1-Boc-7-Azaindole-3-boronic acid pinacol ester
- Product Name
- 1-Boc-7-Azaindole-3-boronic acid pinacol ester
- CAS No.
- 942070-47-5
- Chemical Name
- 1-Boc-7-Azaindole-3-boronic acid pinacol ester
- Synonyms
- 1-Boc-7-Azaindole-3-boron...;1-Boc-7-Azaindole-3-boronic acid pinacol ester;tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrol...;N-Boc-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole;(1-(TERT-BUTOXYCARBONYL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate;tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxy;tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine-1-carboxylate;tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylat;tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
- CBNumber
- CB42485432
- Molecular Formula
- C18H25BN2O4
- Formula Weight
- 344.21
- MOL File
- 942070-47-5.mol
1-Boc-7-Azaindole-3-boronic acid pinacol ester Property
- Melting point:
- 115-117 °C
- Boiling point:
- 460.9±48.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 2.68±0.30(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B601828
- Product name
- 1-BOC-7-Azaindole-3-boronicacid,pinacolester
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 8H60-1-8P
- Product name
- 1-Boc-7-azaindole-3-boronic acid, pinacol ester
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 068576
- Product name
- tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
- Purity
- 96%
- Packaging
- 1g
- Price
- $410
- Updated
- 2021/12/16
- Product number
- P0211
- Product name
- tert-Butyl3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 5g
- Price
- $420
- Updated
- 2021/12/16
- Product number
- BOR0011683
- Product name
- 1-BOC-7-AZAINDOLE-3-BORONIC ACID PINACOL ESTER
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $951.72
- Updated
- 2021/12/16
1-Boc-7-Azaindole-3-boronic acid pinacol ester Chemical Properties,Usage,Production
Synthesis
73183-34-3
192189-18-7
942070-47-5
1-Boc-3-iodo-7-azaindole (7.5 g, 0.022 mol) was used as a starting material and reacted with bis(pinacolato)diboron (16.6 g, 0.065 mol), potassium acetate (12.8 g, 0.13 mol), and [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichloromethane complex (1.78 g, 0.002 mol) was mixed in 80 mL of N,N-dimethylformamide and reacted at 90 °C for 3 hours. After completion of the reaction, the solvent was removed by rotary evaporation and the residue was dissolved in dichloromethane and purified by ISCO column chromatography with the eluent being a hexane solution of 15-25% ethyl acetate to give the target product (10% yield). Mass spectrum (ES+) m/z = 345 (M + 1). Also taken were tert-butyl 3-iodo-pyrrolo[2,3-b]pyridine-1-carboxylate (490 mg, 0.00142 mol), bis(pinacolato)diboron (1.11 g, 0.00436 mol), potassium acetate (0.86 g, 0.0087 mol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride dichloromethane complex ( 0.117 g, 0.000143 mol) was dissolved in N,N-dimethylformamide (8 mL) in a sealed tube and reacted at 80 °C for 2.5 hours. After the reaction, the solvent was removed by evaporation and purified by silica gel column chromatography to afford tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (234 mg, 48% yield). Mass spectrum m/z = 345.24 (M + 1).1H NMR (300 MHz, CDCl3) δ 8.478 (dd, J = 4.6, 1.5 Hz, 1H), 8.234 (dd, J = 7.7, 1.7 Hz, 1H), 8.031 (s, 1H), 7.191 (dd, J = 7.9, 4.8 Hz, 1H), 1.644 (s, 9H), 1.352 (s, 12H).TLC Rf = 0.43 (Expander: 3:1 hexane/ethyl acetate).
References
[1] Patent: WO2008/5457, 2008, A2. Location in patent: Page/Page column 101; 109
1-Boc-7-Azaindole-3-boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
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View Lastest Price from 1-Boc-7-Azaindole-3-boronic acid pinacol ester manufacturers
- Product
- 1-Boc-7-Azaindole-3-boronic acid pinacol ester 942070-47-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-14