KU-0063794

ChemicalBook > CAS DataBase List > KU-0063794

Product Name: KU-0063794
CAS No.: 938440-64-3
Chemical Name: KU-0063794
Synonyms: CS-28;KU0063794;KU 0063794, >=98%;KU0063794(KU63794);KU-0063794 USP/EP/BP;Pholcodine Impurity 8;KU-0063794(KU 0063794);mTOR Inhibitor IV, Ku-63794;KU-0063794;KU 0063794; KU0063794;mTOR Inhibitor IV Ku-63794 Ku63794
CBNumber: CB42468008
Molecular Formula: C25H31N5O4
Formula Weight: 465.54
MOL File: 938440-64-3.mol

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KU-0063794 Property

Boiling point:: 694.3±65.0 °C(Predicted)
Density: 1.248
storage temp.: 2-8°C
solubility: DMSO: >2mg/mL (warmed)
pka: 14.20±0.10(Predicted)
form: powder
color: white to beige
InChIKey: RFSMUFRPPYDYRD-CALCHBBNSA-N

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0382
Product name: KU 0063794
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $163
Updated: 2024/03/01

Sigma-Aldrich

Product number: 475990
Product name: mTOR Inhibitor IV, Ku-63794
Packaging: 5mg
Price: $289
Updated: 2024/03/01

Cayman Chemical

Product number: 13597
Product name: KU 0063794
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 13597
Product name: KU 0063794
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0382
Product name: KU 0063794
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $525
Updated: 2024/03/01

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KU-0063794 Chemical Properties,Usage,Production

Description

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival. Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC₅₀ = 10 nM). It does not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks. Ku-0063794 inhibits cell growth by inducing G₁-cell cycle arrest and autophagy, but not apoptosis, and inhibits tumor growth in a xenograft model of renal cell carcinoma (8 mg/kg for 46 days).

Uses

KU 0063794 has been used:

as a mammalian target of rapamycin (mTOR) inhibitor to study the effects of follicular stimulating hormone (FSH) in mTOR phosphorylation and vascular cell adhesion molecule-1 (VCAM-1) expression in?human umbilical vascular endothelial cells (HUVECs)
as a mTOR inhibitor to treat effector memory (EM) CD8⁺ T cells for metabolic flux analysis
as an autophagy inducer to demonstrate the utility of p62 and LC3B-II quantification in HEK293T cells and primary cultures of rat neurons and astrocytes using time-resolved fluorescence resonance energy transfer (TR-FRET)

Uses

Ku 0063794 is a specific mammalian target of rapamycin (mTOR) inhibitor and may be used for the treatment of cancers.

Definition

ChEBI: A member of the class of pyridopyrimidines that is an mTOR inhibitor and shows anti-tumour properties.

Biological Activity

Selective inhibitor of mammalian target of rapamycin (mTOR) (IC 50 ~10 nM for mTORC1 and mTORC2 respectively). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G 1 cell cycle arrest in vitro .

Biochem/physiol Actions

KU 0063794 induces autophagy. It is cell-permeant and suppresses activation and hydrophobic motif phosphorylation of protein kinase B (Akt), p70 ribosomal S6 kinase (S6K) and serum and glucocorticoid protein kinase (SGK).

storage

Room temperature

KU-0063794 Preparation Products And Raw materials

Raw materials

Preparation Products

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KU-0063794 Suppliers

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View Lastest Price from KU-0063794 manufacturers

Career Henan Chemical Co

Product: KU-0063794 938440-64-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

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KU0063794(KU63794)

KU-0063794(KU 0063794)

CS-28

mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem

BENZENEMETHANOL, 5-[2-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-4-(4-MORPHOLINYL)PYRIDO[2,3-D]PYRIMIDIN-7

5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol KU-0063794

KU-0063794,Etoposide,Etopl,Vepeside.

KU 0063794, >=98%

KU-0063794;KU 0063794; KU0063794

(5-(2-((2R,6S)-2,6-Dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxypheny

mTOR Inhibitor IV, Ku-63794

KU-0063794 USP/EP/BP

(5-(2-((2S,6R)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

[5-[2-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]-4-morpholino-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl]methanol

(5-(2-(cis-2,6-Dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

mTOR Inhibitor IV Ku-63794 Ku63794

Pholcodine Impurity 8

938440-64-3

C25H31N5O4

Inhibitors

Akt

mTOR

PI3K