5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE

Product Name: 5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE
CAS No.: 145858-50-0
Chemical Name: 5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE
Synonyms: R75251;R-75251;R 75251;Liarozole HCl;Liarozole dihydrochl;LIAROZOLE HYDROCHLORIDE;5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE
CBNumber: CB42446477
Molecular Formula: C17H14Cl2N4
Formula Weight: 0
MOL File: 145858-50-0.mol

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5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE Property

storage temp.: Store at +4°C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: L486203
Product name: LiarozoleHydrochloride
Packaging: 10mg
Price: $160
Updated: 2021/12/16

Usbiological

Product number: 453727
Product name: Liarozole Hydrochloride
Packaging: 10mg
Price: $425
Updated: 2021/12/16

Usbiological

Product number: 255684
Product name: Liarozole hydrochloride
Packaging: 10mg
Price: $446
Updated: 2021/12/16

TRC

Product number: L486203
Product name: LiarozoleHydrochloride
Packaging: 50mg
Price: $730
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001227
Product name: LIAROZOLE HYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $1593.9
Updated: 2021/12/16

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5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Antineoplastic.

Uses

Liarozole Hydrochloride is a Imidazole-containing compound that inhibits the cytochrome P450-dependent metabolism.

Biological Activity

Cytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas.

in vivo

Liarozole (5-20 mg/kg; p.o.; 3 days) reverses the vaginal keratosis caused by estrogen stimulation^[5].
Liarozole (40 mg/kg; p.o.; 21 days) reduces tumor burden substantially^[6].

Animal Model:	Ovariectomized rats^[5]
Dosage:	5~20 mg/kg
Administration:	P.o.; 3 days
Result:	Reversed the vaginal keratosis caused by estrogen stimulation.

Animal Model:	SCID mice^[6]
Dosage:	40 mg/kg
Administration:	P.o.; 21 days
Result:	Inhibited tumor growth and survival.

5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE Suppliers

China 7 United Kingdom 1 United States 4 Global 12

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
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Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
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Santa Cruz Biotechnology Inc

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Email: scbt@scbt.com
Country: China
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TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19961
Advantage: 58

Aladdin Scientific

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Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

145858-50-0, 5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDERelated Search:

(3-chlorophenyl)(phenyl)methylamine Liarozole 5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE 1H-Benzimidazole,5-(1H-imidazol-1-ylmethyl)-(9CI) C-(3-CHLORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE

5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE

LIAROZOLE HYDROCHLORIDE

Liarozole dihydrochl

Liarozole HCl

R 75251

R75251

R-75251

145858-50-0

C17H14Cl2N4

C17H13ClN4HCl