3-METHYL-1,3-THIAZOLANE-2,4-DIONE
- Product Name
- 3-METHYL-1,3-THIAZOLANE-2,4-DIONE
- CAS No.
- 16312-21-3
- Chemical Name
- 3-METHYL-1,3-THIAZOLANE-2,4-DIONE
- Synonyms
- 2,4-Thiazolidinedione, 3-methyl-;3-METHYL-1,3-THIAZOLANE-2,4-DIONE;3-methyl-1,3-thiazolidine-2,4-dione
- CBNumber
- CB4244824
- Molecular Formula
- C4H5NO2S
- Formula Weight
- 131.15
- MOL File
- 16312-21-3.mol
3-METHYL-1,3-THIAZOLANE-2,4-DIONE Property
- Melting point:
- 40-43°C
- Boiling point:
- 130-131 °C(Press: 14 Torr)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -2.27±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C4H5NO2S/c1-5-3(6)2-8-4(5)7/h2H2,1H3
- InChIKey
- HMLWNNMYODLLJO-UHFFFAOYSA-N
- SMILES
- S1CC(=O)N(C)C1=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M331458
- Product name
- 3-Methylthiazolidine-2,4-dione
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR926563
- Product name
- 3-Methyl-1,3-thiazolane-2,4-dione
- Purity
- 95%
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 045402
- Product name
- 3-Methyl-1,3-thiazolane-2,4-dione
- Purity
- >95%
- Packaging
- 500mg
- Price
- $181
- Updated
- 2021/12/16
- Product number
- OR926563
- Product name
- 3-Methyl-1,3-thiazolane-2,4-dione
- Purity
- 95%
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 045402
- Product name
- 3-Methyl-1,3-thiazolane-2,4-dione
- Purity
- >95%
- Packaging
- 1g
- Price
- $228
- Updated
- 2021/12/16
3-METHYL-1,3-THIAZOLANE-2,4-DIONE Chemical Properties,Usage,Production
Uses
3-methyl-1,3-thiazolidine-2,4-dione can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
To a solution of 2,4-thiazolidinedione (1 equiv) in 5 mL of DMF was added potassium carbonate (1.1 equiv) and halogen (1.1 equiv). The suspension was stirred at 80 oC overnight. Solvent was evaporated and the residue was purified by flash column chromatography ( petroleum ether/EtOAc, 5:1) to afford the product 3. 3-Methylthiazolidine-2,4-dione (3a) Following the previous procedure, 2,4-thiazolidinedione (500 mg, 4.3 mmol) and iodomethane (0.3 mL, 4.7 mmol). 3a as white solid (460 mg, 82%).
References
[1] Journal of Chemical Research, 2005, # 8, p. 492 - 494
[2] Organic and Biomolecular Chemistry, 2011, vol. 9, # 10, p. 3801 - 3807
[3] Organic Letters, 2015, vol. 17, # 6, p. 1361 - 1364
[4] Patent: WO2012/137181, 2012, A1. Location in patent: Page/Page column 136-137
[5] Patent: WO2017/176812, 2017, A1. Location in patent: Paragraph 0503
3-METHYL-1,3-THIAZOLANE-2,4-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
3-METHYL-1,3-THIAZOLANE-2,4-DIONE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-57903446 15869909019
- Fax
- 010-57903446
- 168931144@qq.com
- Country
- China
- ProdList
- 2875
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 0371-53765687 18937137882
- Fax
- QQ:2885373884
- 2853979813@qq.com
- Country
- China
- ProdList
- 7991
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13127280945
- 285424065@qq.com
- Country
- China
- ProdList
- 9976
- Advantage
- 55
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 021-000000 13917643586;
- admin@jingshipharmatech.com
- Country
- China
- ProdList
- 9856
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-18017654 18017654809
- Fax
- 2271705492
- sales@vigorchem.cn
- Country
- China
- ProdList
- 958
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19987
- Advantage
- 58
- Tel
- +86-0086-577-64498589 +86-15355981851
- Fax
- 0086-577-56994596
- sales@win-winchemical.com
- Country
- China
- ProdList
- 14359
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- +86-021-021-50872116 +8613122107989
- contact@fuxinpharm.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- +8613580539051
- joe@yuhengpharm.com
- Country
- CHINA
- ProdList
- 21142
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 021-50872116 13611907556
- Fax
- 021-31300828
- contact@fuxinpharm.com
- Country
- China
- ProdList
- 1611
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39665
- Advantage
- 58
- Tel
- +86(21)5895 0110 19945755304
- sales@chemany.com
- Country
- China
- ProdList
- 9984
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- hanfangpharma@126.com; 18616537568
- hanfangpharma@126.com
- Country
- China
- ProdList
- 29965
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 14580
- Advantage
- 58
- Tel
- 021-60936350
- scbt@scbt.com
- Country
- China
- ProdList
- 6594
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 33024
- Advantage
- 60
- Tel
- +86-512-68323658 +86-18168183658
- sales1@artkmedchem.com
- Country
- China
- ProdList
- 39002
- Advantage
- 58
- Tel
- +86-571-87711850
- market18@leapchem.com
- Country
- China
- ProdList
- 43339
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
- Tel
- --
- Fax
- --
- yihbio@163.com
- Country
- CHINA
- ProdList
- 6184
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15810802415@139.com
- Country
- CHINA
- ProdList
- 6750
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6906
- Advantage
- 58
- Tel
- --
- Fax
- --
- jingkehuaxue@163.com
- Country
- CHINA
- ProdList
- 6141
- Advantage
- 58
- Tel
- --
- Fax
- --
- shqcsw01@163.com
- Country
- CHINA
- ProdList
- 6821
- Advantage
- 58
- Tel
- --
- Fax
- --
- shizezjp@163.com
- Country
- CHINA
- ProdList
- 6174
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6973
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15821073967@163.com
- Country
- CHINA
- ProdList
- 6748
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1562893815@qq.com
- Country
- CHINA
- ProdList
- 6936
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3245176082@qq.com
- Country
- CHINA
- ProdList
- 6800
- Advantage
- 58
- Tel
- --
- Fax
- --
- shhebio@126.com
- Country
- CHINA
- ProdList
- 6137
- Advantage
- 58