ETHYL 2-FLUOROBENZOYLFORMATE
- Product Name
- ETHYL 2-FLUOROBENZOYLFORMATE
- CAS No.
- 1813-93-0
- Chemical Name
- ETHYL 2-FLUOROBENZOYLFORMATE
- Synonyms
- ETHYL 2-FLUOROBENZOYLFORMATE;Ethyl (2-Fluorophenyl)(Oxo)Acetate;ethyl 2-(2-fluorophenyl)-2-oxoacetate;2-Fluoro-oxo-benzeneacetic acid ethyl ester;Benzeneacetic acid, 2-fluoro-α-oxo-, ethyl ester
- CBNumber
- CB42450832
- Molecular Formula
- C10H9FO3
- Formula Weight
- 196.18
- MOL File
- 1813-93-0.mol
ETHYL 2-FLUOROBENZOYLFORMATE Property
- Boiling point:
- 149-152 °C(Press: 30 Torr)
- Density
- 1.213±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- liquid
- color
- Yellow
Safety
- HazardClass
- IRRITANT
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 9512AA
- Product name
- Ethyl2-(2-fluorophenyl)-2-oxoacetate
- Packaging
- 5g
- Price
- $531
- Updated
- 2021/12/16
- Product number
- HCH0029349
- Product name
- ETHYL 2-FLUOROBENZOYLFORMATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $921.69
- Updated
- 2021/12/16
- Product number
- 14093
- Product name
- Ethyl2-Fluorobenzoylformate
- Purity
- 97%
- Packaging
- 5g
- Price
- $1309
- Updated
- 2021/12/16
- Product number
- HCH0029349
- Product name
- ETHYL 2-FLUOROBENZOYLFORMATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1988.91
- Updated
- 2021/12/16
- Product number
- HCH0029349
- Product name
- ETHYL 2-FLUOROBENZOYLFORMATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $3153.15
- Updated
- 2021/12/16
ETHYL 2-FLUOROBENZOYLFORMATE Chemical Properties,Usage,Production
Synthesis
1072-85-1
95-92-1
1813-93-0
To a stirred solution of 1-bromo-2-fluorobenzene (10 g, 57 mmol) in tetrahydrofuran (100 mL) was slowly added n-butyllithium (25 mL, 62.9 mmol, 2.5 M hexane solution) under nitrogen protection and at -70 °C. After maintaining the reaction at -70°C for 20 minutes, the solution was slowly added dropwise to a solution of diethyl oxalate (39 mL, 285 mmol) in tetrahydrofuran (100 mL). After the dropwise addition was completed, the reaction mixture was gradually warmed to room temperature. After continued stirring for 1 hour at room temperature, the reaction mixture was poured into water (150 mL) and extracted with ethyl acetate (2 x 100 mL). The organic phases were combined and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (240 g) with ethyl acetate/hexane (1:49) as eluent to afford the target compound ethyl 2-(2-fluorophenyl)-2-oxoacetate as a colorless oil (5.6 g, 50% yield). The product was confirmed by 1H NMR (CDCl3): δ 7.95 (m, 1H), 7.62 (m, 1H), 7.35-7.13 (m, 2H), 4.44 (q, J=7.1Hz, 2H), 1.40 (t, J=7.1Hz, 3H). The mass spectrum (ES+) showed the molecular ion peak m/z = 197 (M+H)+.
References
[1] Patent: WO2012/74784, 2012, A2. Location in patent: Page/Page column 23-24
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 16, p. 3726 - 3732
[3] Angewandte Chemie - International Edition, 2014, vol. 53, # 10, p. 2658 - 2661
[4] Angew. Chem., 2014, vol. 126, # 10, p. 2696 - 2699,4
ETHYL 2-FLUOROBENZOYLFORMATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 2-FLUOROBENZOYLFORMATE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 13651987816
- Fax
- -
- hongminpharm@163.com
- Country
- China
- ProdList
- 2326
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58