4-(2-Bromoethyl)benzonitrile
- Product Name
- 4-(2-Bromoethyl)benzonitrile
- CAS No.
- 72054-56-9
- Chemical Name
- 4-(2-Bromoethyl)benzonitrile
- Synonyms
- 4-Cyanophenethyl bromide;p-Cyanophenethyl bromide;p-(2-Bromoethyl)benzonitrile;4-(2-Bromoethyl)benzonitrile;Benzonitrile, 4-(2-bromoethyl)-
- CBNumber
- CB42489586
- Molecular Formula
- C9H8BrN
- Formula Weight
- 210.07
- MOL File
- 72054-56-9.mol
4-(2-Bromoethyl)benzonitrile Property
- Melting point:
- 53-54℃
- Boiling point:
- 290℃
- Density
- 1.43
- Flash point:
- 129℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B997628
- Product name
- 4-(2-Bromoethyl)benzonitrile
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B997628
- Product name
- 4-(2-Bromoethyl)benzonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB144160
- Product name
- 4-(2-Bromoethyl)benzonitrile
- Packaging
- 250mg
- Price
- $67.5
- Updated
- 2021/12/16
- Product number
- FB144160
- Product name
- 4-(2-Bromoethyl)benzonitrile
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- Z5069
- Product name
- 4-(2-Bromoethyl)benzonitrile
- Packaging
- 250mg
- Price
- $132
- Updated
- 2021/12/16
4-(2-Bromoethyl)benzonitrile Chemical Properties,Usage,Production
Synthesis
69395-13-7
72054-56-9
General procedure for the synthesis of 4-(2-bromoethyl)benzonitrile from 4-(2-hydroxyethyl)benzonitrile: to a stirred solution of 4-(2-hydroxyethyl)benzonitrile (1.0 g, 6.8 mmol, 1.0 eq.) in dichloromethane (DCM, 20 mL) was added sequentially carbon tetrabromide (CBr4, 4.5016 g, 13.6 mmol, 2.0 eq.) and triphenylphosphine (TPP, 3.835 g, 13.6 mmol, 2.0 equiv). The reaction mixture was stirred at room temperature for 5 hours and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated. The crude product was purified by column chromatography to afford pure 4-(2-bromoethyl)benzonitrile (1.3 g, 91% yield). The results of liquid chromatography-mass spectrometry (LC-MS, Method 23): retention time (Rt) = 2.01 min; mass-to-charge ratio (m/z) = 210.05 ([M+H]+).
References
[1] Patent: WO2018/149986, 2018, A1. Location in patent: Page/Page column 95
[2] Pharmazie, 1982, vol. 37, # 1, p. 13 - 16
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 1, p. 65 - 68
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1979, p. 1128 - 1132
[5] Patent: US5811459, 1998, A
4-(2-Bromoethyl)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(2-Bromoethyl)benzonitrile manufacturers
- Product
- 4-(2-Bromoethyl)benzonitrile 72054-56-9
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-03