4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE

Product Name: 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE
CAS No.: 663194-10-3
Chemical Name: 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE
Synonyms: 4-(4-Bromopyrimidin-2-yl);4-BROMO-2-MORPHOLINOPYRIMIDINE;4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE;Morpholine, 4-(4-bromo-2-pyrimidinyl)-;4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE ISO 9001：2015 REACH
CBNumber: CB42448264
Molecular Formula: C8H10BrN3O
Formula Weight: 244.09
MOL File: 663194-10-3.mol

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4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE Property

Boiling point:: 382.8±52.0 °C(Predicted)
Density: 1.570±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.03±0.40(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB144262
Product name: 4-(4-Bromopyrimidin-2-yl)morpholine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144262
Product name: 4-(4-Bromopyrimidin-2-yl)morpholine
Packaging: 500mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144262
Product name: 4-(4-Bromopyrimidin-2-yl)morpholine
Packaging: 1g
Price: $214
Updated: 2021/12/16

Matrix Scientific

Product number: 072239
Product name: 4-(4-Bromopyrimidin-2-yl)morpholine
Purity: 95+%
Packaging: 250mg
Price: $260
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144262
Product name: 4-(4-Bromopyrimidin-2-yl)morpholine
Packaging: 2g
Price: $372
Updated: 2021/12/16

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4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE Chemical Properties,Usage,Production

Synthesis

110-91-8

3921-01-5

663194-10-3

1209459-32-4

A solution of tetrahydrofuran (10 mL) of 2,4-dibromopyrimidine (438.4 mg, 1.84 mmol) and potassium carbonate (1.27 g, 9.21 mmol) was mixed and stirred at room temperature for 5 min. Subsequently, morpholine (174.8 μL, 2.03 mmol) was added dropwise and the reaction mixture continued to be stirred at room temperature for 5 hours. Upon completion of the reaction, the mixture was filtered, the filtrate was collected and the solvent was removed by concentration under reduced pressure. The crude product was purified by silica gel column chromatography using hexane and ethyl acetate as eluents to afford 4-(4-bromopyrimidin-2-yl)morpholine (28a) and 4-(2-bromopyrimidin-4-yl)morpholine (28b) in 19% and 66% yields, respectively. 4-(4-Bromopyrimidin-2-yl)morpholine (28a): white solid in 19% yield.1H NMR (500 MHz, CDCl3) δ ppm 3.74-3.77 (m, 4H), 3.79-3.83 (m, 4H), 6.70 (d, J = 4.88 Hz, 1H), 8.05 (d, J = 4.88 Hz, 1H). LCMS m/z found 246.0, [M + H]+. 4-(2-Bromopyrimidin-4-yl)morpholine (28b): white solid, 66% yield.1H NMR (500 MHz, CDCl3) δ ppm 3.66 (br.s, 4H), 3.76-3.83 (m, 4H), 6.43 (d, J = 6.35 Hz, 1H), 8.02 (d, J = 6.35 Hz, 1H).LCMS m /z found 246.0, [M + H]+.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 141, p. 446 - 459

4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE Suppliers

China 48 Germany 1 India 1 United Kingdom 1 United States 4 Global 55

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View Lastest Price from 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE manufacturers

Dideu Industries Group Limited

Product: 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE 663194-10-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-02

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE 663194-10-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE 663194-10-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

663194-10-3, 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINERelated Search:

2-Pyrimidinamine, 4-bromo- (9CI) Pyrimidine, 4-bromo- (8CI,9CI) 4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE

4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE

4-BROMO-2-MORPHOLINOPYRIMIDINE

4-(4-Bromopyrimidin-2-yl)

Morpholine, 4-(4-bromo-2-pyrimidinyl)-

4-(4-BROMOPYRIMIDIN-2-YL)MORPHOLINE ISO 9001：2015 REACH

663194-10-3