N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA

Product Name: N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA
CAS No.: 145231-35-2
Chemical Name: N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA
Synonyms: Clobenpropit (hydrobromide);Clobenpropit dihydrobromide, H3 antagonist;Clobenpropit dihydrobromide Solution, 100ppm;Clobenpropit dihydrobromide Solution, 1000ppm;3-(1H-Imidazol-4-yl)propyl 4-Chlorobenzylcarbamimidothioate Dihydrobromide;Apoptosis,inhibit,Clobenpropit dihydrobromide,histamine H3R,antagonist,inverse,Inhibitor,pancreatic,agonist,cancer,H3LR,Histamine Receptor
CBNumber: CB42463700
Molecular Formula: C14H17ClN4S.2BrH
Formula Weight: 470.659
MOL File: 145231-35-2.mol

More

Less

N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA Property

Melting point:: 205°C(lit.)
storage temp.: Store at -20°C
solubility: DMSO: 30 mg/ml; Ethanol: 2.5 mg/ml; Water: 20 mg/ml
form: powder to crystal
color: White to Gray to Red
Water Solubility: Soluble to 100 mM in water

More

Less

Safety

HS Code: 2933.29.4300

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: C3446
Product name: Clobenpropit Dihydrobromide
Purity: >97.0%(HPLC)
Packaging: 25mg
Price: $307
Updated: 2025/07/31

Cayman Chemical

Product number: 10011126
Product name: Clobenpropit (hydrobromide)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 10011126
Product name: Clobenpropit (hydrobromide)
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 10011126
Product name: Clobenpropit (hydrobromide)
Purity: ≥98%
Packaging: 10mg
Price: $213
Updated: 2024/03/01

Cayman Chemical

Product number: 10011126
Product name: Clobenpropit (hydrobromide)
Purity: ≥98%
Packaging: 25mg
Price: $485
Updated: 2024/03/01

More

Less

N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA Chemical Properties,Usage,Production

Uses

Clobenpropit Dihydrobromide and it’s analogues functions as potent histamine H3 antagonist.

Definition

ChEBI: A hydrobromide salt obtained by reaction of clobenpropit with two equivalents of hydrobromic acid. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.

in vivo

The combination treatment of Clobenpropit (every other day intraperitoneal injection at 20 μM per kilogram for 40 d) and Gemcitabine (twice-a-week intraperitoneal injection at 125 mg/kg for 40 d) shows significant tumor growth inhibition^[3].

Animal Model:	Five-week-old male BALB/c nude mice with Panc-1 xenograft^[3]
Dosage:	20 μM per kilogram
Administration:	Intraperitoneal injection; every other day for 40 days. Gemcitabine (twice-a-week intraperitoneal injection at 125 mg/kg for 40 d)
Result:	The combination treatment showed significant tumor growth inhibition compared with other treatment groups (control 501±92 mg, Gemcitabine 294±46 mg, Clobenpropit 444±167 mg, and combination 154±54 mg).

IC 50

Human H3LR: 9.44 (pKi); Rat H3LR: 9.75 (pKi); H₄ receptor: 13 nM (Ki); H₂ Receptor: 5.6 (pKi)

storage

Store at RT

N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA Suppliers

Americas 1 China 30 Europe 1 India 1 Japan 1 United Kingdom 1 United States 8 USA 1 Global 44

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4511
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15083
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

145231-35-2, N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREARelated Search:

CLOBENPROPIT DIHYDROBROMIDE N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA

Clobenpropit (hydrobromide)

Clobenpropit dihydrobromide Solution, 100ppm

Clobenpropit dihydrobromide Solution, 1000ppm

3-(1H-Imidazol-4-yl)propyl 4-Chlorobenzylcarbamimidothioate Dihydrobromide

Apoptosis,inhibit,Clobenpropit dihydrobromide,histamine H3R,antagonist,inverse,Inhibitor,pancreatic,agonist,cancer,H3LR,Histamine Receptor

Clobenpropit dihydrobromide, H3 antagonist

145231-35-2

C14H19Br2ClN4S