2-(bromomethyl)-6-(trifluoromethyl)pyridine
- Product Name
- 2-(bromomethyl)-6-(trifluoromethyl)pyridine
- CAS No.
- 781637-62-5
- Chemical Name
- 2-(bromomethyl)-6-(trifluoromethyl)pyridine
- Synonyms
- 2-(bromomethyl)-6-(trifluoromethyl)pyridine;Pyridine, 2-(bromomethyl)-6-(trifluoromethyl)-
- CBNumber
- CB42485285
- Molecular Formula
- C7H5BrF3N
- Formula Weight
- 240.02
- MOL File
- 781637-62-5.mol
2-(bromomethyl)-6-(trifluoromethyl)pyridine Property
- Boiling point:
- 190.1±35.0 °C(Predicted)
- Density
- 1.647±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -1.24±0.24(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB143623
- Product name
- 2-(Bromomethyl)-6-(trifluoromethyl)pyridine
- Packaging
- 100mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- FB143623
- Product name
- 2-(Bromomethyl)-6-(trifluoromethyl)pyridine
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- FB143623
- Product name
- 2-(Bromomethyl)-6-(trifluoromethyl)pyridine
- Packaging
- 500mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- FB143623
- Product name
- 2-(Bromomethyl)-6-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $410
- Updated
- 2021/12/16
- Product number
- HCH0103554
- Product name
- 2-(BROMOMETHYL)-6-(TRIFLUOROMETHYL)PYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.01
- Updated
- 2021/12/16
2-(bromomethyl)-6-(trifluoromethyl)pyridine Chemical Properties,Usage,Production
Synthesis
1620-72-0
781637-62-5
General procedure for the synthesis of 2-(bromomethyl)-6-(trifluoromethyl)pyridine using 2-methyl-6-(trifluoromethyl)pyridine as starting material: 2-methyl-6-(trifluoromethyl)pyridine (100 mg, 0.620 mmol) was dissolved in carbon tetrachloride (CCl4, 3 mL), and N-bromosuccinimide (NBS, 110 mg, 0.620 mmol) and 1,1'-azobis(cyclohexanenitrile) (VAZO, 8 mg, 0.031 mmol). The reaction mixture was heated and stirred at 90 °C for 15 hours. After completion of the reaction, the reaction solution was filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by medium pressure liquid chromatography (MPLC, hexane/ethyl acetate = 5:1) to afford 2-(bromomethyl)-6-(trifluoromethyl)pyridine as a white solid (42.5 mg, 28.4% yield).1H NMR (300 MHz, CDCl3) δ 4.60 (2H, s), 7.61 (1H, d), 7.68 (1H, d) , 7.90 (1H, t).
References
[1] Patent: WO2013/129879, 2013, A1. Location in patent: Page/Page column 50; 51
[2] Patent: US2015/166558, 2015, A1. Location in patent: Paragraph 0300; 0301; 0302
2-(bromomethyl)-6-(trifluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-(bromomethyl)-6-(trifluoromethyl)pyridine Suppliers
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