ChemicalBook > CAS DataBase List > CAY10576

CAY10576

Product Name
CAY10576
CAS No.
862812-98-4
Chemical Name
CAY10576
Synonyms
CAY10576;IKK-3 Inhibitor;GSK-319347A,GSK319347A;GSK319347A, 10 mM in DMSO;IKK-epsilon Kinase Inhibitor II, Inhibitor of IkappaB kinases (IKK);5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(2-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrile;5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile;2-Thiophenecarbonitrile, 5-(5,6-diMethoxy-1H-benziMidazol-1-yl)-3-[[2-(Methylsulfonyl)phenyl]Methoxy]-
CBNumber
CB42454234
Molecular Formula
C22H19N3O5S2
Formula Weight
469.53
MOL File
862812-98-4.mol
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CAY10576 Property

Boiling point:
744.4±70.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 45 mg/mL (95.84 mM; Need ultrasonic)
form 
Powder
pka
3.09±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10011249
Product name
CAY10576
Purity
≥95%
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
10011249
Product name
CAY10576
Purity
≥95%
Packaging
5mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
10011249
Product name
CAY10576
Purity
≥95%
Packaging
10mg
Price
$351
Updated
2024/03/01
Cayman Chemical
Product number
10011249
Product name
CAY10576
Purity
≥95%
Packaging
50mg
Price
$1528
Updated
2024/03/01
TRC
Product number
G797610
Product name
GSK319347A
Packaging
50mg
Price
$1010
Updated
2021/12/16
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CAY10576 Chemical Properties,Usage,Production

Uses

GSK 319347A is a potent and selective IKKε kinase inhibitor.

Definition

ChEBI: 5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile is a member of benzimidazoles.

Biological Activity

Cell permeable: no', 'Primary Target
IKK-3', 'Product competes with ATP.', 'Reversible: no', 'Target IC50: 40 nM against IKK-3 (IKK-ε)

IC 50

TBK1: 93 nM (IC50); IKK-ε: 469 nM (IC50); IKK2: 790 nM (IC50)

storage

Store at -20°C

CAY10576 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10576 Suppliers

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862812-98-4, CAY10576Related Search:

CAY10576

  • CAY10576
  • IKK-3 Inhibitor
  • 2-Thiophenecarbonitrile, 5-(5,6-diMethoxy-1H-benziMidazol-1-yl)-3-[[2-(Methylsulfonyl)phenyl]Methoxy]-
  • 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
  • 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(2-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrile
  • GSK-319347A,GSK319347A
  • IKK-epsilon Kinase Inhibitor II, Inhibitor of IkappaB kinases (IKK)
  • GSK319347A, 10 mM in DMSO
  • 862812-98-4