Dithiooxamide Property

Melting point:

≥300 °C(lit.)

Boiling point:

287.76°C (estimate)

Density 

1.353 (estimate)

refractive index 

1.5300 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

ethanol: soluble40mg/10 mL, clear, red

pka

pK1:10.89 (25°C)

form 

solid

color 

Orange to Amber to Dark red

Water Solubility 

Soluble in alcohols. Slightly soluble in water. Insoluble in ether

Merck 

14,8279

BRN 

605577

Stability:

Stable.

InChIKey

OAEGRYMCJYIXQT-UHFFFAOYSA-N

CAS DataBase Reference

79-40-3(CAS DataBase Reference)

NIST Chemistry Reference

Ethanedithioamide(79-40-3)

EPA Substance Registry System

Ethanedithioamide (79-40-3)

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

36/37

WGK Germany 

3

RTECS 

RP1575000

TSCA 

Yes

HS Code 

29309070

Hazardous Substances Data

79-40-3(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 500 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Dithiooxamide Chemical Properties,Usage,Production

Chemical Properties

orange to brown crystalline powder

Uses

Rubeanic acid may be used for the quantitative precipitation of copper, nickel and cobalt. The copper complex is dark green, the cobalt brownish-red and the nickel violet. All these complexes are chelates of outstanding stability, and this, together with their vivid Colours, affords the reaction great analytical sensitivity.
The copper complex is the most stable of the three; it can be precipitated even from mild mineral acidic solution, while precipitation of the corresponding cobalt and nickel complexes requires buffered media. On the other hand, palladium, platinum and silver react with rubeanic acid to give precipitates in strongly acidic solution. It should be mentioned, however, that in the case of platinum and some other metals (zinc, cadmium, silver, lead, mercury) the product is the corresponding sulfide rather than the rubeanate complex.
Rubeanic acid reacts with ruthenium to give a blue water-soluble complex ion, which is utilized for the spectrophotometric determination of ruthenium. Rubeanic acid has similarly been used for the spectrophotometric determination of osmium.
It has also proved suitable for the solvent extraction separation and determination of thallium. It has been found that thallium exists in the organic phase in the form of a complex of composition Tl/dto/Hdto, where dto represents the rubeanate anion with one negative charge.

Uses

Dithiooxamide acts as a chelating agent and used in the determination of copper(II), nickel(II) and cobalt(II). It is used as a building block in the synthesis of cyclen. It is involved in the preparation of thiazolothiazole-linked porous organic polymers and N,N'-disubstituted dithiooxamides. It is also employed as a modifier to prepare the modified glassy carbon electrode which is used to investigate the electrochemical properties of quercetin, an important flavonoid derivative. Further, it is involved in the preparation of chelating resin with formaldehyde, which finds application in separation and concentration of silver ions.

Uses

As a reagent for copper, cobalt, and nickel. As a stabilizer of ascorbic acid solutions: Smoczkiewicz, Grochmalicka, Nature 192, 16 (1961).

General Description

Dithiooxamide is reported to form complexes with Ni(II).

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits very toxic fumes of NOx and SOx

Purification Methods

Crystallise dithiooxamide from EtOH and sublime it at high vacuum. [Beilstein 2 IV 1871.]