N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE
- Product Name
- N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE
- CAS No.
- 1026796-81-5
- Chemical Name
- N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE
- Synonyms
- N-(4-bromo-2-pyridyl)acetamide;N-(4-BroMopyridin-2-yl)acetaMide;N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE;ACETAMIDE, N-(4-BROMO-2-PYRIDINYL)-;N-(4-Bromopyridin-2-yl)acetamide[N/A
- CBNumber
- CB42468679
- Molecular Formula
- C7H7BrN2O
- Formula Weight
- 215.05
- MOL File
- 1026796-81-5.mol
N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE Property
- Boiling point:
- 385.1±27.0 °C(Predicted)
- Density
- 1.630±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 13.15±0.70(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B678553
- Product name
- N-(4-Bromopyridin-2-yl)acetamide
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- Z6551
- Product name
- N-(4-Bromopyridin-2-yl)acetamide
- Packaging
- 250mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- Z6551
- Product name
- N-(4-Bromopyridin-2-yl)acetamide
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- HCH0369704
- Product name
- N-(4-BROMOPYRIDIN-2-YL)ACETAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.84
- Updated
- 2021/12/16
- Product number
- Z6551
- Product name
- N-(4-Bromopyridin-2-yl)acetamide
- Packaging
- 5g
- Price
- $493
- Updated
- 2021/12/16
N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE Chemical Properties,Usage,Production
Uses
N-(4-Bromopyridin-2-yl)acetamide is used as a reactant in the preparation of trisubstituted pyridinylimidazoles as potent inhibitors of the clinically resistant L858R/T790M/C797S EGFR mutant.
Synthesis
84249-14-9
75-36-5
1026796-81-5
To a solution of 4-bromopyridin-2-amine (3.11 g, 17.98 mmol) in dichloromethane (60 mL) at 0 °C were sequentially added acetyl chloride (1.406 mL, 19.77 mmol) and pyridine (1.745 mL, 21.57 mmol). The reaction mixture was slowly warmed to room temperature and stirred continuously for 2 hours. Upon completion of the reaction, the reaction was quenched with water and diluted with ethyl acetate. The organic layer was separated, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford N-(4-bromopyridin-2-yl)acetamide (3.82 g, 17.05 mmol, 95% yield) as a white solid. The obtained product could be used in the subsequent reaction without further purification.LCMS (ESI) m/e 215.0 [(M + H)+, calculated value C7H8Br1N2O2, 215.0]; LC/MS retention time (Method A): 2.61 min.
References
[1] Patent: WO2014/140077, 2014, A1. Location in patent: Page/Page column 60
[2] Patent: WO2015/153720, 2015, A1. Location in patent: Page/Page column 20; 21
[3] Patent: WO2017/59085, 2017, A1. Location in patent: Page/Page column 20; 21
[4] Patent: WO2014/78257, 2014, A1. Location in patent: Page/Page column 118
[5] Patent: WO2015/116492, 2015, A1. Location in patent: Page/Page column 80
N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE Suppliers
- Tel
- tp@aladdinsci.com
- Country
- United States
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- 52923
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- 58
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- United States
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- sales@combi-blocks.com
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View Lastest Price from N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE manufacturers
- Product
- N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE 1026796-81-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-25