4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- Product Name
- 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- CAS No.
- 214342-63-9
- Chemical Name
- 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- Synonyms
- 4-BroMo-1-Methylpyridin-2...;4-Bromo-1-methylpyridin-2-one;4-bromo-1-methyl-2-pyridinone;4-Bromo-1-methylpyridin-2-one 4;4-Bromo-1-methyl-2(1H)-pyridinone;4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE;4-BroMo-1-Methyl-1H-pyridin-2-one;2(1H)-Pyridinone, 4-bromo-1-methyl-;4-broMo-1-Methyl-1,2-dihydropyridin-2-one;4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE ISO 9001：2015 REACH
- CBNumber
- CB42457770
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 214342-63-9.mol
4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Property
- Melting point:
- 107-110°
- Boiling point:
- 258℃
- Density
- 1.664
- Flash point:
- 110℃
- storage temp.
- Inert atmosphere,2-8°C
- form
- solid
- pka
- -1.45±0.62(Predicted)
- color
- Beige
- InChI
- InChI=1S/C6H6BrNO/c1-8-3-2-5(7)4-6(8)9/h2-4H,1H3
- InChIKey
- YFOQSLIPUHGGQE-UHFFFAOYSA-N
- SMILES
- C1(=O)N(C)C=CC(Br)=C1
Safety
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B697613
- Product name
- 4-Bromo-1-methylpyridin-2(1H)-one
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB144155
- Product name
- 4-Bromo-1-methylpyridin-2(1H)-one
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 074122
- Product name
- 4-Bromo-1-methylpyridin-2(1H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- OR41149
- Product name
- 4-Bromo-1-methylpyridin-2(1H)-one
- Purity
- 98%
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 4H17-9-05
- Product name
- 4-Bromo-1-methylpyridin-2-one
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Chemical Properties,Usage,Production
Uses
4-Bromo-1-methylpyridin-2-one is used as an important intermediate in medicinal chemistry and organic synthesis.
Hazard
4-Bromo-1-methylpyridin-2(1H)-one is harmful if swalowed, it causes skin irritation and serious eye irritation.
Synthesis
36953-37-4
74-88-4
214342-63-9
1. 4-Bromo-2-hydroxypyridine (1.0 g, 5.75 mmol) was dissolved in tetrahydrofuran (20 mL). 2. The reaction mixture was cooled to 0 °C under nitrogen atmosphere. 3. sodium hydride (60% dispersed in mineral oil, 0.23 g, 5.75 mmol) was added slowly. 4. Gradually warm the mixture to room temperature and stir for 15 minutes. 5. Add iodomethane (1.10 mL, 17.24 mmol) dropwise. 6. Continue stirring the reaction mixture for 16 hours at room temperature. 7. Monitor the progress of the reaction by thin layer chromatography (TLC) to confirm the completion of the reaction. 8. 8. Upon completion of the reaction, water and ethyl acetate were added for extraction. 9. 9. The organic and aqueous phases were separated. 10. The organic phase is washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. 11. Concentrate the organic phase under pressure to obtain N-methyl-4-bromo-2-hydroxypyridine (1.02 g, 94.4% yield).
References
[1] Patent: US2017/112833, 2017, A1. Location in patent: Paragraph 0674-0675
[2] Synlett, 2015, vol. 26, # 11, p. 1557 - 1562
[3] Patent: CN105884695, 2016, A. Location in patent: Paragraph 0357; 0358; 0359
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 23, p. 7076 - 7080
4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE manufacturers
- Product
- 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE 214342-63-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-27
- Product
- 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE 214342-63-9
- Price
- US $20.00-260.00/KG
- Min. Order
- 25G
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2018-08-03