ChemicalBook > CAS DataBase List > 7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one

7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one

Product Name
7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
CAS No.
1245643-21-3
Chemical Name
7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
Synonyms
7-bromo-4,4-dimethyl-1H-3,1-benzoxazin-2-one;7-Bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H);7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one;7-Bromo-1,4-dihydro-4,4-dimethyl-2H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one, 7-bromo-1,4-dihydro-4,4-dimethyl-
CBNumber
CB42470515
Molecular Formula
C10H10BrNO2
Formula Weight
256.1
MOL File
1245643-21-3.mol
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7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one Property

Boiling point:
258℃
Density 
1.468
Flash point:
110℃
storage temp. 
Sealed in dry,Room Temperature
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
300202
Product name
7-Bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
Packaging
250.00mg
Price
$91
Updated
2026/05/19
Matrix Scientific
Product number
300202
Product name
7-Bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
Packaging
1.00g
Price
$232
Updated
2026/05/19
Matrix Scientific
Product number
300202
Product name
7-Bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
Packaging
5.00g
Price
$750
Updated
2026/05/19
Synthonix
Product number
B32013
Product name
7-Bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
Purity
95+%
Packaging
50mg
Price
$64
Updated
2026/05/06
Synthonix
Product number
B32013
Product name
7-Bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
Purity
95+%
Packaging
100mg
Price
$130
Updated
2026/05/06
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7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one Chemical Properties,Usage,Production

Synthesis

1451389-06-2

530-62-1

1245643-21-3

Step 2: To a solution of 2-(2-amino-4-bromophenyl)propan-2-ol (2.3 g, 10.0 mmol) in tetrahydrofuran (THF, 50 mL) was added N,N'-carbonyl diimidazole (CDI, 1.95 g, 12.0 mmol) at room temperature. The reaction mixture was slowly warmed to 60 °C and the reaction was stirred at this temperature overnight. After completion of the reaction, the solvent was removed by rotary evaporator. The residue was dissolved in ethyl acetate (50 mL) and washed sequentially with 1M aqueous hydrochloric acid (20 mL x 2) and saturated saline (20 mL x 2). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. The resulting crude product was recrystallized by mixed solvent recrystallization of dichloromethane (DCM) and hexane to afford 7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one (2.3 g, 7.37% yield) as a white solid.

References

[1] Patent: WO2013/124026, 2013, A1. Location in patent: Page/Page column 173
[2] Patent: KR2016/37198, 2016, A. Location in patent: Paragraph 3363-3364; 3367

7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one Suppliers

Shanghai Boc Chemical Co.,Ltd
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021-34975603-808 18721111801
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+86-21-34975602-805
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sales@bocpharma.com
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China
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
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Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
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China
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1958
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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Shanghai Changyan Chem & Tech Co., Ltd.
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021-20242659 18930833303
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+86 (21) 2024-2659
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sales@changyanchem.cn
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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Taian Jiaye Biotechnology Co.Ltd
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Aikon International Limited
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025-66061636 19370895928
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(3)02557626880
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qqyang@aikonchem.com
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China
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Suzhou Nuoouman Biological Technology Co., Ltd.
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15026866316
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180642609@qq.com
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China
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Shanghai Jizhi Biochemical Technology Co. Ltd.
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1245643-21-3, 7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-oneRelated Search:


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  • 2H-3,1-Benzoxazin-2-one, 7-bromo-1,4-dihydro-4,4-dimethyl-
  • 7-bromo-4,4-dimethyl-1H-3,1-benzoxazin-2-one
  • 1245643-21-3
  • C10H10NO2Br