4-AMINO-3-BROMO-2-METHOXYPYRIDINE

Product Name: 4-AMINO-3-BROMO-2-METHOXYPYRIDINE
CAS No.: 215364-86-6
Chemical Name: 4-AMINO-3-BROMO-2-METHOXYPYRIDINE
Synonyms: 3-broMo-2-Methoxypyridin-4-aMine;3-Bromo-2-methoxy-4-pyridinamine;4-AMINO-3-BROMO-2-METHOXYPYRIDINE;4-Pyridinamine, 3-bromo-2-methoxy-;3-Bromo-2-methoxy-pyridin-4-ylamine
CBNumber: CB42465779
Molecular Formula: C6H7BrN2O
Formula Weight: 203.04
MOL File: 215364-86-6.mol

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4-AMINO-3-BROMO-2-METHOXYPYRIDINE Property

Melting point:: Oil°
Boiling point:: 289.0±35.0 °C(Predicted)
Density: 1.622±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 5.28±0.42(Predicted)
Appearance: yellow solid
InChI: InChI=1S/C6H7BrN2O/c1-10-6-5(7)4(8)2-3-9-6/h2-3H,1H3,(H2,8,9)
InChIKey: FJBMTFANAYFWPT-UHFFFAOYSA-N
SMILES: C1(OC)=NC=CC(N)=C1Br

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B428995
Product name: 3-bromo-2-methoxypyridin-4-amine
Packaging: 100mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-3Q
Product name: 3-Bromo-2-methoxypyridin-4-amine
Purity: 95%
Packaging: 1g
Price: $224
Updated: 2021/12/16

Matrix Scientific

Product number: 048511
Product name: 3-Bromo-2-methoxy-4-pyridinamine
Purity: >95%
Packaging: 500mg
Price: $252
Updated: 2021/12/16

Matrix Scientific

Product number: 048511
Product name: 3-Bromo-2-methoxy-4-pyridinamine
Purity: >95%
Packaging: 1g
Price: $335
Updated: 2021/12/16

AK Scientific

Product number: 0947AB
Product name: 3-Bromo-2-methoxypyridin-4-amine
Packaging: 1g
Price: $502
Updated: 2021/12/16

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4-AMINO-3-BROMO-2-METHOXYPYRIDINE Chemical Properties,Usage,Production

Synthesis

20265-39-8

215364-86-6

Synthesis of 3-bromo-2-methoxypyridin-4-amine (2): 2-Methoxypyridin-4-amine (1, 20.0 g, 161.2 mmol) was dissolved in dichloromethane (200 mL) at 0 °C. To this solution, N-bromosuccinimide (26.6 g, 161.2 mmol) was slowly added, followed by warming the reaction mixture to 30 °C and stirring for 30 min. Upon completion of the reaction, the reaction was quenched with ice-cold water (100 mL) and the reaction mixture was extracted with dichloromethane (300 mL). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was ground with a solvent mixture of n-pentane and ether to give 3-bromo-2-methoxypyridin-4-amine (2) as a yellow solid. Yield: 30.0 g, 92% yield; MS (ESI) m/z 203.09 [M + 1]+.

References

[1] Patent: US2017/145026, 2017, A1. Location in patent: Paragraph 0719; 0720
[2] Patent: WO2016/124508, 2016, A1. Location in patent: Page/Page column 60; 61
[3] Patent: CN107151240, 2017, A. Location in patent: Paragraph 0498; 0499; 0500
[4] Patent: US2018/244667, 2018, A1. Location in patent: Paragraph 0106
[5] Tetrahedron, 2008, vol. 64, # 12, p. 2772 - 2782

4-AMINO-3-BROMO-2-METHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-3-BROMO-2-METHOXYPYRIDINE Suppliers

China 72 Germany 1 India 2 United Kingdom 1 United States 5 Global 81

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Synchem OHG

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215364-86-6, 4-AMINO-3-BROMO-2-METHOXYPYRIDINERelated Search:

4-AMINO-3-BROMO-2-METHOXYPYRIDINE

3-Bromo-2-methoxy-4-pyridinamine

3-broMo-2-Methoxypyridin-4-aMine

3-Bromo-2-methoxy-pyridin-4-ylamine

4-Pyridinamine, 3-bromo-2-methoxy-

215364-86-6

amine|alkyl bromide