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tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

Product Name
tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
CAS No.
135716-08-4
Chemical Name
tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
Synonyms
(1-Boc-piperid;Ethyl 2-(1-Boc-4-piperidylidene)acetate;tert-Butyl 4-(2-ethoxy-2-oxoethylidene);Ethyl (1-Boc-piperidin-4-ylidene)acetate;_x000D_Ethyl 2-(1-Boc-4-piperidylidene)acetate;Ethyl [1-(tert-Butoxycarbonyl)piperidin-4-ylidene]acetate;1-piperidinecarboxylic acid, 4-(2-ethoxy-2-oxoethylidene)-;4-(Ethoxycarbonylmethylene)-1-(tert-butoxycarbonyl)piperidine;tert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidin-1-carboxylate;ert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
CBNumber
CB42485230
Molecular Formula
C14H23NO4
Formula Weight
269.34
MOL File
135716-08-4.mol
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tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate Property

Melting point:
85 °C
Boiling point:
354℃
Density 
1.129
Flash point:
168℃
storage temp. 
2-8°C
form 
powder to crystal
pka
-1.46±0.20(Predicted)
color 
White to Almost white
InChI
InChI=1S/C14H23NO4/c1-5-18-12(16)10-11-6-8-15(9-7-11)13(17)19-14(2,3)4/h10H,5-9H2,1-4H3
InChIKey
NJORMFNJZLXLCN-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC/C(=C\C(OCC)=O)/CC1
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5855
Product name
tert-Butyl 4-(2-Ethoxy-2-oxoethylidene)piperidine-1-carboxylate
Purity
>97.0%(GC)
Packaging
1g
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
B5855
Product name
tert-Butyl 4-(2-Ethoxy-2-oxoethylidene)piperidine-1-carboxylate
Purity
>97.0%(GC)
Packaging
5g
Price
$177
Updated
2025/07/31
TRC
Product number
B694630
Product name
tert-Butyl 4-(2-Ethoxy-2-oxoethylidene)piperidine-1-carboxylate
Packaging
500mg
Price
$110
Updated
2021/12/16
TRC
Product number
B694630
Product name
tert-Butyl 4-(2-Ethoxy-2-oxoethylidene)piperidine-1-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB123228
Product name
tert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
Packaging
500mg
Price
$100
Updated
2021/12/16
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tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

867-13-0

79099-07-3

135716-08-4

The general procedure for the synthesis of tert-butyl 4-(2-ethoxy-2-oxo-substituted)piperidine-1-carboxylate from triethyl phosphonoacetate and N-tert-butoxycarbonyl-4-piperidone was as follows: to a solution of tetrahydrofuran (200 mL) of ethyl diethylphosphonoacetate (28.3 g) was added 60% sodium hydride (4.82 g). The mixture was stirred under cooling in an ice bath for 30 min, followed by the slow dropwise addition of a tetrahydrofuran (200 mL) solution of N-tert-butoxycarbonyl-4-piperidone (20 g). The reaction mixture was stirred continuously for 22 h at room temperature. Upon completion of the reaction, the reaction was terminated by the addition of water (200 mL) and extracted with ethyl acetate. The organic phases were combined and washed with saturated aqueous sodium chloride solution and subsequently dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the crude product was purified by silica gel column chromatography using hexane/ethyl acetate (6:1) as eluent to finally obtain tert-butyl 4-(2-ethoxy-2-oxo-substituted)piperidine-1-carboxylate (27.3 g, 100% yield) as a colorless powder. The product was characterized by 1H NMR (CDCl3): δ 1.28 (3H, t, J = 7.4 Hz), 1.47 (9H, s), 2.24-2.33 (2H, m), 2.90-2.98 (2H, m), 3.43-3.55 (4H, m), 4.16 (2H, q, J = 7.4 Hz), 5.70-5.73 (1H, m ).

References

[1] Heterocycles, 2001, vol. 54, # 2, p. 747 - 755
[2] Patent: EP1498125, 2005, A1. Location in patent: Page/Page column 84-85
[3] Patent: WO2018/152329, 2018, A1. Location in patent: Page/Page column 48
[4] Patent: CN102952072, 2016, B. Location in patent: Paragraph 0109
[5] Chinese Chemical Letters, 2012, vol. 23, # 6, p. 707 - 710

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate Suppliers

Americas 1 China 110 Europe 1 France 1 Germany 1 India 3 Italy 1 Japan 1 United Kingdom 3 United States 10 Global 132
Suzhou Xinrui Biotechnology Co., Ltd.
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13401437572
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China
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Shanghai Hobor Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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NovoChemy Ltd.
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View Lastest Price from tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate manufacturers

Anhui Dexinjia Biopharm Co., Ltd
Product
Tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 135716-08-4
Price
US $100.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2025-05-06
Shaanxi Dideu New Materials Co. Ltd
Product
tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 135716-08-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-01
Career Henan Chemical Co
Product
tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 135716-08-4
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

135716-08-4, tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylateRelated Search:

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