5-Amino-1,6-naphthyridine
- Product Name
- 5-Amino-1,6-naphthyridine
- CAS No.
- 55570-60-0
- Chemical Name
- 5-Amino-1,6-naphthyridine
- Synonyms
- 1,6phthyridin-5-ylamine;1,6-Naphthyridin-5-aMine;5-Amino-1,6-naphthyridine;[1,6]Naphthyridin-5-ylaMine;1,6-Naphthyridin-5-amine (9CI, ACI);1,6-Naphthyridin-5-Amine 1,6naphthyridin5amine
- CBNumber
- CB42430553
- Molecular Formula
- C8H7N3
- Formula Weight
- 145.16
- MOL File
- 55570-60-0.mol
5-Amino-1,6-naphthyridine Property
- Boiling point:
- 343.3±27.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 5.54±0.30(Predicted)
- Appearance
- Yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- N373535
- Product name
- 1,6-Naphthyridin-5-amine
- Packaging
- 200mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- CHM0380490
- Product name
- 1,6-NAPHTHYRIDIN-5-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.55
- Updated
- 2021/12/16
- Product number
- 8112AB
- Product name
- 1,6-Naphthyridin-5-amine
- Packaging
- 1g
- Price
- $536
- Updated
- 2021/12/16
- Product number
- 145174
- Product name
- 1,6-Naphthyridin-5-amine
- Purity
- 95%
- Packaging
- 5g
- Price
- $2960
- Updated
- 2021/12/16
- Product number
- 8112AB
- Product name
- 1,6-Naphthyridin-5-amine
- Packaging
- 100mg
- Price
- $172
- Updated
- 2021/12/16
5-Amino-1,6-naphthyridine Chemical Properties,Usage,Production
Synthesis
1351516-77-2
55570-60-0
1,6-Naphthyridin-5-amine was synthesized as follows: 5-azido-1,6-diazaphthalene (3.2 g, 18.7 mmol) was dissolved in methanol (30 mL) and stirred at room temperature. Stannous chloride dihydrate (21 g, 93.6 mmol) and concentrated hydrochloric acid (10 mL) were sequentially added to the solution, followed by heating and refluxing the reaction mixture for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and neutralized with saturated sodium bicarbonate solution to pH 7-8. The reaction mixture was filtered and the aqueous phase was extracted with ethyl acetate (5 x 30 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and the solvent was concentrated under reduced pressure to afford 1,6-naphthyridin-5-amine as a light yellow solid (2.20 g, 81% yield), which was used directly in the next step of the reaction. Mass spectrum (ESI MS): m/z 146 [M + H]+. 1H NMR (400 MHz, CDCl3) δ 8.91 (dd, J = 1.6, 4.8 Hz, 1H), 8.62 (d, J = 8.0 Hz, 1H), 8.00 (d, J = 6.0 Hz, 1H), 7.47 (dd, J = 4.8, 8.0 Hz, 1H). 7.09 (br, 2H), 6.98 (d, J = 6.0 Hz, 1H).
References
[1] Patent: US2012/178748, 2012, A1. Location in patent: Page/Page column 45
[2] Patent: WO2013/192273, 2013, A1. Location in patent: Paragraph 00344
5-Amino-1,6-naphthyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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