5-bromo-2-tert-butylpyridine
- Product Name
- 5-bromo-2-tert-butylpyridine
- CAS No.
- 39919-58-9
- Chemical Name
- 5-bromo-2-tert-butylpyridine
- Synonyms
- 5-Bromo-2-(tert-butyl);5-bromo-2-tert-butylpyridine;3-Bromo-6-(tert-butyl)pyridine;5-BroMo-2-(1,1-diMethylethyl)pyridine;Pyridine, 5-bromo-2-(1,1-dimethylethyl)-
- CBNumber
- CB42484389
- Molecular Formula
- C9H12BrN
- Formula Weight
- 214.1
- MOL File
- 39919-58-9.mol
5-bromo-2-tert-butylpyridine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to yellow Liquid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B258198
- Product name
- 5-bromo-2-tert-butylpyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B258198
- Product name
- 5-bromo-2-tert-butylpyridine
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B258198
- Product name
- 5-bromo-2-tert-butylpyridine
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- X6374
- Product name
- 3-Bromo-6-(tert-butyl)pyridine
- Packaging
- 250mg
- Price
- $276
- Updated
- 2021/12/16
- Product number
- X6374
- Product name
- 3-Bromo-6-(tert-butyl)pyridine
- Packaging
- 1g
- Price
- $591
- Updated
- 2021/12/16
5-bromo-2-tert-butylpyridine Chemical Properties,Usage,Production
Synthesis
223463-13-6
39919-58-9
Synthesis of 5-bromo-2-tert-butylpyridine: To a suspension of copper cyanide (1.79 g, 20 mmol) in THF (40 mL), which had been dried under reduced pressure for 4 h, a tert-butylmagnesium chloride solution (40 mL, 40 mmol) in 1.0 M THF was added dropwise slowly over a period of 30 min at -78 °C. The reaction mixture was then stirred for 1 h. After the reaction was completed, the reaction was continued with stirring for 1 h. The reaction mixture was then stirred for 1 h at -78 °C. After the dropwise addition, the reaction mixture was continued to be stirred at -78 °C for 1 hour. Subsequently, 5-bromo-2-iodopyridine (2.83 g, 10 mmol) was added at the same temperature and stirred at -78 °C for 1 h. After that, the reaction mixture was warmed up to room temperature and stirred for 16 h. The reaction was completed with the addition of 25% M THF. Upon completion of the reaction, the reaction was quenched with 25% ammonia solution (40 mL), the resulting precipitate was removed by filtration and the precipitate was washed with EtOAc. The filtrate and washings were combined and concentrated under vacuum. The concentrated product was purified by silica gel column chromatography using hexane/EtOAc (20:1) as eluent to afford the target compound 5-bromo-2-tert-butylpyridine (1.07 g, 50% yield) as a colorless oil.1H NMR (300 MHz, CDCl3) δ 1.35 (9H, s), 7.24 (1H, d, J = 8.1 Hz), 7.72 (1H, d, J = 8.1 Hz) 7.72 (1H, dd, J = 2.2, 8.1 Hz), 8.61-8.62 (1H, m).
References
[1] Patent: US2006/211741, 2006, A1. Location in patent: Page/Page column 61
5-bromo-2-tert-butylpyridine Preparation Products And Raw materials
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