N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE

Product Name: N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE
CAS No.: 1026796-81-5
Chemical Name: N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE
Synonyms: N-(4-bromo-2-pyridyl)acetamide;N-(4-BroMopyridin-2-yl)acetaMide;N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE;ACETAMIDE, N-(4-BROMO-2-PYRIDINYL)-;N-(4-Bromopyridin-2-yl)acetamide[N/A
CBNumber: CB42468679
Molecular Formula: C7H7BrN2O
Formula Weight: 215.05
MOL File: 1026796-81-5.mol

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N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE Property

Boiling point:: 385.1±27.0 °C(Predicted)
Density: 1.630±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 13.15±0.70(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B678553
Product name: N-(4-Bromopyridin-2-yl)acetamide
Packaging: 500mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: Z6551
Product name: N-(4-Bromopyridin-2-yl)acetamide
Packaging: 250mg
Price: $122
Updated: 2021/12/16

AK Scientific

Product number: Z6551
Product name: N-(4-Bromopyridin-2-yl)acetamide
Packaging: 1g
Price: $169
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0369704
Product name: N-(4-BROMOPYRIDIN-2-YL)ACETAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $500.84
Updated: 2021/12/16

AK Scientific

Product number: Z6551
Product name: N-(4-Bromopyridin-2-yl)acetamide
Packaging: 5g
Price: $493
Updated: 2021/12/16

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N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE Chemical Properties,Usage,Production

Uses

N-(4-Bromopyridin-2-yl)acetamide is used as a reactant in the preparation of trisubstituted pyridinylimidazoles as potent inhibitors of the clinically resistant L858R/T790M/C797S EGFR mutant.

Synthesis

84249-14-9

75-36-5

1026796-81-5

To a solution of 4-bromopyridin-2-amine (3.11 g, 17.98 mmol) in dichloromethane (60 mL) at 0 °C were sequentially added acetyl chloride (1.406 mL, 19.77 mmol) and pyridine (1.745 mL, 21.57 mmol). The reaction mixture was slowly warmed to room temperature and stirred continuously for 2 hours. Upon completion of the reaction, the reaction was quenched with water and diluted with ethyl acetate. The organic layer was separated, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford N-(4-bromopyridin-2-yl)acetamide (3.82 g, 17.05 mmol, 95% yield) as a white solid. The obtained product could be used in the subsequent reaction without further purification.LCMS (ESI) m/e 215.0 [(M + H)+, calculated value C7H8Br1N2O2, 215.0]; LC/MS retention time (Method A): 2.61 min.

References

[1] Patent: WO2014/140077, 2014, A1. Location in patent: Page/Page column 60
[2] Patent: WO2015/153720, 2015, A1. Location in patent: Page/Page column 20; 21
[3] Patent: WO2017/59085, 2017, A1. Location in patent: Page/Page column 20; 21
[4] Patent: WO2014/78257, 2014, A1. Location in patent: Page/Page column 118
[5] Patent: WO2015/116492, 2015, A1. Location in patent: Page/Page column 80

N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE Suppliers

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View Lastest Price from N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE 1026796-81-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-25

1026796-81-5, N-(4-BROMO-2-PYRIDINYL)-ACETAMIDERelated Search:

ACETAMIDE, N-(4-BROMO-2-PYRIDINYL)-

N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE

N-(4-BroMopyridin-2-yl)acetaMide

N-(4-bromo-2-pyridyl)acetamide

N-(4-Bromopyridin-2-yl)acetamide[N/A

1026796-81-5