ChemicalBook > CAS DataBase List > 5-(CHLOROMETHYL)-2-METHOXYPYRIDINE

5-(CHLOROMETHYL)-2-METHOXYPYRIDINE

Product Name: 5-(CHLOROMETHYL)-2-METHOXYPYRIDINE
CAS No.: 101990-70-9
Chemical Name: 5-(CHLOROMETHYL)-2-METHOXYPYRIDINE
Synonyms: 2-methoxy-5-chloromethylpyridine;-(CHLOROMETHYL)-2-METHOXYPYRIDINE;5-(CHLOROMETHYL)-2-METHOXYPYRIDINE;5-(ChloroMerthyl)-2-Methoxy pyridine;Pyridine, 5-(chloroMethyl)-2-Methoxy-
CBNumber: CB42454441
Molecular Formula: C7H8ClNO
Formula Weight: 157.6
MOL File: 101990-70-9.mol

Less

5-(CHLOROMETHYL)-2-METHOXYPYRIDINE Property

Boiling point:: 236.1±25.0℃ (760 Torr)
Density: 1.173±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 96.6±23.2℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 2.62±0.10(Predicted)
Appearance: Colorless to light yellow Liquid

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: B419733
Product name: 5-(Chloromethyl)-2-methoxypyridine
Packaging: 50mg
Price: $90
Updated: 2021/12/16

TRC

Product number: B419733
Product name: 5-(Chloromethyl)-2-methoxypyridine
Packaging: 250mg
Price: $350
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139378
Product name: 5-(Chloromethyl)-2-methoxypyridine
Packaging: 2g
Price: $250
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0367311
Product name: 5-(CHLOROMETHYL)-2-METHOXYPYRIDINE
Purity: 95.00%
Packaging: 250MG
Price: $283.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139378
Product name: 5-(Chloromethyl)-2-methoxypyridine
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Less

5-(CHLOROMETHYL)-2-METHOXYPYRIDINE Chemical Properties,Usage,Production

Uses

5-(Chloromethyl)-2-methoxypyridine is used in preparation of pyrazolopyridine compounds as RET kinase inhibitor for treatment of RET-related diseases.

Synthesis

58584-63-7

101990-70-9

(6-Methoxypyridin-3-yl)methanol (2) (537.8 g, 3.86 mol) obtained in Preparation Example 1 was dissolved in dimethylformamide (1.6 L), cooled in an ice bath under nitrogen protection, and thionyl chloride (310 mL, 4.25 mol) was added slowly and dropwise over a period of 1.3 hours. After the dropwise addition, the reaction mixture was continued to be stirred in an ice bath for 1 hour. Subsequently, toluene (5.4 L) and 2N aqueous sodium hydroxide solution (5.4 L) were sequentially added to the reaction mixture at a temperature not exceeding 23 °C. After stirring for about 10 minutes, the aqueous layer was separated and the organic layer was washed with water (2.7 L). The organic layer was concentrated to dryness under reduced pressure, and toluene (1.0 L) was added to the residue for azeotropic distillation, resulting in 618.8 g of the target product, 5-chloromethyl-2-methoxypyridine (3), as a light yellow oil (556.3 g, 91.4% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ (ppm) 8.15 (1H, d, J=2.4 Hz), 7.63 (1H, dd, J=2.4 Hz, 8.4 Hz), 6.75 (1H, d, J=8.4 Hz), 4.55 (2H, s), 3.94 (3H, s).

References

[1] Patent: WO2016/33445, 2016, A1. Location in patent: Paragraph 0259
[2] Tetrahedron, 2014, vol. 70, # 40, p. 7207 - 7220
[3] Patent: US2006/235225, 2006, A1. Location in patent: Page/Page column 4
[4] Patent: US2007/49632, 2007, A1. Location in patent: Page/Page column 38
[5] Patent: US2011/224225, 2011, A1. Location in patent: Page/Page column 23

5-(CHLOROMETHYL)-2-METHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

5-(CHLOROMETHYL)-2-METHOXYPYRIDINE Suppliers

China 49 India 1 United Kingdom 1 United States 5 Global 56

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Atop Bio-Tech (Tianjin) Co., Ltd. (Atop)

Tel: 022-66200236 18622210341
Fax: +86-022-66200236
Email: sales@atop-biotech.com
Country: China
ProdList: 295
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

BePharm Ltd

Tel: 400-685-9117
Fax: 021-51816740
Email: market@bepharm.com
Country: China
ProdList: 15081
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Suzhou Nuoouman Biological Technology Co., Ltd.

