2,6-DICHLORO-N-METHYL-4-PYRIMIDINAMINE
- Product Name
- 2,6-DICHLORO-N-METHYL-4-PYRIMIDINAMINE
- CAS No.
- 32998-03-1
- Chemical Name
- 2,6-DICHLORO-N-METHYL-4-PYRIMIDINAMINE
- Synonyms
- 2,6-DICHLORO-N-METHYL-4-PYRIMIDINAMINE;4-Pyrimidinamine, 2,6-dichloro-N-methyl-
- CBNumber
- CB42460259
- Molecular Formula
- C5H5Cl2N3
- Formula Weight
- 178.02
- MOL File
- 32998-03-1.mol
2,6-DICHLORO-N-METHYL-4-PYRIMIDINAMINE Property
- Melting point:
- 186 °C
- Boiling point:
- 314.7±22.0 °C(Predicted)
- Density
- 1.492±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.77±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D476108
- Product name
- 2,6-dichloro-N-methylpyrimidin-4-amine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0362944
- Product name
- 2,6-DICHLORO-N-METHYLPYRIMIDIN-4-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.22
- Updated
- 2021/12/16
- Product number
- CM124976
- Product name
- 2,6-dichloro-N-methylpyrimidin-4-amine
- Purity
- 95%
- Packaging
- 5g
- Price
- $636
- Updated
- 2021/12/16
- Product number
- CD11144111
- Product name
- 2,6-Dichloro-N-methylpyrimidin-4-amine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $673
- Updated
- 2021/12/16
- Product number
- 32998031
- Product name
- 2,6-Dichloro-N-methylpyrimidin-4-amine
- Packaging
- 5g
- Price
- $680
- Updated
- 2021/12/16
2,6-DICHLORO-N-METHYL-4-PYRIMIDINAMINE Chemical Properties,Usage,Production
Synthesis
3764-01-0
74-89-5
10397-15-6
32998-03-1
The general procedure for the synthesis of 4,6-dichloro-N-methylpyrimidin-2-amine and 2,6-dichloro-N-methylpyrimidin-4-amine from 2,4,6-trichloropyrimidine (0.50 g, 2.7 mmol) and monomethylamine (2 M THF solution, 3.0 mL, 6.0 mmol) was as follows: 2,4,6-trichloropyrimidine was dissolved in THF (3 mL), followed by dropwise THF solution of monomethylamine was added. The reaction mixture was slowly warmed to room temperature and stirred continuously for 30 min, and the formation of the target product was confirmed by LCMS monitoring. Upon completion of the reaction, the reaction was quenched with deionized water (10 mL) and extracted with ethyl acetate (2 × 10 mL). The organic phases were combined, washed with saturated saline (10 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate gradient, 0-30% ethyl acetate) to isolate 2,6-dichloro-N-methyl-4-pyrimidinamine (180 mg, 1.01 mmol, 38% yield) and 4,6-dichloro-N-methyl-2-pyrimidinamine (150 mg, 0.85 mmol, 31% yield). The mass spectra (ES+) of both compounds showed m/e 178 [M+H]+.
References
[1] Nucleosides and Nucleotides, 1994, vol. 13, # 8, p. 1769 - 1777
[2] Patent: WO2008/105968, 2008, A1. Location in patent: Page/Page column 66-67
[3] Journal fuer Praktische Chemie (Leipzig), 1927, vol. <2> 115, p. 293
[4] Patent: US9433621, 2016, B2. Location in patent: Page/Page column 113; 114; 115; 116
[5] Patent: WO2010/22121, 2010, A1. Location in patent: Page/Page column 147
2,6-DICHLORO-N-METHYL-4-PYRIMIDINAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-DICHLORO-N-METHYL-4-PYRIMIDINAMINE manufacturers
- Product
- 2,6-DICHLORO-N-METHYL-4-PYRIMIDINAMINE 32998-03-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-14