(1r,4r)-methyl 4-formylcyclohexanecarboxylate
- Product Name
- (1r,4r)-methyl 4-formylcyclohexanecarboxylate
- CAS No.
- 54274-80-5
- Chemical Name
- (1r,4r)-methyl 4-formylcyclohexanecarboxylate
- Synonyms
- Methyl 4-forMylcyclohexanecarboxylate;(E)-Methyl 4-forMylcyclohexanecarboxylate;trans-Methyl 4-forMylcyclohexanecarboxylate;Methyl trans-4-forMylcyclohexanecarboxylate;(1r,4r)-methyl 4-formylcyclohexanecarboxylate;Methyl trans-4-formylcyclohexane-1-carboxylate;methyl(1r,4r)-4-formylcyclohexane-1-carboxylate;methyl Rel-(1r,4r)-4-formylcyclohexane-1-carboxylate;Itemname-(1R,4R)-Methyl4-formylcyclohexanecarboxylate;trans-4-formyl-cyclohexanecarboxylic acid methyl ester
- CBNumber
- CB42489834
- Molecular Formula
- C9H14O3
- Formula Weight
- 170.21
- MOL File
- 54274-80-5.mol
(1r,4r)-methyl 4-formylcyclohexanecarboxylate Property
- Boiling point:
- 236.4±33.0 °C(Predicted)
- Density
- 1.129±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- liquid
- color
- Colourless to light yellow
Safety
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Z4857
- Product name
- (1R,4R)-Methyl4-formylcyclohexanecarboxylate
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Z4857
- Product name
- (1R,4R)-Methyl4-formylcyclohexanecarboxylate
- Packaging
- 5g
- Price
- $196
- Updated
- 2021/12/16
- Product number
- Z4857
- Product name
- (1R,4R)-Methyl4-formylcyclohexanecarboxylate
- Packaging
- 10g
- Price
- $286
- Updated
- 2021/12/16
- Product number
- 35363
- Product name
- trans-Methyl4-formylcyclohexanecarboxylate
- Purity
- 95+%
- Packaging
- 1000mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- Z4857
- Product name
- (1R,4R)-Methyl4-formylcyclohexanecarboxylate
- Packaging
- 25g
- Price
- $590
- Updated
- 2021/12/16
(1r,4r)-methyl 4-formylcyclohexanecarboxylate Chemical Properties,Usage,Production
Synthesis
110928-44-4
54274-80-5
The general procedure for the synthesis of trans-methyl-4-(hydroxymethyl)cyclohexanecarboxylic acid from methyl trans-4-(hydroxymethyl)cyclohexanecarboxylate was as follows: oxalyl chloride (7.74 g, 61.0 mmol) was slowly added to an anhydrous dichloromethane (400 mL) solution of dimethyl sulfoxide (9.53 g, 122 mmol) at -78 °C. After removing the cooling bath, the reaction mixture was stirred at -50 °C for 5 min. Subsequently, a solution of methyl trans-4-hydroxymethyl-cyclohexanecarboxylate (8.75 g, 50.8 mmol) in dichloromethane (108 mL) was added at -65 °C. After continued stirring for 30 minutes, triethylamine (25.7 g, 254 mmol) was added. Fifteen minutes after the addition was complete, the cooling bath was removed. The reaction mixture was quenched with 1 M aqueous hydrochloric acid (152 mL, 152 mmol) at -10 °C. The organic and aqueous layers were separated, and the organic layer was washed sequentially with two parts of 250 mL of water and one part of 100 mL of brine, and then dried with anhydrous sodium sulfate. Finally, a yellow oily trans-methyl-4-formylcyclohexanecarboxylic acid (9.3 g, quantitative yield) was obtained by vacuum concentration, which could be used directly in the next reaction without further purification.MS m/e: 170 (M+).
References
[1] Patent: US2014/221350, 2014, A1. Location in patent: Paragraph 0168
[2] Patent: EP1772454, 2007, A1. Location in patent: Page/Page column 55-56
[3] Patent: WO2013/192088, 2013, A1. Location in patent: Paragraph 00216
[4] ChemMedChem, 2016, vol. 11, # 1, p. 31 - 37
(1r,4r)-methyl 4-formylcyclohexanecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (1r,4r)-methyl 4-formylcyclohexanecarboxylate manufacturers
- Product
- Methyl4-formylcyclohexanecarboxylate 54274-80-5
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-24
- Product
- methyl trans-4-formylcyclohexanecarboxylate 54274-80-5
- Price
- US $0.00/gm
- Min. Order
- 10gm
- Purity
- 96%min
- Supply Ability
- 10kg
- Release date
- 2024-09-10
- Product
- trans-4-formyl-cyclohexanecarboxylic acid methyl ester 54274-80-5
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG/MONTH
- Release date
- 2020-11-04