(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one

ChemicalBook > CAS DataBase List > (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one

Product Name: (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
CAS No.: 126860-83-1
Chemical Name: (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
Synonyms: MC-1046;24-carbonyl-Calcipotriol;IMpurity A of Calcipotriol;Calcipotriol EP Impurity A: Ketone analog;Calcipotriol Impurity 1(Calcipotriol EP Impurity A);(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one;(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one;(5Z,7E,22E)-24-Cyclopropyl-1α,3β-dihydroxy-9,10-secochola-5,7,10 (19),22-tetraen-24-one;(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one;(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one (90%)
CBNumber: CB42414777
Molecular Formula: C27H38O3
Formula Weight: 410.59
MOL File: 126860-83-1.mol

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(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Property

Boiling point:: 584.2±50.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility: Soluble in DMSO
form: Powder
pka: 14.43±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C988310
Product name: (1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one(90%)
Packaging: 0.25mg
Price: $305
Updated: 2021/12/16

ChemScene

Product number: CS-1162
Product name: MC1046
Packaging: 1mg
Price: $500
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 68944
Product name: (1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one(90%)
Packaging: 0.25mg
Price: $750
Updated: 2021/12/16

ApexBio Technology

Product number: A3588
Product name: MC1046
Packaging: 1mg
Price: $1339
Updated: 2021/12/16

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(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Chemical Properties,Usage,Production

Uses

MC 1046 is a vitamin D3 analogue with similar effects. Impurity of Calcipotriol (C144200), an antipsoriatic.

Biological Activity

mc 903 has been found to be a potent inducer of cell differentiation and to inhibit proliferation and dna-synthesis of cells possessing the receptor for 1,25(oh)2d3. mc 1046 is the metabolite of calcipotrioi (mc 903), which is a novel analogue of the physiologically active metabolite of vitamin d3.

in vitro

the biological effects on the u937 cells of the two major metabolites of mc 903 (mc 1046 and mc 1080) were investigated. results showed that the metabolites had effects that were more than 100 times weaker than those of the parent compound [1].

in vivo

mc 903 is a novel analogue of the physiologically active metabolite of 1,25(oh)2d3. unlike the similar effects on cell proliferation and cell differentiation in vitro, mc 903 has 100-200 times less effect on calcium metabolism in vivo. moreover, rat study indicats that the effect of mc 903 on proliferative disorders, its fast elimination and the formation of inactive metabolites makes mc 903 suitable for topical treatment of psoriasis [1].

References

[1] kissmeyer am, binderup l. calcipotriol (mc 903): pharmacokinetics in rats and biological activities of metabolites. a comparative study with 1,25(oh)2d3. biochem pharmacol. 1991;41(11):1601-6.

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: MC 1046 126860-83-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons
Release date: 2023-01-31

Career Henan Chemical Co

Product: (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one 126860-83-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 200kg
Release date: 2020-03-05

126860-83-1, (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-oneRelated Search:

(5E)-Calcipotriene Calcipotriene 24R-Calcipotriol (1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldiMethylsilyl)oxy)-2-Methylenecyclohexylidene)ethylidene)-7a-Methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one

MC-1046

IMpurity A of Calcipotriol

(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one

(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one (90%)

(1alpha,3beta,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-secochola-5,7,10(19),22-tetraen-24-one

Calcipotriol EP Impurity A: Ketone analog

Calcipotriol Impurity 1(Calcipotriol EP Impurity A)

Calcipotriol EP Impurity A/(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one

2-Penten-1-one, 1-cyclopropyl-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-, (2E,4R)-

(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one

(5Z,7E,22E)-24-Cyclopropyl-1α,3β-dihydroxy-9,10-secochola-5,7,10 (19),22-tetraen-24-one

24-carbonyl-Calcipotriol

Calcipotriol EP Impurity A/(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one

126860-83-1

Matabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals