2-CHLORO-6-FORMYLBENZONITRILE
- Product Name
- 2-CHLORO-6-FORMYLBENZONITRILE
- CAS No.
- 77532-86-6
- Chemical Name
- 2-CHLORO-6-FORMYLBENZONITRILE
- Synonyms
- 3-Chloro-2-cyanobenzaldehyde;2-CHLORO-6-FORMYLBENZONITRILE;Benzonitrile, 2-chloro-6-formyl-
- CBNumber
- CB42454946
- Molecular Formula
- C8H4ClNO
- Formula Weight
- 165.58
- MOL File
- 77532-86-6.mol
2-CHLORO-6-FORMYLBENZONITRILE Property
- Melting point:
- 137-138 °C
- Boiling point:
- 323.5±27.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to yellow Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C374133
- Product name
- 2-chloro-6-formylbenzonitrile
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- C374133
- Product name
- 2-chloro-6-formylbenzonitrile
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- X6333
- Product name
- 2-Chloro-6-formylbenzonitrile
- Packaging
- 1g
- Price
- $410
- Updated
- 2021/12/16
- Product number
- HCH0071133
- Product name
- 2-CHLORO-6-FORMYLBENZONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $815.85
- Updated
- 2021/12/16
- Product number
- 057632
- Product name
- 2-Chloro-6-formylbenzonitrile
- Purity
- 95%
- Packaging
- 500mg
- Price
- $177
- Updated
- 2021/12/16
2-CHLORO-6-FORMYLBENZONITRILE Chemical Properties,Usage,Production
Synthesis
77532-80-0
77532-86-6
General procedure for the synthesis of 2-chloro-6-formylbenzonitrile (III-B) from the compound (CAS: 77532-80-0): to a solution of IV-B (18.0 g, 58.2 mmol) in acetonitrile (60 mL) was added an aqueous solution of silver nitrate (AgNO3, 39.5 g, 23.3 mmol) (32 mL). The resulting yellow suspension was refluxed for 20 min. The solids were removed by filtration and washed with dichloromethane (150 mL). The combined filtrates were washed with water (25 mL), dried over sodium sulfate (Na2SO4) and subsequently concentrated under vacuum. The crude product was purified by rapid chromatography on silica gel (eluent: hexane/ethyl acetate, 2/1) to afford pure III-B, 8.67 g (90% yield).1H-NMR (300 MHz, CDCl3): δ 7.72 (t, J = 7.9 Hz, 1H), 7.79 (dd, J = 1.2, 7.9 Hz, 1H), 7.94 (dd, J = 1.2, 7.9 Hz, 1H), 10.31 (s, 1H) ppm. 13C-NMR (75.4 MHz, CDCl3): δ 112.9 (C), 114.4 (C), 127.5 (CH), 133.8 (CH), 134.9 (CH), 138.5 (C), 139.0 (C), 187.6 (CH) ppm. IR (HATR): 3069, 2865, 2221, 1697, 1584, 1566, 1443, 1395, 1291, 1224, 1195, 1182, 1155, 922, 798, 781, 726, 675 cm-1. EI-MS m/z (% relative intensity): 167 (5); 165 (15), 139 (33), 137 (100), 110 (24), 101 (44), 84 (13), 75 (79), 61 (23), 50 (45). Melting point: 140°C.
References
[1] Tetrahedron Asymmetry, 2009, vol. 20, # 17, p. 1962 - 1968
[2] Patent: US2012/77989, 2012, A1. Location in patent: Page/Page column 7-8
[3] Journal of Organic Chemistry, 2008, vol. 73, # 18, p. 7361 - 7364
[4] Patent: US4244966, 1981, A
2-CHLORO-6-FORMYLBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-6-FORMYLBENZONITRILE manufacturers
- Product
- 2-CHLORO-6-FORMYLBENZONITRILE 77532-86-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25