tert-Butyl (4-bromothiophen-2-yl)carbamate
- Product Name
- tert-Butyl (4-bromothiophen-2-yl)carbamate
- CAS No.
- 868387-45-5
- Chemical Name
- tert-Butyl (4-bromothiophen-2-yl)carbamate
- Synonyms
- 2-(Boc-aMino)-4-broMothiophene;tert-Butyl (4-bromothiophen-2-yl);tert-Butyl (4-broMo-2-thienyl)carbaMate;tert-Butyl (4-bromothiophen-2-yl)carbamate;tert-butyl N-(4-bromothiophen-2-yl)carbamate;2-(tert-Butoxycarbonylamino)-4-bromothiophene;(4-Bromo-2-thienyl)carbamic Acid tert-Butyl Ester;(4-Bromothiophen-2-yl)carbamic Acid tert-Butyl Ester;N-(4-BroMo-2-thienyl)-carbaMic Acid 1,1-DiMethylethyl Ester;Carbamic acid, N-(4-bromo-2-thienyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB42471471
- Molecular Formula
- C9H12BrNO2S
- Formula Weight
- 278.17
- MOL File
- 868387-45-5.mol
tert-Butyl (4-bromothiophen-2-yl)carbamate Property
- Boiling point:
- 279℃
- Density
- 1.510
- Flash point:
- 123℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 12.96±0.70(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C9H12BrNO2S/c1-9(2,3)13-8(12)11-7-4-6(10)5-14-7/h4-5H,1-3H3,(H,11,12)
- InChIKey
- QNGTVGAIEOIQBR-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC1SC=C(Br)C=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B6211
- Product name
- tert-Butyl (4-Bromothiophen-2-yl)carbamate
- Packaging
- 1G
- Price
- $155
- Updated
- 2025/07/31
- Product number
- B688120
- Product name
- N-(4-Bromo-2-thienyl)-carbamicAcid1,1-DimethylethylEster
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FB139397
- Product name
- tert-Butyl (4-bromothiophen-2-yl)carbamate
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- 45026
- Product name
- tert-Butyl(4-Bromothiophen-2-yl)carbamate,≥98%(HPLC)
- Purity
- ≥98%(HPLC)
- Packaging
- 5G
- Price
- $106.44
- Updated
- 2021/12/16
- Product number
- FB139397
- Product name
- tert-Butyl (4-bromothiophen-2-yl)carbamate
- Packaging
- 2g
- Price
- $112
- Updated
- 2021/12/16
tert-Butyl (4-bromothiophen-2-yl)carbamate Chemical Properties,Usage,Production
Uses
N-(4-bromo-2-thienyl)-carbamic Acid 1,1-Dimethylethyl Ester, is an intermediate for the synthesis of bicyclic inhibitors of ROCK protein kinsae.
Synthesis
16694-18-1
868387-45-5
4-Bromothiophene-2-carboxylic acid (3.0 g, 14.5 mmol) was used as starting material and dissolved in 36 mL of anhydrous tert-butanol. Subsequently, diphenylphosphoryl azide (DPPA, 4.06 mL, 18.8 mmol) and triethylamine (Et3N, 4.04 mL, 29.0 mmol) were added sequentially to the solution. The reaction mixture was stirred at 100 °C for 5 h. The reaction process was monitored by high performance liquid chromatography (HPLC). After completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by Combiflash silica gel column chromatography with the eluent being a hexane solution of 0-5% ethyl acetate, resulting in 3.10 g (77% yield) of tert-butyl (4-bromothiophen-2-yl)carbamate as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ= 7.04 (br.s, 1H), 6.73 (dd, J = 1.8 Hz, 0.4 Hz, 1H), 6.44 (d, J = 1.8 Hz, 1H), 1.52 (s, 9H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 19, p. 3210 - 3215
tert-Butyl (4-bromothiophen-2-yl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl (4-bromothiophen-2-yl)carbamate Suppliers
- Tel
- 021-50795510 4000665055
- syeu@accelachem.com
- Country
- China
- ProdList
- 11015
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 021-54880687
- Fax
- 021-54880687
- Country
- China
- ProdList
- 511
- Advantage
- 55
- Tel
- 025-58390181 58390186 18912901218
- Fax
- 025-58390182
- sales@fastchem.cn
- Country
- China
- ProdList
- 162
- Advantage
- 60
View Lastest Price from tert-Butyl (4-bromothiophen-2-yl)carbamate manufacturers
- Product
- tert-Butyl (4-bromothiophen-2-yl)carbamate 868387-45-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01