(R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one

Product Name: (R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one
CAS No.: 877676-50-1
Chemical Name: (R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one
Synonyms: 2-Chloro-7-ethyl-8-isopropyl-5-Methyl-7,8-dihydro-5H-pteridin-6-one;(R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one;(R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one;(7R)-2-Chloro-7-ethyl-7,8-dihydro-5-methyl-8-(1-methylethyl)-6(5H)-pteridinone;(7R)-2-chloro-7-ethyl-5-methyl-8-(propan-2-yl)-5,6,7,8-tetrahydropteridin-6-one;6(5H)-Pteridinone, 2-chloro-7-ethyl-7,8-dihydro-5-Methyl-8-(1-Methylethyl)-, (7R)-;(R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropyrimido[4,5-b]pyrazine
CBNumber: CB42485119
Molecular Formula: C12H17ClN4O
Formula Weight: 268.74
MOL File: 877676-50-1.mol

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(R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one Property

Boiling point:: 492.1±40.0 °C(Predicted)
Density: 1.205
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.48±0.40(Predicted)
Appearance: white solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C366113
Product name: (R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one
Packaging: 1g
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 0407DP
Product name: (R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one
Packaging: 5g
Price: $267
Updated: 2021/12/16

ACHEMBLOCK

Product number: P44194
Product name: (7R)-2-chloro-7-ethyl-5-methyl-8-(propan-2-yl)-5,6,7,8-tetrahydropteridin-6-one
Purity: 97%
Packaging: 250MG
Price: $100
Updated: 2021/12/16

ACHEMBLOCK

Product number: P44194
Product name: (7R)-2-chloro-7-ethyl-5-methyl-8-(propan-2-yl)-5,6,7,8-tetrahydropteridin-6-one
Purity: 97%
Packaging: 1G
Price: $245
Updated: 2021/12/16

Chemcia Scientific

Product number: CC00-6002
Product name: (R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one
Purity: ＞95%
Packaging: 1g
Price: $395
Updated: 2021/12/16

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(R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one Chemical Properties,Usage,Production

Uses

(R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one is a compound that has been involved in the preparation of selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain.

Synthesis

889877-77-4

616-38-6

877676-50-1

A reaction was carried out in 30 mL of potassium carbonate suspension with (R)-2-chloro-7-ethyl-8-isopropyl-7,8-dihydropteridin-6(5H)-one (27.5 mmol, 7 g) and dimethyl carbonate (41 mmol, 5.7 g). The reaction mixture was placed in an autoclave, heated to 130 °C and maintained for 5 hours. Upon completion of the reaction, the mixture was cooled to 25°C. Subsequently, 25 mL of deionized water and 15 mL of ethyl acetate were added and mixed with stirring. The organic phase was concentrated by distillation under reduced pressure. To the residue, 25 mL of ethanol and 45 mL of deionized water were added and heated to 60°C to dissolve. The solution was cooled to room temperature and the precipitate was collected by filtration. The precipitate was washed with a mixture of softened water and ethanol (2:1 volume ratio). Finally, the product was dried in a vacuum drying oven at 50 °C to afford (R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one (6 g, 82% yield).

References

[1] Patent: WO2007/90844, 2007, A1. Location in patent: Page/Page column 14
[2] Patent: WO2009/19205, 2009, A1. Location in patent: Page/Page column 14

(R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one manufacturers

Career Henan Chemical Co

Product: (R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one 877676-50-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-13

877676-50-1, (R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-oneRelated Search:

(R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one

(7R)-2-Chloro-7-ethyl-7,8-dihydro-5-methyl-8-(1-methylethyl)-6(5H)-pteridinone

2-Chloro-7-ethyl-8-isopropyl-5-Methyl-7,8-dihydro-5H-pteridin-6-one

6(5H)-Pteridinone, 2-chloro-7-ethyl-7,8-dihydro-5-Methyl-8-(1-Methylethyl)-, (7R)-

(R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropyrimido[4,5-b]pyrazine

(R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one

(7R)-2-chloro-7-ethyl-5-methyl-8-(propan-2-yl)-5,6,7,8-tetrahydropteridin-6-one

877676-50-1