PSYCHOSINE
- Product Name
- PSYCHOSINE
- CAS No.
- 2238-90-6
- Chemical Name
- PSYCHOSINE
- Synonyms
- PSYCHOSIN;PSYCHOSINE;PSYCHOSINE(RG);LYSO-CEREBROSIDE;PSYCHOSINE USP/EP/BP;Galactosylsphingosine;O-Galactosylsphingosine;Psychosine (free amine);Sphingosine galactoside;LYSO-CERAMIDEGALACTOSIDE
- CBNumber
- CB4245038
- Molecular Formula
- C24H47NO7
- Formula Weight
- 461.63
- MOL File
- 2238-90-6.mol
PSYCHOSINE Property
- Melting point:
- 190 °C (decomp)
- Boiling point:
- 664.3±55.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform/Methanol/DI water (5:1:0.1): soluble; Ethanol: soluble
- form
- lyophilized powder
- pka
- 11.74±0.45(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H370Causes damage to organs
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- P9256
- Product name
- Psychosine from bovine brain
- Purity
- lyophilized powder, ≥98% (TLC)
- Packaging
- 1mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- P9256
- Product name
- Psychosine from bovine brain
- Purity
- lyophilized powder, ≥98% (TLC)
- Packaging
- 10mg
- Price
- $506
- Updated
- 2024/03/01
- Product number
- 20338
- Product name
- Galactosylsphingosine (d18:1)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 20338
- Product name
- Galactosylsphingosine (d18:1)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 20338
- Product name
- Galactosylsphingosine (d18:1)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $335
- Updated
- 2024/03/01
PSYCHOSINE Chemical Properties,Usage,Production
Description
Galactosylsphingosine is a bioactive sphingolipid. It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate . Galactosylsphingosine (0.1 and 1 μM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes. Galactosylsphingosine (10 and 15 μM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells. Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.[Matreya, LLC. Catalog No. 1305]
Uses
Psychosine is a cationic lysosphingolipid that displays neuroprotective effects against quisqualate.
Definition
ChEBI: A glycosylsphingoid consisting of sphingosine having a beta-D-galactosyl residue attached at the 1-position.
General Description
Galactosyl(β) Sphingosine (d18:1) is a substrate for the enzyme endoglycoceramidase I (EGCase I). It has sphingosine backbone with galactose attached to it and is a brain glycospingolipid.
Biochem/physiol Actions
Galatosylsphingosine or psychosine is a cytotoxic lipid which accumulates in oligodendrocytes due to dysfunctional lysosomal enzyme galactosylceramidase and is implicated in globoid cell leukodystrophy. Psychosine accumulation induces demyelination, astrocyte dysfunction and pro-inflammatory cytokine release in Krabbe disease.
Enzyme inhibitor
This cationic brain lysosphingolipid (FWfree-base = 461.64 g/mol; CAS 2238- 90-6), also known as 1-O-b-D-galactosylsphingosine, inhibits metabotropic a1-adrenergic receptor signaling-induced phospholipase C activation in rat brain astrocytes. Psychosine also exerts protective effects against quisqualate, suggesting it may be useful in prophylaxis of neurodegenerative disorders arising from over-stimulation of hippocampal Group 1 metabolotropic glutamate receptor, or mGluR. Psychosine is the product of the reaction catalyzed by sphingosine b-galactosyltransferase and is the substrate for psychosine sulfotransferase and galactosylceramidase. Target(s): cerebroside-sulfatase, or arylsulfatase A; cytochrome c oxidase; cytokinesis; electron transport; galactosylgalactosylglucosylceramidase; glucocerebrosidase, lysosome; b-glucosidase; phosphorylase kinase; protein kinase C (11- 14); protein-tyrosine sulfotransferase; and sphingomyelinase.
PSYCHOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
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