ChemicalBook > CAS DataBase List > Fluocinonide

Fluocinonide

Product Name
Fluocinonide
CAS No.
356-12-7
Chemical Name
Fluocinonide
Synonyms
fluocinolide;Vanos;Fluoxetine acetate;Fluocinonide Acetonide;Fluocinolone Acetonide EP Impurity M;Lidex;Lonide;topsym;Topsyn;lidexe
CBNumber
CB4240194
Molecular Formula
C26H32F2O7
Formula Weight
494.52
MOL File
356-12-7.mol
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Fluocinonide Property

Melting point:
309 °C
alpha 
D +83° (chloroform)
Boiling point:
235°C (rough estimate)
Density 
1.2001 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: ≥19mg/mL
form 
powder
pka
12.77±0.70(Predicted)
color 
white to tan
optical activity
[α]/D +75 to +90°, c = 1 in dichloromethane
Water Solubility 
0.53mg/L(25 ºC)
InChIKey
WJOHZNCJWYWUJD-IUGZLZTKSA-N
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Safety

Hazard Codes 
T+
Risk Statements 
28-63
Safety Statements 
22-25-28-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
TU3831000
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
2937220000
Toxicity
guinea pig,LD50,subcutaneous,> 3170mg/kg (3170mg/kg),Drugs in Japan Vol. 6, Pg. 694, 1982.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0099
Product name
Fluocinonide
Purity
≥98% (HPLC)
Packaging
10mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
BP489
Product name
Fluocinonide
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$257
Updated
2024/03/01
Cayman Chemical
Product number
23803
Product name
Fluocinonide
Purity
≥98%
Packaging
5mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
23803
Product name
Fluocinonide
Purity
≥98%
Packaging
10mg
Price
$72
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0099
Product name
Fluocinonide
Purity
≥98% (HPLC)
Packaging
50mg
Price
$527
Updated
2024/03/01
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Fluocinonide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Topsyn ,Recordati,Italy,1970

Uses

Glucocorticoid; anti-inflammatory.

Uses

Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.

Indications

Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.

Definition

ChEBI: Fluocinonide is an organic molecular entity.

Manufacturing Process

To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room temperature for 3 hours. During this period the crystals gradually dissolve and the clear solution is neutralized with dilute bicarbonate and the acetone removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95% alcohol to give the pure acetonide.
A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine and 1 ml of acetic anhydride is allowed to stand at room temperature for 18 hours. Removal of the reagents in vacuo gives a crystalline residue which after crystallization from acetone-hexane gives the pure 16α,17α- isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described in US Patent 3,197,469.

brand name

Lidex (Medicis); Vanos (Medicis).

Therapeutic Function

Antiinflammatory, Glucocorticoid

Biochem/physiol Actions

Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.

Fluocinonide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fluocinonide manufacturers

Henan Tengmao Chemical Technology Co. LTD
Product
Fluocinonide 356-12-7
Price
US $110.00-90.00/kilogram
Min. Order
1kilogram
Purity
99%
Supply Ability
10 tons/per week
Release date
2024-02-28
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Fluocinonide 356-12-7
Price
US $0.00/g/Bag
Min. Order
10g
Purity
97.0%~103.0%; BP2015
Supply Ability
70kg/month
Release date
2021-06-11
Hebei Mojin Biotechnology Co., Ltd
Product
Fluocinonide 356-12-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-06

356-12-7, FluocinonideRelated Search:

fluocinolone16,17-acetonide Triamcinolone acetonide Fluocinolone Acetonide-21-carboxylic Acid 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate 21-Acetyl-6β-fluorotriamcinolone Acetonide 9beta,11beta-epoxy-6alpha-fluoro-21-hydroxy-16alpha,17-(isopropylidene)dioxypregna-1,4-diene-3,20-dione Fluocoutolone Hexanoate 6-alpha-fluoro-21-hydroxy-16-alpha,17-alpha-isopropylidenedioxypregn-4-ene-3,20-dione (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid Fluocinolone Acetonide-21-aldehyde 6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate) Fluocinolone Acetonide Impurity 4 9beta,11beta-epoxy-6alpha-fluoro-21-hydroxy-16alpha,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione 21-acetate FLURANDRENOLONE ACETATE Fluocinolone (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-21-Methoxy-16,17-[(1-Methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione Fluocinolone Acetonide Impurity 2 9a-Fluoro-11, 6a, 17a, 21-Tetrahydroxy-Pregna-4-ene-3, 20-Dione

  • Cortalar
  • Gelisyn
  • Lidemol
  • Fluocinonide (100 mg)
  • Fluocinonide(Vanos)
  • (6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
  • Flucetonide
  • Vanos
  • Fluocinonide Solution, 100ppm
  • Lonide
  • 1,4-PREGNADIEN-6-ALPHA, 9-ALPHA-DIFLUORO-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE 21-ACETATE
  • FLUOCINOLONE ACETONIDE 21-ACETATE
  • FLUOCINOMIDE
  • FLUOCINONIDE
  • FLUOCINONIDE ACETONIDE 21-ACETATE
  • droxy-,cyclic17-acetalwithacetone,21-acetate
  • pregna-1,4-diene-3,20-dione,6-alpha,9-difluoro-11-beta,16-alpha,17,21-tetrahy
  • topsym
  • Fluocinoide acetonide
  • FLUOCINONIDE,MICRONIZED,USP
  • Biscosal
  • Lidex
  • NSC 101791
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-
  • Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate (7CI, 8CI)
  • Straderm
  • Topsymin
  • Topsyn
  • Topsyne
  • pregna-1,4-diene-3,20-dione, 6-alpha, 9-difluoro-11-beta,16-alpha,17,21-tetrahy droxy-, cyclic 17-acetal with acetone, 21-acetate flucinar fluocinolide fluocinolide acetate fluocinolone acetonide 21-acetate fluocinolone acetonide acetate fluocinonide lidex e Fluocinonide acetate 21-Acatyloxy-6,9-diflulro-11-hydroxy-16,17-[(1-methyl-ethylidene)bis(oxy)]pregna-1,4-di-ene-3,20-dione
  • Fluocinonide, Micronized
  • Fluocinolone Acetonide EP Impurity M
  • flucinar
  • fluocinolide
  • fluocinolideacetate
  • fluocinoloneacetonideacetate
  • Fluocinonideacetate
  • lidexe
  • metosyn
  • 2-chloroethoxy(diphenyl)phosphine
  • Fluocinonide Acetonide
  • Fluocinonide RS
  • Fluocinolone Acetonide Impurity 13 (Fluocinolone Acetonide EP Impurity M）(Fluocinonide)
  • Fluorocarbon acetate
  • Fluoxetine acetate
  • Fluocinonide USP/EP/BP
  • FluocinonideQ: What is Fluocinonide Q: What is the CAS Number of Fluocinonide Q: What is the storage condition of Fluocinonide Q: What are the applications of Fluocinonide
  • 6α,9-Difluoro-11β-hydroxy-16α,17-(1-methylethylidenedioxy)-3,20-dioxopregna-1,4-dien-21-yl Acetate
  • Fluocinonide (1276001)
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-
  • Fluocinolone Acetonide Impurity M
  • 1, 4-PREGNADIEN-6α, 9α-DIFLUORO-11β, 16α, 17, 21-TETROL-3, 20-DIONE 16, 17-ACETONIDE 21-ACETATE
  • Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6a,11b,16a)-
  • 356-12-7
  • C26H32F2P7
  • FA - FL
  • Analytical Chromatography Product Catalog
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