Fluocinonide

ChemicalBook > CAS DataBase List > Fluocinonide

Product Name: Fluocinonide
CAS No.: 356-12-7
Chemical Name: Fluocinonide
Synonyms: fluocinolide;Vanos;Fluoxetine acetate;Fluocinonide Acetonide;Fluocinolone Acetonide EP Impurity M;Lidex;Lonide;topsym;Topsyn;lidexe
CBNumber: CB4240194
Molecular Formula: C26H32F2O7
Formula Weight: 494.52
MOL File: 356-12-7.mol

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Fluocinonide Property

Melting point:: 309 °C
alpha: D +83° (chloroform)
Boiling point:: 235°C (rough estimate)
Density: 1.2001 (estimate)
storage temp.: 2-8°C
solubility: DMSO: ≥19mg/mL
form: powder
pka: 12.77±0.70(Predicted)
color: white to tan
optical activity: [α]/D +75 to +90°, c = 1 in dichloromethane
Water Solubility: 0.53mg/L(25 ºC)
InChIKey: WJOHZNCJWYWUJD-IUGZLZTKSA-N

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Safety

Hazard Codes: T+
Risk Statements: 28-63
Safety Statements: 22-25-28-36/37/39-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: TU3831000
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 2937220000
Toxicity: guinea pig,LD50,subcutaneous,> 3170mg/kg (3170mg/kg),Drugs in Japan Vol. 6, Pg. 694, 1982.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0099
Product name: Fluocinonide
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP489
Product name: Fluocinonide
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 23803
Product name: Fluocinonide
Purity: ≥98%
Packaging: 5mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 23803
Product name: Fluocinonide
Purity: ≥98%
Packaging: 10mg
Price: $72
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0099
Product name: Fluocinonide
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $527
Updated: 2024/03/01

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Fluocinonide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Topsyn ,Recordati,Italy,1970

Uses

Glucocorticoid; anti-inflammatory.

Uses

Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.

Indications

Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.

Definition

ChEBI: Fluocinonide is an organic molecular entity.

Manufacturing Process

To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room temperature for 3 hours. During this period the crystals gradually dissolve and the clear solution is neutralized with dilute bicarbonate and the acetone removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95% alcohol to give the pure acetonide.
A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine and 1 ml of acetic anhydride is allowed to stand at room temperature for 18 hours. Removal of the reagents in vacuo gives a crystalline residue which after crystallization from acetone-hexane gives the pure 16α,17α- isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described in US Patent 3,197,469.

brand name

Lidex (Medicis); Vanos (Medicis).

Therapeutic Function

Antiinflammatory, Glucocorticoid

Biochem/physiol Actions

Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.

Fluocinonide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fluocinonide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Fluocinonide 356-12-7
Price: US $0.00/g/Bag
Min. Order: 10g
Purity: 97.0%~103.0%; BP2015
Supply Ability: 70kg/month
Release date: 2021-06-11

Hebei Weibang Biotechnology Co., Ltd

Product: Fluocinonide 356-12-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-06

Hebei Chuanghai Biotechnology Co,.LTD

Product: Fluocinonide 356-12-7
Price: US $40.70/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-09

356-12-7, FluocinonideRelated Search:

fluocinolone16,17-acetonide Triamcinolone acetonide Fluocinolone Acetonide-21-carboxylic Acid 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate 21-Acetyl-6β-fluorotriamcinolone Acetonide 9beta,11beta-epoxy-6alpha-fluoro-21-hydroxy-16alpha,17-(isopropylidene)dioxypregna-1,4-diene-3,20-dione Fluocoutolone Hexanoate 6-alpha-fluoro-21-hydroxy-16-alpha,17-alpha-isopropylidenedioxypregn-4-ene-3,20-dione (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid Fluocinolone Acetonide-21-aldehyde 6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate) Fluocinolone Acetonide Impurity 4 9beta,11beta-epoxy-6alpha-fluoro-21-hydroxy-16alpha,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione 21-acetate FLURANDRENOLONE ACETATE Fluocinolone (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-21-Methoxy-16,17-[(1-Methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione Fluocinolone Acetonide Impurity 2 9a-Fluoro-11, 6a, 17a, 21-Tetrahydroxy-Pregna-4-ene-3, 20-Dione

Cortalar

Gelisyn

Lidemol

Fluocinonide (100 mg)

Fluocinonide(Vanos)

(6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Flucetonide

Vanos

Fluocinonide Solution, 100ppm

Lonide

1,4-PREGNADIEN-6-ALPHA, 9-ALPHA-DIFLUORO-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE 21-ACETATE

FLUOCINOLONE ACETONIDE 21-ACETATE

FLUOCINOMIDE

FLUOCINONIDE

FLUOCINONIDE ACETONIDE 21-ACETATE

droxy-,cyclic17-acetalwithacetone,21-acetate

pregna-1,4-diene-3,20-dione,6-alpha,9-difluoro-11-beta,16-alpha,17,21-tetrahy

topsym

Fluocinoide acetonide

FLUOCINONIDE,MICRONIZED,USP

Biscosal

Lidex

NSC 101791

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-

Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate (7CI, 8CI)

Straderm

Topsymin

Topsyn

Topsyne

pregna-1,4-diene-3,20-dione, 6-alpha, 9-difluoro-11-beta,16-alpha,17,21-tetrahy droxy-, cyclic 17-acetal with acetone, 21-acetate flucinar fluocinolide fluocinolide acetate fluocinolone acetonide 21-acetate fluocinolone acetonide acetate fluocinonide lidex e Fluocinonide acetate 21-Acatyloxy-6,9-diflulro-11-hydroxy-16,17-[(1-methyl-ethylidene)bis(oxy)]pregna-1,4-di-ene-3,20-dione

Fluocinonide, Micronized

Fluocinolone Acetonide EP Impurity M

flucinar

fluocinolide

fluocinolideacetate

fluocinoloneacetonideacetate

Fluocinonideacetate

lidexe

metosyn

2-chloroethoxy(diphenyl)phosphine

Fluocinonide Acetonide

Fluocinonide RS

Fluocinolone Acetonide Impurity 13 (Fluocinolone Acetonide EP Impurity M）(Fluocinonide)

Fluorocarbon acetate

Fluoxetine acetate

Fluocinonide USP/EP/BP

FluocinonideQ: What is Fluocinonide Q: What is the CAS Number of Fluocinonide Q: What is the storage condition of Fluocinonide Q: What are the applications of Fluocinonide

6α,9-Difluoro-11β-hydroxy-16α,17-(1-methylethylidenedioxy)-3,20-dioxopregna-1,4-dien-21-yl Acetate

Fluocinonide (1276001)

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-

Fluocinolone Acetonide Impurity M

1, 4-PREGNADIEN-6α, 9α-DIFLUORO-11β, 16α, 17, 21-TETROL-3, 20-DIONE 16, 17-ACETONIDE 21-ACETATE

Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6a,11b,16a)-

C13729000 Fluocinonide

356-12-7

C26H32F2P7

FA - FL

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