(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE
- Product Name
- (2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE
- CAS No.
- 117077-93-7
- Chemical Name
- (2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE
- Synonyms
- 2,6-dichloro-N,N-diMethylpyriMidin-4-aMine;4-dimethylamino-2,6-dichloropyrimidine;2,6-Dichloro-N,N-dimethyl-4-pyrimidinamine;4-Pyrimidinamine, 2,6-dichloro-N,N-dimethyl-;(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE
- CBNumber
- CB42449988
- Molecular Formula
- C6H7Cl2N3
- Formula Weight
- 192.05
- MOL File
- 117077-93-7.mol
(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE Property
- Melting point:
- 113 °C
- Boiling point:
- 306.1±22.0 °C(Predicted)
- Density
- 1.393±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.58±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D436208
- Product name
- 2,6-Dichloro-N,N-dimethylpyrimidin-4-amine
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-W000694
- Product name
- 2,6-Dichloro-N,N-dimethylpyrimidin-4-amine
- Packaging
- 100mg
- Price
- $102
- Updated
- 2021/12/16
- Product number
- 1944AQ
- Product name
- 2,6-dichloro-N,N-dimethylpyrimidin-4-amine
- Packaging
- 100mg
- Price
- $194
- Updated
- 2021/12/16
- Product number
- 1944AQ
- Product name
- 2,6-dichloro-N,N-dimethylpyrimidin-4-amine
- Packaging
- 250mg
- Price
- $323.6
- Updated
- 2021/12/16
- Product number
- HCH0356121
- Product name
- (2,6-DICHLORO-PYRIMIDIN-4-YL)DIMETHYL-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.52
- Updated
- 2021/12/16
(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE Chemical Properties,Usage,Production
Synthesis
3764-01-0
506-59-2
117077-93-7
Under argon protection, 2,4,6-trichloropyrimidine (10 g, 54.64 mmol) was dissolved in dichloromethane (300 mL), cooled to -78 °C and stirred. Subsequently, dimethylamine hydrochloride (4.45 g, 54.64 mmol) was added to this solution. Triethylamine (15.22 mL, 109.29 mmol) was added slowly and the reaction temperature was kept at -78 °C with stirring for 2 hours, followed by a gradual warming to 0 °C over 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with water (150 mL) and extracted with dichloromethane (2 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with 20% ethyl acetate/hexane as eluent to afford the target compound 2,6-dichloro-4-N,N-dimethylaminopyrimidine (8.1 g, 77% yield) as a white solid.TLC conditions: 10% ethyl acetate/hexane (Rf 0.4).1H-NMR (500 MHz, DMSO-d6): δ 6.82 (s 1H), 3.09 (s, 6H).
References
[1] Patent: WO2016/168619, 2016, A1. Location in patent: Paragraph 00194
[2] Patent: US2004/82587, 2004, A1. Location in patent: Page/Page column 12
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3408 - 3413
(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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