(2,6-Dichloro-3-pyridinyl)methanol
- Product Name
- (2,6-Dichloro-3-pyridinyl)methanol
- CAS No.
- 55304-90-0
- Chemical Name
- (2,6-Dichloro-3-pyridinyl)methanol
- Synonyms
- (2,6-Dichloropyridin-3-yl);2,6-Dichloro-3-(hydroxyme...;2,6-Dichloropyridine-3-methanol;3-PyridineMethanol, 2,6-dichloro-;(2,6-Dichloro-3-pyridinyl)methanol;2,6-Dichloro-3-pyridinemethanol,95%;2,6-Dichloro-3-pyridineMethanol, 95%;2,6-Dichloro-3-(hydroxyMethyl)pyridine
- CBNumber
- CB42482901
- Molecular Formula
- C6H5Cl2NO
- Formula Weight
- 178.02
- MOL File
- 55304-90-0.mol
(2,6-Dichloro-3-pyridinyl)methanol Property
- Melting point:
- 67-69°
- Boiling point:
- 311.6±37.0 °C(Predicted)
- Density
- 1.478±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 12?+-.0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H5Cl2NO/c7-5-2-1-4(3-10)6(8)9-5/h1-2,10H,3H2
- InChIKey
- FWEVVZQDRPWAND-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC=C1CO
- CAS DataBase Reference
- 55304-90-0
Safety
- WGK Germany
- WGK 3
- HazardClass
- IRRITANT
- HS Code
- 2933399990
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- KOB0069
- Product name
- (2,6-Dichloro-3-pyridinyl)methanol
- Packaging
- 1G
- Price
- $308
- Updated
- 2023/06/20
- Product number
- B419248
- Product name
- (2,6-Dichloropyridin-3-yl)methanol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 047209
- Product name
- (2,6-Dichloro-3-pyridinyl)methanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 4H01-5-20
- Product name
- (2,6-Dichloropyridin-3-yl)methanol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Z0687
- Product name
- 2,6-Dichloro-3-(hydroxymethyl)pyridine
- Packaging
- 1g
- Price
- $91
- Updated
- 2021/12/16
(2,6-Dichloro-3-pyridinyl)methanol Chemical Properties,Usage,Production
Synthesis
38496-18-3
55304-90-0
The general procedure for the synthesis of 2,6-dichloro-3-hydroxymethylpyridine from 2,6-dichloronicotinic acid was as follows: 2,6-dichloronicotinic acid (1000 mg, 5.21 mmol) was dissolved in anhydrous tetrahydrofuran (5 mL) and the solution was cooled to 0 °C. Borane-tetrahydrofuran complex (7.82 mL, 7.82 mmol, 1.0 M tetrahydrofuran solution) was slowly added under stirring. The reaction mixture was stirred overnight at room temperature. Subsequently, water (1 mL) and potassium carbonate were added and stirring was continued for 2 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated to give the crude product. The crude product was purified by silica gel column chromatography with the eluent being a 10:90 to 20:80 ethyl acetate/hexane solvent mixture to give 2,6-dichloro-3-hydroxymethylpyridine (876 mg, 94% yield). The structure of the product was confirmed by 1H NMR (400 MHz, MeOH-d4): δ 7.96 (d, 1H, J = 8.0 Hz), 7.45 (d, 1H, J = 8.0 Hz), 4.64 (s, 2H).
References
[1] Patent: WO2006/44454, 2006, A1. Location in patent: Page/Page column 62
[2] Patent: WO2014/100695, 2014, A1. Location in patent: Paragraph 00408
[3] Patent: WO2006/85212, 2006, A2. Location in patent: Page/Page column 43
[4] Patent: US6573274, 2003, B1
(2,6-Dichloro-3-pyridinyl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (2,6-Dichloro-3-pyridinyl)methanol manufacturers
- Product
- 2,6-Dichloro-3-pyridinyl)methanol 55304-90-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-14