N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE
- Product Name
- N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE
- CAS No.
- 421580-53-2
- Chemical Name
- N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE
- Synonyms
- Corrector C4;N-[5-[2-(5-Chloro-2-methoxy-anilino)thiazol-4-yl]-4-methyl-thiazol-2-yl]benzamide;N-[2-(5-CHLORO-2-METHOXY-PHENYLAMINO)-4'-METHYL-[4,5']BITHIAZOLYL-2'-YL]-BENZAMIDE;Benzamide, N-[2-[(5-chloro-2-methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]-;N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE;N-[5-[2-(5-chloro-2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide
- CBNumber
- CB42446947
- Molecular Formula
- C21H17ClN4O2S2
- Formula Weight
- 456.97
- MOL File
- 421580-53-2.mol
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Property
- Density
- 1.440±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 100mg/mL
- pka
- 6.81±0.70(Predicted)
- form
- solid
- color
- light beige
N-Bromosuccinimide Price
- Product number
- HCH0317789
- Product name
- N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.44
- Updated
- 2021/12/16
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Chemical Properties,Usage,Production
General Description
A cell-permeable bisaminomethylbithiazole compound that is reported to rescue/correct the folding defect of CFTR ΔF508 mutant via direct interaction and promote proper trafficking/glycosylation and surface expression in both transfected cells and primary airway epithelial cells from ΔF508-homozygous patients, while exhibiting little correcting effect toward N1303K-CFTR, P574H-CFTR, M345T-DRD4 (dopamine receptor 4), or G268V-ABCA1/CD243 /MDR1/ P-gp mutant. Reported to enhance the folding efficiency of both ΔF508 (by 3-fold at 10μM in FRT cells) and wild-type CFTR (by up to 70%), delay the ER-associated degradation of the core-glycosylated ΔF508 (by 30% at 10μM in FRT cells), and increase the stability of low-temperature resuced ΔF508 mutant on the plasma membrane (by 1.7-fold at 10μM in FRT cells). Corr-4a is shown to be more effective than VRT-325/CFcor-325 n restoring forskolin-stimulated CFTR activity in FRT and A549 ΔF508-CFTR transfectants. Unlike VRT-532 Corr-4a does not affect mutant CFTR channel gating activity.
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 13675144456
- Fax
- 025-85563444
- sean.lv@synzest.com
- Country
- China
- ProdList
- 10784
- Advantage
- 58
- Tel
- 2122619822
- czbjpharma@126.com
- Country
- China
- ProdList
- 18478
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24644
- Advantage
- 58
- Tel
- 14760821013 13564957716
- 1816280386@qq.com
- Country
- China
- ProdList
- 8045
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11974
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29979
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 400-821-026
- sangon@qq.com
- Country
- China
- ProdList
- 47240
- Advantage
- 58