4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
- Product Name
- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
- CAS No.
- 24391-41-1
- Chemical Name
- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
- Synonyms
- 4-CHLRO-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBON;4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-5-carbonitrile;4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile;7H-Pyrrolo[2,3-d]pyriMidine-5-carbonitrile,4-chloro-
- CBNumber
- CB42470126
- Molecular Formula
- C7H3ClN4
- Formula Weight
- 178.58
- MOL File
- 24391-41-1.mol
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Property
- Boiling point:
- 235.3±50.0 °C(Predicted)
- Density
- 1+-.0.1 g/cm3(Predicted)
- storage temp.
- -20°C, sealed storage, away from moisture
- form
- solid
- pka
- 8.84±0.20(Predicted)
- color
- Light yellow
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C422120
- Product name
- 4-Chloro-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 059866
- Product name
- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
- Purity
- >96%
- Packaging
- 500mg
- Price
- $81
- Updated
- 2021/12/16
- Product number
- 059866
- Product name
- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
- Purity
- >96%
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 3H37-5-15
- Product name
- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FC144200
- Product name
- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Chemical Properties,Usage,Production
Synthesis
908287-23-0
24391-41-1
To a suspension of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde oxime (865 mg, 4.40 mmol, 1.0 eq.) in dichloromethane (20 mL) was slowly added thionyl chloride (3.1 mL, 43.7 mmol, 10.0 eq.). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The residue was suspended in water (60 mL) and the pH was adjusted slowly to 4 by addition of saturated aqueous sodium bicarbonate.The precipitated solid was collected by diafiltration and washed sequentially with water and ethyl acetate to give the first products. Subsequently, the filtrate was extracted with ethyl acetate (50 mL x 3). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the resulting residue was combined with the aforementioned solid. The crude product was recrystallized in a mixed solvent of ethyl acetate/hexane (1:1, v/v) and dried under reduced pressure to give 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (763 mg, 97% yield).ESI-MS m/z: 178.8 [M + H]+, 176.8 [M - H]+.
References
[1] Patent: WO2013/12915, 2013, A1. Location in patent: Paragraph 00942
[2] Patent: WO2008/12635, 2008, A2. Location in patent: Page/Page column 83
[3] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 25
[4] Patent: WO2011/146882, 2011, A1. Location in patent: Page/Page column 110-111
[5] Patent: US2012/122838, 2012, A1. Location in patent: Page/Page column 81-82
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile manufacturers
- Product
- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 24391-41-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08