ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER
- Product Name
- ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER
- CAS No.
- 27741-65-7
- Chemical Name
- ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER
- Synonyms
- Ethyl cyclobutylideneacetate;Ethyl2-cyclobutylideneacetate;Carbethoxymethylenecyclobutane;Ethyl cyclobutylideneacetate 97%;Cyclobutylidene-acetic acid ethyl ester;2-Cyclobutylideneacetic acid ethyl ester;ethyl 2-cyclobutylideneacetate - [E47017];Acetic acid, cyclobutylidene-, ethyl ester;ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER
- CBNumber
- CB42468538
- Molecular Formula
- C8H12O2
- Formula Weight
- 140.18
- MOL File
- 27741-65-7.mol
ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER Property
- Melting point:
- 21℃
- Boiling point:
- 128-130℃ (2 Torr)
- Density
- 1.124±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2916199590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2660AB
- Product name
- Ethyl2-cyclobutylideneacetate
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- 2323-1-43
- Product name
- Ethyl cyclobutylideneacetate
- Packaging
- 250mg
- Price
- $152
- Updated
- 2021/12/16
- Product number
- 2323-1-43
- Product name
- Ethyl cyclobutylideneacetate
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 2323-1-43
- Product name
- Ethyl cyclobutylideneacetate
- Packaging
- 5G
- Price
- $672
- Updated
- 2021/12/16
- Product number
- 083613
- Product name
- Ethyl cyclobutylideneacetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $414
- Updated
- 2021/12/16
ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
867-13-0
1191-95-3
27741-65-7
A 25 mL THF solution of triethyl phosphonoacetate (44.8 g) was added dropwise to a suspension of THF (150 mL) containing NaH (8.0 g, 60% oil dispersion) over 40 min at 0-10 °C. The reaction mixture was kept at 0-10°C with continued stirring for 0.5 hr. Subsequently, a 25 mL THF solution of cyclobutanone (14.0 g) was added dropwise at the same temperature. The reaction mixture was stirred at 0-10 °C for 2 hours. Next, 50 mL of water was slowly added at 20-30 °C. After removing the organic solvent by distillation under reduced pressure, 150 mL of water was added. The aqueous solution was extracted using MTBE (3 x 100mL). The organic phases were combined and washed with 100 mL of water and subsequently dried with anhydrous MgSO4. After filtration, the solvent was evaporated to give the crude product, which was purified by fractional distillation (81-82 °C/19 mbar) to give 22.2 g (79% yield) of ethyl 2-cyclobutylideneacetate as a colorless liquid. The product was characterized by the following data: 1HNMR (500 MHz, CDCl3) δ 5.58 (m, 1H), 4.13 (q, 2H, J = 7.1 Hz), 3.15-3.12 (m, 2H), 2.85-2.82 (m, 2H), 2.12-2.06 (m, 2H), 1.26 (t, 3H, J = 7.1 Hz); 13C NMR (125 MHz, CDCl3) δ 167.60,166.60,112.38,59.53,33.75,32.32,17.66,14.36; MS (m/z) 140.1; ESI-HRMS m/z calculated for C8H12O2 [M+H]+ 141.0910, found 141.0911.
References
[1] Journal of Organic Chemistry, 2016, vol. 81, # 3, p. 1057 - 1074
[2] Journal of the Chemical Society. Perkin Transactions 2, 1999, # 5, p. 937 - 945
[3] Tetrahedron Letters, 2015, vol. 56, # 45, p. 6287 - 6289
[4] Patent: WO2016/37534, 2016, A1. Location in patent: Page/Page column 19
[5] Patent: US2017/27172, 2017, A1. Location in patent: Paragraph 0203
ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER manufacturers
- Product
- ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER 27741-65-7
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12