Tel: 15026866316
Email: 180642609@qq.com
Country: China
ProdList: 4967
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Zhijiang City Zhou Yuan Yao Biological Technology Co., LTD

Tel: 15671050515
Fax: -
Email: 2267948566@qq.com
Country: China
ProdList: 480
Advantage: 58

Jinan chemkey pharmaceutical Co., Ltd.

Tel: 15610156652
Email: baimingshi@163.com
Country: China
ProdList: 981
Advantage: 58

Suzhou LaiYue Biotechnology Co., Ltd.

Tel: 15161566723 18100692465 1029125529 1029125529@.com
Email: 1029125529@qq.com
Country: China
ProdList: 291
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

inan new medical technology co., LTD

Tel: 0531-; 18954137585
Fax: 1939458511
Email: 1939458511@qq.com
Country: China
ProdList: 294
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

Shanghai Lanle Bird Industrial Co., Ltd.

Tel: 15021845385
Email: 765325601@qq.com
Country: China
ProdList: 3609
Advantage: 58

Changzhou Yinghao Technology Development Co., Ltd

Tel: 15151934985
Email: sales@yingsapharm.com
Country: China
ProdList: 5181
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26028
Advantage: 58

Shanghai Fine Biotech Co.，Ltd

Tel: 18717800556
Email: sales@finebiotech.com
Country: China
ProdList: 2182
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

ChemeGen

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd

Tel: 15553348166
Email: m15553348166@163.com
Country: China
ProdList: 9967
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Shanghai Jianchao Biotechnology Co., LTD

Tel: 15021035486 18081542813
Email: 1804873256@qq.com
Country: China
ProdList: 6684
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 17301488900
Fax: 025-85560043
Email: judy.xia@synzest.com
Country: China
ProdList: 12582
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-029-81148929 17791530722
Email: 1049@dideu.com
Country: China
ProdList: 10011
Advantage: 58

BEIJINGYIWANJINGRUI

Tel: 15866847540
Email: dengyt2000@163.com
Country: China
ProdList: 4100
Advantage: 58

Shanghai Ken chemical Technology Co.,ltd

Tel: 02152215958
Email: 47697177@qq.com
Country: China
ProdList: 10011
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Ningbo Chaoming Biotechnology Co., Ltd

Tel: 13301662590
Email: mandy@atkchemical.com
Country: China
ProdList: 9343
Advantage: 58

Wuhan Henruixintai Biological Co., Ltd.

Tel: 027-027-65522215 18163303831
Fax: -
Email: 360034463@qq.com
Country: China
ProdList: 1140
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Shenzhen Nexconn Pharmatechs Ltd

Tel: +86-755-89396905 +86-15013857715
Email: admin@nexconn.com
Country: China
ProdList: 10405
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

101990-70-9, 5-(CHLOROMETHYL)-2-METHOXYPYRIDINERelated Search:

6-PHENOXYNICOTINOYL CHLORIDE 5-(Chloromethyl)-2-(tetrahydro-2H-pyran-4-yloxy)pyridine 97% 5-(CHLOROMETHYL)-2-ETHOXYPYRIDINE 2-(BENZYLOXY)-5-(CHLOROMETHYL)PYRIDINE 5-(CHLOROMETHYL)-2-(2,2,2-TRIFLUOROETHOXY)PYRIDINE 5-(CHLOROMETHYL)-2-METHOXY-3-(TRIFLUOROMETHYL)-PYRIDINE 5-(CHLOROMETHYL)-2-METHOXYPYRIDINE 5-(CHLOROMETHYL)-2-METHOXYPYRIDINE HYDROCHLORIDE

5-(CHLOROMETHYL)-2-METHOXYPYRIDINE

5-(ChloroMerthyl)-2-Methoxy pyridine

Pyridine, 5-(chloroMethyl)-2-Methoxy-

-(CHLOROMETHYL)-2-METHOXYPYRIDINE

2-methoxy-5-chloromethylpyridine

101990-70-9