurity 31

1,1,5,5,5-pentafluoro-1-pentanol

4,4,5,5,5-pentafluoropentyl alcohol

4,4,5,5,5-Pentafluoro-1-pentanol,95%

Fulvestrant InterMediates

1-Pentanol,4,4,5,5,5-pentafluoro-

4,4,5,5,5-Pentafluoro-1-pentanol 95%

4,4,5,5,5-Pentafluoro-1-pentanol ,97%

4,4,5,5,5-Pentafluoropentan-1-ol, tech

5-Hydroxy-1,1,1,2,2-pentafluoropentane, 3-(Perfluoroethyl)propan-1-ol

4,4,5,5,5-Pentafluoro-1-pentanol&gt

4,4,5,5,5-Pentafluoro-1-pentanol(For export only)

148043-73-6

148-043-6

C5H7F5O

C2F5CH2CH2CH2OH

CF3CF2CH23OH

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