Ethyl 4-Cyclopropyl-1,3-thiazole-2-carboxylate
- Product Name
- Ethyl 4-Cyclopropyl-1,3-thiazole-2-carboxylate
- CAS No.
- 439692-05-4
- Chemical Name
- Ethyl 4-Cyclopropyl-1,3-thiazole-2-carboxylate
- Synonyms
- Ethyl 4-cyclopropyl-2-thiazolecarboxylate;Ethyl 4-cyclopropylthiazole-2-carboxylate;Ethyl 4-Cyclopropyl-1,3-thiazole-2-carboxylate;4-Cyclopropylthiazole-2-carboxylic acid ethyl ester;2-Thiazolecarboxylic acid, 4-cyclopropyl-, ethyl ester
- CBNumber
- CB42473930
- Molecular Formula
- C9H11NO2S
- Formula Weight
- 197.25
- MOL File
- 439692-05-4.mol
Ethyl 4-Cyclopropyl-1,3-thiazole-2-carboxylate Property
- Boiling point:
- 301.5±35.0 °C(Predicted)
- Density
- 1.276±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.75±0.10(Predicted)
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E926305
- Product name
- Ethyl4-cyclopropyl-1,3-thiazole-2-carboxylate
- Packaging
- 500mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- OR965854
- Product name
- Ethyl4-cyclopropyl-1,3-thiazole-2-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 114681
- Product name
- Ethyl 4-cyclopropyl-1,3-thiazole-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $354
- Updated
- 2021/12/16
- Product number
- CHM0299952
- Product name
- ETHYL-4-CYCLOPROPYL-1,3-THIAZOLE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.07
- Updated
- 2021/12/16
- Product number
- OR965854
- Product name
- Ethyl4-cyclopropyl-1,3-thiazole-2-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $965
- Updated
- 2021/12/16
Ethyl 4-Cyclopropyl-1,3-thiazole-2-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 4-cyclopropyl-1,3-thiazole-2-carboxylate
Synthesis
16982-21-1
69267-75-0
439692-05-4
General procedure for the synthesis of ethyl 4-cyclopropyl-2-thiazolecarboxylate from ethyl thiooxalate and 1-cyclopropyl-2-bromoacetophenone: 2-bromo-1-cyclopropylacetophenone (6.80 g, 42.0 mmol) and ethyl aminothioacetate (4.66 g, 35.0 mmol) were dissolved in ethanol (50 mL). The reaction mixture was heated to reflux for 1 hour. After completion of the reaction, the mixture was concentrated to dryness. The residue was purified by fast column chromatography (silica gel as stationary phase, eluent hexane/ethyl acetate = 4:1) to afford ethyl 4-cyclopropyl-2-thiazolecarboxylate (6.7 g, 98% yield). Mass spectrometry analysis: calculated value (C9H11NO2S + H)+: 198.06; measured value: (M+H)+ =198.05.
References
[1] Patent: US2010/196321, 2010, A1. Location in patent: Page/Page column 22
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7351 - 7356
Ethyl 4-Cyclopropyl-1,3-thiazole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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