ChemicalBook > CAS DataBase List > (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
- Product Name
- (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
- CAS No.
- 126860-83-1
- Chemical Name
- (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one
- Synonyms
- MC-1046;24-carbonyl-Calcipotriol;IMpurity A of Calcipotriol;Calcipotriol EP Impurity A: Ketone analog;Calcipotriol Impurity 1(Calcipotriol EP Impurity A);(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one;(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one;(5Z,7E,22E)-24-Cyclopropyl-1α,3β-dihydroxy-9,10-secochola-5,7,10 (19),22-tetraen-24-one;(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one;(1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one (90%)
- CBNumber
- CB42414777
- Molecular Formula
- C27H38O3
- Formula Weight
- 410.59
- MOL File
- 126860-83-1.mol
More
Less
(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Property
- Boiling point:
- 584.2±50.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 14.43±0.40(Predicted)
- color
- Light yellow to yellow
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- C988310
- Product name
- (1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one(90%)
- Packaging
- 0.25mg
- Price
- $305
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-1162
- Product name
- MC1046
- Packaging
- 1mg
- Price
- $500
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 68944
- Product name
- (1α,3β,5Z,7E,22E)-24-Cyclopropyl-1,3-dihydroxy-9,10-Secochola-5,7,10(19),22-tetraen-24-one(90%)
- Packaging
- 0.25mg
- Price
- $750
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3588
- Product name
- MC1046
- Packaging
- 1mg
- Price
- $1339
- Updated
- 2021/12/16
More
Less
(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Chemical Properties,Usage,Production
Uses
MC 1046 is a vitamin D3 analogue with similar effects. Impurity of Calcipotriol (C144200), an antipsoriatic.
Biological Activity
mc 903 has been found to be a potent inducer of cell differentiation and to inhibit proliferation and dna-synthesis of cells possessing the receptor for 1,25(oh)2d3. mc 1046 is the metabolite of calcipotrioi (mc 903), which is a novel analogue of the physiologically active metabolite of vitamin d3.
in vitro
the biological effects on the u937 cells of the two major metabolites of mc 903 (mc 1046 and mc 1080) were investigated. results showed that the metabolites had effects that were more than 100 times weaker than those of the parent compound [1].
in vivo
mc 903 is a novel analogue of the physiologically active metabolite of 1,25(oh)2d3. unlike the similar effects on cell proliferation and cell differentiation in vitro, mc 903 has 100-200 times less effect on calcium metabolism in vivo. moreover, rat study indicats that the effect of mc 903 on proliferative disorders, its fast elimination and the formation of inactive metabolites makes mc 903 suitable for topical treatment of psoriasis [1].
References
[1] kissmeyer am, binderup l. calcipotriol (mc 903): pharmacokinetics in rats and biological activities of metabolites. a comparative study with 1,25(oh)2d3. biochem pharmacol. 1991;41(11):1601-6.
(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
(5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one Suppliers
- Tel
- 18096409024
- sales02@foreversyn.com
- Country
- China
- ProdList
- 1917
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
- Country
- China
- ProdList
- 8065
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18043
- Advantage
- 56
- Tel
- 021-50215258
- Fax
- 021-50215756
- market@hypharma.com
- Country
- China
- ProdList
- 321
- Advantage
- 58
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- 025-66023220 0086-15250997978
- Fax
- 025-58362220
- 1511893459@qq.com
- Country
- China
- ProdList
- 7850
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 4009
- Advantage
- 58
- Tel
- +86-0371-55023472 +86-13663848272
- Fax
- 0371-55023472
- 2584787837@qq.com
- Country
- China
- ProdList
- 242
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 56902
- Advantage
- 58
- Tel
- +86-027-59207850
- Fax
- 86-27-59524646
- info@fortunachem.com
- Country
- China
- ProdList
- 5986
- Advantage
- 58
- Tel
- 2710913286@.com
- 1513643261@qq.com
- Country
- China
- ProdList
- 14246
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11217
- Advantage
- 58
- Tel
- 0755-61348847 17820674378
- Fax
- 0755-21016893
- 2682116078@qq.com
- Country
- China
- ProdList
- 7843
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29815
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 029-81145920 13259709322
- Fax
- 029-88380327
- 1027@dideu.com
- Country
- China
- ProdList
- 10009
- Advantage
- 58
- Tel
- 400-820-6829
- sales@mitachieve.com
- Country
- China
- ProdList
- 8860
- Advantage
- 58
- Tel
- 0531-88723173 18596073690
- 1047208234@qq.com
- Country
- China
- ProdList
- 4328
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 020-36607679 13502246435
- sales@dmstandards.com
- Country
- China
- ProdList
- 10945
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 0757-85921206 18520245316
- 2329783215@qq.com
- Country
- China
- ProdList
- 12661
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40037
- Advantage
- 58
- Tel
- 2122619822
- czbjpharma@126.com
- Country
- China
- ProdList
- 18478
- Advantage
- 58
- Tel
- 020-81960175-877 18933936954
- tianwen.zhan@cato-chem.com
- Country
- China
- ProdList
- 7734
- Advantage
- 58
- Tel
- 13810165869
- xiaodongbai@haotianpharm.com
- Country
- China
- ProdList
- 195
- Advantage
- 58
- Tel
- 13417589054 13417589054
- trendseenbio@gmail.com
- Country
- China
- ProdList
- 9470
- Advantage
- 58
- Tel
- 15671363360
- 494267389@qq.com
- Country
- China
- ProdList
- 3133
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 19850211281
- qiann@gbw-china.com
- Country
- China
- ProdList
- 1980
- Advantage
- 58
- Tel
- 021-54580889 18321124657
- Fax
- 021-54580889
- 731997554@qq.com
- Country
- China
- ProdList
- 10608
- Advantage
- 58
- Tel
- 13070690626
- admin@mopaikeji.com
- Country
- China
- ProdList
- 10756
- Advantage
- 58
- Tel
- 18162595016; 18162595016
- 3287908757@qq.com
- Country
- China
- ProdList
- 9122
- Advantage
- 58
- Tel
- 18616537568
- hanfangpharma@126.com
- Country
- China
- ProdList
- 30961
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9272
- Advantage
- 58
- Tel
- 027-88188016 18717196322
- 1764683941@qq.com
- Country
- China
- ProdList
- 5672
- Advantage
- 58
- Tel
- 13342851930
- 3008394369@qq.com
- Country
- China
- ProdList
- 15684
- Advantage
- 58
- Tel
- 13417589054
- trendseenbio@gmail.com
- Country
- China
- ProdList
- 11681
- Advantage
- 58
- Tel
- +86-0533-2185556 +8617865335152
- Mandy@hangyubiotech.com
- Country
- China
- ProdList
- 10986
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6502
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 102
- Advantage
- 58
- Tel
- --
- Fax
- --
- WHIGA22@126.COM
- Country
- CHINA
- ProdList
- 6748
- Advantage
- 58
More
Less
View Lastest Price from (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- MC 1046 126860-83-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons
- Release date
- 2023-01-31
Career Henan Chemical Co
- Product
- (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-one 126860-83-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 200kg
- Release date
- 2020-03-05
126860-83-1, (5Z,7E,22E)-9,10-Seco-26,27-cyclo-1α,3β-dihydroxycholesta-5,7,10(19),22-tetren-24-oneRelated Search:
(5E)-Calcipotriene
Calcipotriene
24R-Calcipotriol
(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldiMethylsilyl)oxy)-2-Methylenecyclohexylidene)ethylidene)-7a-Methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol